This gene belongs to a family of genes that function as receptors fortachykinins. Receptor affinities are specified by variations in the5'-end of the sequence. The receptors belonging to this family are characterized by interactions withG proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[5]
Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as ananxiolytic andantidepressant.
This article needs to beupdated. Please help update this article to reflect recent events or newly available information.(May 2022)
Maggi CA, Giuliani S, Patacchini R, Santicioli P, Theodorsson E, Barbanti G, Turini D, Giachetti A (Jan 1992). "Tachykinin antagonists inhibit nerve-mediated contractions in the circular muscle of the human ileum. Involvement of neurokinin-2 receptors".Gastroenterology.102 (1):88–96.doi:10.1016/0016-5085(92)91787-5.PMID1370160.
Cyr C, South V, Saltzman A, Felder S, Ricca GA, Jaye M, Huebner K, Kagan J, Croce CM, Schlessinger J (1991). "Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis".Annals of the New York Academy of Sciences.632 (1):426–7.Bibcode:1991NYASA.632..426C.doi:10.1111/j.1749-6632.1991.tb33144.x.PMID1659297.S2CID42849825.
Morten JE, Hopkins B, Powell SJ, Graham A (Dec 1991). "Human NK-2 receptor gene maps to chromosome region 10q11-21".Human Genetics.88 (2):200–3.doi:10.1007/bf00206072.PMID1661704.S2CID328872.
Graham A, Hopkins B, Powell SJ, Danks P, Briggs I (May 1991). "Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends".Biochemical and Biophysical Research Communications.177 (1):8–16.doi:10.1016/0006-291X(91)91940-E.PMID1710456.
Kris RM, South V, Saltzman A, Felder S, Ricca GA, Jaye M, Huebner K, Kagan J, Croce CM, Schlessinger J (Jan 1991). "Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis".Cell Growth & Differentiation.2 (1):15–22.Bibcode:1991NYASA.632..426C.doi:10.1111/j.1749-6632.1991.tb33144.x.PMID1848773.S2CID42849825.
Brunelleschi S, Bordin G, Colangelo D, Viano I (Jun 1998). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis".Neuropeptides.32 (3):215–23.doi:10.1016/S0143-4179(98)90040-3.PMID10189055.S2CID40222022.
Patacchini R, Giuliani S, Turini A, Navarra G, Maggi CA (Jun 2000). "Effect of nepadutant at tachykinin NK(2) receptors in human intestine and urinary bladder".European Journal of Pharmacology.398 (3):389–97.doi:10.1016/S0014-2999(00)00346-0.PMID10862829.
Candenas ML, Cintado CG, Pennefather JN, Pereda MT, Loizaga JM, Maggi CA, Pinto FM (Dec 2002). "Identification of a tachykinin NK(2) receptor splice variant and its expression in human and rat tissues".Life Sciences.72 (3):269–77.doi:10.1016/S0024-3205(02)02240-3.PMID12427486.
Bandari PS, Qian J, Oh HS, Potian JA, Yehia G, Harrison JS, Rameshwar P (May 2003). "Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin-2 promoter".Journal of Neuroimmunology.138 (1–2):65–75.doi:10.1016/S0165-5728(03)00096-1.PMID12742655.S2CID3108613.
Zhao A, Shea-Donohue T (Oct 2003). "PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors".American Journal of Physiology. Gastrointestinal and Liver Physiology.285 (4): G696-703.doi:10.1152/ajpgi.00064.2003.PMID12801882.
"Tachykinin Receptors: NK2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2012-05-31. Retrieved2008-12-09.
