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| Names | |
|---|---|
| Preferred IUPAC name O-[4-({4-[(Dimethoxyphosphorothioyl)oxy]phenyl}sulfanyl)phenyl]O,O-dimethyl phosphorothioate | |
| Other names [4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]- dimethoxy-sulfanylidene-phosphorane | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.020.175 |
| KEGG |
|
| MeSH | Temefos |
| UNII | |
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| |
| Properties | |
| C16H20O6P2S3 | |
| Molar mass | 466.46 g·mol−1 |
| Appearance | white, crystalline solid[1] |
| Density | 1.32 g cm−3 |
| Melting point | 30 °C (86 °F; 303 K) |
| Boiling point | 120–125[1] °C (248–257 °F; 393–398 K) (decomposes) |
| insoluble[1] | |
| Vapor pressure | 0.00000007 mmHg (20°C)[1] |
| Hazards | |
| NIOSH (US health exposure limits): | |
PEL (Permissible) | 15 mg/m3[1] |
REL (Recommended) | TWA 10 mg/m3 (total) TWA 5 mg/m3 (resp)[1] |
IDLH (Immediate danger) | N.D.[1] |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Temefos ortemephos (trade nameAbate) is anorganophosphatelarvicide used to treat water infested with disease-carryinginsects[2] (includingmosquitoes,midges, andblack flylarvae) andcrustaceans (copepods).
As with other organophosphates, temephos affects thecentral nervous system through inhibition ofcholinesterase. In larvae, this results in death before reaching the adult stage.
In thedeveloping world where thevector-borne diseasedengue fever isendemic, temephos is widely used and applied by both private and public pest control in areas ofstanding water where theAedes aegypti mosquito breeds, in order to reduce the population of this disease-carrying insect.[3] Temephos is also used in theGuinea Worm Eradication Program to kill the copepods that carryguinea worm larvae.[4]
Resistance to temephos byA. aegypti has been seen inBrazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance inA. aegypti populations from several localities in the country in 1999 (Funasa 2000, Lima et al. 2003). In 1999, mosquitoes from the city ofRio de Janeiro were observed to be resistant to temephos.[5]
