Talk:Lofexidine
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The website for this drug is located athttp://www.lofexidine.co.uk . I may try expanding this article, but it will be my first edit aside from talk pages. I don't really know the ins and outs of wikipedia at all yet, so it'd be much better if someone else did it. The website doesn't have all that much information, but it's definitely got a lot more then wikipedia does.Tainted4206:31, 9 October 2007 (UTC)[reply]
From what I understand, lofexidine is not clinically equivalent to methadone as purported and the fact that one is commonly used at higher doses than the other is completely meaningless unless were going to discuss the pharmacological mechanism by which they both eliminate the some of the same symptoms (certain withdrawal symptoms). They're not equivalent because methadone provides a whole set of effects that lofexidine does not and they're not even clinically equivalent with regards to withdrawal symptom relief because lofex. does not allievate all the symptoms nor does it provide complete relief. I would simply say that it is a useful aid for mitigating some of the unwanted effects of opioid withdrawal due to its antagonism of alpha-2 andrenergic receptors. -Zach—Precedingunsigned comment added by66.191.120.105 (talk)02:36, 18 August 2008 (UTC)[reply]
Agree with the previous post on clinical equivalence. Additionally, the note on naltrexone being used to *attenuate* withdrawal symptoms is questionable at best, and might lead one to [wrongly] conclude that naltrexone can be used to provide relief from withdrawal in one actively dependent on opioids. Naltrexone is well-known to exacerbate (and indeed, precipitate) withdrawal in such individuals.—Precedingunsigned comment added by12.40.227.4 (talk)15:43, 13 August 2009 (UTC)[reply]
Is this compound a racemate [50% (R)-stereoisomer + 50% (S)-stereoisomer] or the pure (R)-stereoisomer or the pure (S)-stereoisomer? Stereoisomers regulary have a different pharmacology and different pharmacokinetics [E. J. Ariëns: Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology, European Journal of Clinical Pharmacology 26 (1984) 663-668].--Jü (talk)20:22, 14 August 2009 (UTC)[reply]
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