Template talk:Tryptophan metabolism by human microbiota
Page contents not supported in other languages.
| This is thetalk page for discussing improvements to theTryptophan metabolism by human microbiota template. |
|
 | This template does not require a rating on Wikipedia'scontent assessment scale. It is of interest to the followingWikiProjects: | |||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||
@Slashme: Thanks for creating an svg version of the diagram. I noticed there's some weird text rendering in some places, specifically the underlined letters in the following words in the diagram:Tryptophan (top), antioxidant (bottom left),fibril (bottom left), calcification (right). Can you reupload the diagram with a different text font or just tweak the text spacing in those places?Seppi333 (Insert 2¢)21:32, 1 November 2017 (UTC)[reply]
Based upon past experience, copying the entire contents of an svg file into a new file in inkscape and re-saving it over the old file sometimes does the trick. The alternative in this particular case would be to take advantage of the fact that this diagram is displayed inan annotated image template by overlaying most of the horizontally-oriented text in the image onto the diagram as wikitext. An example of what this looks like is shown in the collapse tab below (note: I greatly increased the default font size for illustrative purposes);
.jpg)
{{Psychostimulant addiction}} is a good example of a wikitext-annotated svg image that's currently used in various articles.Seppi333 (Insert 2¢)22:06, 1 November 2017 (UTC)[reply]Your waffles are extremely tasty! See how niceaf:Triptofaan looks now. --Slashme (talk)21:55, 2 November 2017 (UTC)[reply]
Tryptophan metabolism byhuman gastrointestinal microbiota()  Waffles are tasty This diagram shows the biosynthesis ofbioactive compounds (indole and certain derivatives) fromtryptophan by bacteria in the gut.[1] Indole is produced from tryptophan by bacteria that expresstryptophanase.[1]Clostridium sporogenes metabolizes indole into3-indolepropionic acid (IPA),[2] a highly potentneuroprotectiveantioxidant that scavengeshydroxyl radicals.[1][3][4] In the intestine, IPA binds topregnane X receptors (PXR) in intestinal cells, thereby facilitating mucosal homeostasis andbarrier function.[1] Followingabsorption from the intestine anddistribution to the brain, IPA confers a neuroprotective effect againstcerebral ischemia andAlzheimer’s disease.[1]Lactobacillus species metabolize tryptophan intoindole-3-aldehyde (I3A) which acts on thearyl hydrocarbon receptor (AhR) in intestinal immune cells, in turn increasinginterleukin-22 (IL-22) production.[1] Indole itself acts as aglucagon-like peptide-1 (GLP-1)secretagogue inintestinal L cells and as a ligand for AhR.[1] Indole can also be metabolized by the liver intoindoxyl sulfate, a compound that is toxic in high concentrations and associated with vascular disease and renal dysfunction.[1] AST-120 (activated charcoal), an intestinalsorbent that istaken by mouth,adsorbs indole, in turn decreasing the concentration of indoxyl sulfate in blood plasma.[1] |
reflist |
|---|
|
Would this be better named as ..metabolism bygut flora which is more specific?--Iztwoz (talk)07:31, 8 January 2018 (UTC)[reply]
{{Tryptophan metabolism by human microbiota}} could always be used to call this template instead of the longer template name since it would become a template redirect if this page is moved to{{Tryptophan metabolism by human gastrointestinal microbiota}}. So, if you want to rename/move the template to the longer title, I'd be okay with that.Seppi333 (Insert 2¢)00:07, 9 January 2018 (UTC)[reply]