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| Formula | C15H23NS |
| Molar mass | 249.42 g·mol−1 |
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Tenocyclidine (TCP) is adissociativeanesthetic withpsychostimulant effects. It was discovered by a team atParke-Davis in the late 1950s.[2] It is similar in effects tophencyclidine (PCP) but is considerably more potent. TCP has slightly different binding properties to PCP, with more affinity for theNMDA receptors,[3] but less affinity for thesigma receptors.[4] Because of its high affinity for the PCP site of the NMDA receptor complex, the3Hradiolabelled form of TCP is widely used in research into NMDA receptors.
TCP acts primarily as anNMDA receptor antagonist which blocks the activity of the NMDA receptor, however its increased psychostimulant effects compared to PCP suggests it also has relatively greater activity as adopamine reuptake inhibitor (DRI). Due to its similarity in effects to PCP, TCP was placed into theSchedule I list of illegal drugs in the 1970s, although it was only briefly used in the 1970s and 1980s and is now little known.[citation needed]
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