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| Other names | RU-27592; HR-592 |
| Drug class | Atypical antipsychotic;Major tranquilizer |
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| Formula | C16H19ClN2 |
| Molar mass | 274.79 g·mol−1 |
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Tepirindole (INNTooltip International Nonproprietary Name; developmental code namesRU-27592,HR-592) is atryptamine-relatedatypical antipsychotic andmajor tranquilizer which was never marketed.[1][2][3][4][5] It is similar instructure to tryptamines but is not technically a tryptamine itself and is instead apiperidinylindole.[1][6] The drug is said to act ondopamineD2,serotonin5-HT2, andα1-adrenergic receptors.[3][4] It is apotentdopamine receptor antagonist but reportedly has little propensity to causecatalepsy and has been said to potentially be useful in treating thenegative symptoms ofschizophrenia.[4][5] The drug may also act as a potentserotonin receptor agonist.[6] Tepirindole was first described in the literature by 1979.[1][6]
Several potent blockers of DA receptors are also putative atypical antipsychotics. Tepirindole (HR-592, 25) has a high affinity for DA, 5-HT and NE receptors but has little propensity to cause catalepsy (78).
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