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Tasosartan

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Chemical compound

Pharmaceutical compound

Tasosartan
Clinical data

Pregnancy category	N/A
ATC code	C09CA05 (WHO)
Legal status
Legal status	Withdrawn
Identifiers
IUPAC name 2,4-dimethyl-8-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
CAS Number	145733-36-4^Y
PubChemCID	60919
IUPHAR/BPS	6898
DrugBank	DB01349^Y
ChemSpider	54890^N
UNII	48G92V856H
CompTox Dashboard(EPA)	DTXSID40163148
Chemical and physical data
Formula	C₂₃H₂₁N₇O
Molar mass	411.469 g·mol⁻¹
^NY (what is this?) (verify)

Tasosartan is anangiotensin II receptor antagonist.

It was withdrawn from FDA review by the manufacturer afterphase III clinical trials showedelevated transaminases (a sign of possibleliver toxicity) in a significant number of participants given the drug.^[1]^[2]

v t e Antihypertensive drugs acting on therenin–angiotensin system (C09)
ACE inhibitors ("-pril")	Sulfhydryl-containing:Captopril Rentiapril Zofenopril (+nebivolol) Dicarboxylate-containing:Enalapril^# (+lercanidipine,+nitrendipine) Benazepril (+amlodipine,+pimobendan) Cilazapril Delapril (+manidipine) Imidapril Lisinopril (+amlodipine,+HCT) Moexipril Perindopril (+amlodipine,+bisoprolol,+indapamide,+amlodipine and indapamide,+bisoprolol and amlodipine,+bisoprolol, amlodipine, and indapamide) Quinapril (+HCT) Ramipril (+amlodipine,+amlodipine and HCT,+bisoprolol,+felodipine) Spirapril Temocapril Trandolapril (+verapamil) Phosphonate-containing:Ceronapril Fosinopril (+HCT) Other/ungrouped:Alacepril
AIIRAs ("-sartan")	Azilsartan Candesartan (+amlodipine,+amlodipine and HCT) Eprosartan Fimasartan Irbesartan (+amlodipine,+amlodipine and HCT,+HCT) Losartan (+amlodipine,+HCT) Olmesartan (+amlodipine,+amlodipine and HCT,+HCT) Tasosartan^§ Telmisartan (+amlodipine,+amlodipine and HCT,+amlodipine and indapamide,+HCT) Valsartan (+aliskiren,+amlodipine,+amlodipine and HCT,+HCT,+lercanidipine,+nebivolol,+sacubitril)
Renin inhibitors ("-kiren")	Aliskiren (+amlodipine,+HCT,+amlodipine and HCT) Remikiren^§
DualACE/NEP inhibitors	Gemopatrilat Ilepatril Omapatrilat Sampatrilat
Neprilysin inhibitors	Sacubitril (+valsartan)
Other	Sparsentan
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

v t e Angiotensin receptor modulators
ATRTooltip Angiotensin receptor	Agonists:Angiotensin II Angiotensin III Angiotensin IV L-163,491 Saralasin Antagonists:Abitesartan Azilsartan Candesartan Elisartan Embusartan Eprosartan EXP-3174 Fimasartan Forasartan Irbesartan Losartan Milfasartan Olmesartan Olodanrigan PD123319 Pomisartan Pratosartan Ripisartan Saprisartan Sparsentan Tasosartan Telmisartan Valsartan Zolasartan ACE inhibitors:Alacepril Benazepril Captopril Cilazapril Delapril Enalapril Enalaprilat Fosinopril Gemopatrilat Imidapril Lisinopril Moexipril Omapatrilat Perindopril Quinapril Quinaprilat Ramipril Rentiapril Rescinnamine Spirapril Spiraprilat Temocapril Trandolapril Zofenopril Zofenoprilat Renin inhibitors:Aliskiren Ciprokiren Ditekiren Enalkiren Imarikiren Pepstatin Remikiren Terlakiren Zankiren Propeptides:Angiotensinogen Angiotensin I
Combinations:	Amlodipine/valsartan Olmesartan/amlodipine Olmesartan/amlodipine/hydrochlorothiazide Valsartan/hydrochlorothiazide Valsartan/hydrochlorothiazide/amlodipine

ATRTooltip Angiotensin receptor

Combinations:

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