| Airline | State or territory | Image | IATA | ICAO | Callsign | Hubs and focus cities | Commenced operations | Ceased operations | Notes |
|---|
| Q |
| Quaker City Airways | California | | | | | Burbank | 1948 | 1961 | Supplemental air carrier. RenamedAdmiral Airways. OperatedBoeing 307 Stratoliner[1] |
| Queen City Flying Service | Ohio | | | | | Cincinnati/Northern Kentucky | 1940 | 1970 | OperatedBeech 18,C-45 Expeditor[2] |
| Quicktrans | Virginia |  | | | | Norfolk | 1950 | 1994 | Navy cargovirtual airline |
| R |
| Ram Air Freight | North Carolina | | | REX | RAM EXPRESS | Raleigh Durham | 1982 | 2008 | OperatedGrumman Cheetah,Piper Seneca,Piper PA-32 |
| Ramp 66 | South Carolina | | | PPK | | North Myrtle Beach | 1991 | 1994 | OperatedBeech Baron,Beech Bonanza,Cessna 402[3] |
| Ranger Airlines | Texas | | | | | El Paso | 1968 | 1970 | Scheduled third-level services[4] |
| Rankin Flying Service | Oregon | | | | | Swan Island | 1927 | n/a | Founded byTex Rankin[5] |
| Ransome Airlines | Pennsylvania |  | RZ | | | Northeast Philadelphia | 1967 | 1995 | Feeder flights forAllegheny Commuter (1970-1982),Delta Connection (1984-1987),Pan Am Express (1987-1991) andTrans World Express (1991-1995) |
| Rapid Air | |  | | | | | 1965 | 2006 | Cargo operator. Known asSparta Aviation Service |
| Rapid Air Lines | South Dakota | | | | | Rapid City | 1930 | 1933 | Merged withHanford Airlines to formHanford-Rapid Airlines[6] |
| Rapid City Airlines | South Dakota | | | | | Rapid City | 1928 | 1929 | Established asPioneer Airways. OperatedCurtiss Jenny[7] |
| Raritan Valley Air | New Jersey | | | | | Manville | 1966 | 1968 | OperatedBeech 18,Beech Baron,Piper Apache[8] |
| Rasmark Jet Charter | Texas | | | | | El Paso | 1984 | 2000 | OperatedLearjet 25,Falcon 20[9] |
| Raven Air | Alaska | | | | | Anchorage | 1987 | 1992 | OperatedCessna aircraft[10] |
| Ravn Alaska | Alaska |  | 7H | RVF | RAVN FLIGHT | Anchorage | 2014 (traceable to 1948) | 2025 | Shutdown due to travel disruptions caused by theCOVID-19 pandemic, |
| Ray Petersen Flying Service | Alaska | | | | | Bethel | 1937 | 1945 | AcquiredBristol Bay Air Service andJim Dodson Air Service[11] |
| RCR Air | North Carolina | | | | | Lexington | 2007 | 2014 | OperatedEmbraer ERJ 145[12] |
| Reading Aviation Service | Pennsylvania | | | | | Reading | 1966 | 1966 | Operatedde Havilland Dove,Beech D18S[13] |
| Rectrix Aviation | Massachusetts | | | | | Nantucket | 2005 | 2019 | |
| Red Arrow Flying Service | Florida | | | | | Miami | 1917 | 1919 | Renamed toChalk's Flying Service OperatedStinson Voyager with floats[14][15] |
| Red Baron Airlines | Florida | | | | | Palm Beach | 1979 | 1980 | Renamed toFlorida Commuter Airlines |
| Red Carpet Airlines | Florida | | | RED | | Clearwater | 1978 | 1981 | RenamedAerosun International. OperatedConvair 340,DC-3[16] |
| Red Dodge Aviation | Alaska | | | | | Anchorage | 1969 | 1972 | uncertificated carrier flyingLockheed L-100 Hercules. Subsidiary ofFlying W Airways |
| Red Way | Nebraska |  | | | | Lincoln | 2023 | 2023 | Virtual airlne |
| Red Wing Flying Service | Massachusetts | | | | | Ware | 1929 | 1929 | Air taxi[5] |
| Rediske Air | Alaska | | | | | Soldotna | 1991 | 2017 | |
| Redline Air Charters | Alaska | | | | | Ruby | 1996 | 2010 | [17] |
| Reeve Aleutian Airways | Alaska |  | RV | RVV | REEVE | Anchorage | 1932 | 2001 | |
| Regent Air | California | | | | | Los Angeles | 1983 | 1986 | Established asFirst Air. OperatedBoeing 727[18] |
| Regina Cargo Airlines | Florida |  | | | | Miami | 1948 | 1960 | Supplemental air carrier changed its name toImperial Airlines in 1960 |
| RegionsAir | Tennessee | | 3C | CEA | CORP-X | Smyrna | 1996 | 2007 | |
| Reilly Air Service | California | | | | | Los Angeles | 1968 | 1971 | OperatedBeech 18[19] |
| Reliant Airlines | Michigan |  | | RLT | | | 1984 | 2002 | |
| Reno Air | Nevada |  | QQ | ROA | RENO AIR | Reno–Tahoe | 1992 | 1999 | Merged intoAmerican Airlines |
| Reno Air Express | California | | | | | San Jose | 1994 | 1995 | [20] |
| Renown Aviation | California | | RG | RGS | | Santa Maria | 1980 | 2000 | Established asWestern Aircraft Salvage[21] |
| Republic Airlines | Minnesota |  | RC | REP | REPUBLIC | Minneapolis–Saint Paul | 1979 | 1986 | Merged intoNorthwest Airlines |
| Resort Air | Missouri | | | | | St. Louis Lambert | 1983 | 1989 | Renamed toTrans States Airlines. OperatedSwearingen Metro[22] |
| Resort Air | Rhode Island | | | | | Block Island | 1990s | 1990s | Charter carrier[23] |
| Resort Air | Oregon | | | | | Sunriver | 1992 | 1992 | Scenic tours[24] |
| Resort Airlines | North Carolina Florida District of Columbia |  | RA | RA | | Pinehurst, North Carolina New York City Miami | 1945 | 1960 | Scheduled international carrier limited to "sky cruises" |
| Resort Airlines | Maryland | | | | | Baltimore–Washington | 1982 | 1986 | OperatedPiper aircraft[25] |
| Resort Airways | Hawaii | | | | | Honolulu | 1960 | 1971 | Absorbed byHATS Hawaiian Air Tour Service. OperatedAero Commander 500[26] |
| Resort Commuter | California | | | | | Orange County | 1988 | 1995 | OperatedConvair 580[27] |
| Resort Commuter Airlines | South Carolina | | | | | | 1975 | 1979 | Renamed toMid-South Airlines[28] |
| Resort Commuter Airlines | California | | XK | | | Orange County | 1984 | 1989 | Established asCatalina Commuter[29] |
| Rhoades International | Indiana | | | RDS | | Columbus | 1989 | 2006 | Renamed toRhoades Aviation. OperatedConvair C-131,Convair 240,DC-3,Douglas DC-6[30] |
| Rich International Airways | Florida |  | JN | RIA | RICHAIR | Miami | 1970 | 1996 | |
| Richmond Aviation | Virginia | | | | | Richmond | 1963 | 1971 | OperatedPiper Twin Comanche,Twin Bonanza,Mitsubishi MU-2[31] |
| Riddle Airlines | Florida |  | | | | Miami | 1945 | 1965 | Rebranded asAirlift International |
| Rio Airways | Texas |  | XO | REO | RIO | Skylark Field | 1967 | 1986 | Began asHood Airlines |
| Rio Grande Air | | | | | | | 1999 | 2003 | Cessna Caravan operator |
| RKO General | Massachusetts | | | | | | 1968 | 1970 | Helicopter air taxi. OperatedBell 47,Bell 206[32] |
| Robertson Aircraft Corporation | Missouri | | | | | Lambert Field | 1925 | 1929 | [33] |
| Robin Airlines | California | | | | | Long Beach | 1950 | 1951 | Renamed toNorth Continent Airlines[34] |
| Robinson Airlines | New York | | | | | Ithaca | 1945 | 1952 | Renamed toMohawk Airlines[35] |
| Roblex Aviation | Puerto Rico |  | | ROX | | San Juan | 1997 | 2013 | Cargo operator[36] |
| Rochester Aviation | Minnesota | | | | | Rochester | 1969 | 1971 | OperatedCessna 206[37] |
| Rockford Air Charter | Illinois | | | | | Chicago Rockford | 1964 | 1971 | OperatedCessna 206,Beech 18,Piper Twin Comanche[38] |
| Rocky Mountain Airways | Colorado |  | JC | RMA | ROCKY MOUNTAIN | Denver Stapleton | 1965 | 1991 | Began asVail Airways. Merged intoContinental Express |
| Rogers Heavy Lift Helicopters | California | | | | | Fresno Yosemite | 1994 | 1998 | OperatedSikorsky CH-54 Tarhe[39] |
| Roscoe Turner Aeronautical Corporation | Georgia | | | | | Candler Field | 1925 | 1928 | OperatedSikorsky S-29-A |
| Rose Aviation | California | | | | | Hawthorne | 1968 | 1969 | OperatedPiper Apache,Aero Commander 500[40] |
| Rosenbalm Aviation | Massachusetts | | | RAX | ROSIE | Willow Run | 1973 | 1991 | BecameFlagship Express Services. OperatedConsolidated PBY Catalina,DC-6,DC-8-63F[41] |
| Roseswift Air Service | Michigan | | | | | Grand Rapids | 1920 | 1920 | Founded by Arthur Rosenthal and Thomas Swift. OperatedCurtiss Jenny[42] |
| Roswell Airlines | New Mexico | | | | | Roswell | 1976 | 1981 | Founded by Dick Callens. OperatedPiper Seneca[43] |
| Roust Airways | Alaska | | | | | Nome | 1930 | 1935 | Founded by Thomas Pedersen Roust[44] |
| Royal Air | Missouri | | | | | Kansas City | 1978 | 1980 | OperatedEmbraer Bandeirante[45] |
| Royal American Airlines | Arizona |  | | | | Tucson | 1977 | 1986 | OperatedVickers Viscount[46][47] |
| Royal American Airways | | | | RLM | | | 1981 | 1993 | OperatedConvair 240,Convair 600,Vickers Viscount[48] |
| Royal Hawaiian Air Service | Hawaii |  | ZH | | | | 1971 | 1986 | Established asHawaii Wings in 1963. OperatedCessna 402C[49] |
| Royal Hawaiian Airlines | Hawaii | | | | | Honolulu | 1985 | 1986 | [50] |
| Royal West Airlines | Nevada | | | | | Las Vegas McCarran | 1981 | 1982 | OperatedDC-3[51] |
| Royal West Airlines | Colorado |  | | RWE | ROYAL WEST | Colorado Springs | 1981 | 1987 | Merged withAero West Airlines in 1982. OperatedDC-3,BAe 146[52] |
| Royal West Airlines | Nevada | | | | | Las Vegas McCarran | 1986 | 1987 | [53] |
| Royal-Air | Arkansas | | | | | Goodwin Field | 1982 | 1982 | Established asJamaire. Renamed toSunbelt Airlines[54] |
| Royale Airlines | Louisiana |  | OQ | RAY | ROYALE AIR | New Orleans Armstrong | 1968 | 1989 | |
| Rugby Aviation | Washington | | | | | Seattle-Tacoma | 2002 | 2007 | Renamed toNorthwest Sky Ferry[55] |
| Russia Jet Direct | Washington | | RD | RYN | | Seattle–Tacoma | 2005 | 2005 | |
| Ryan Air | Alaska | | | | | Anchorage | 1979 | 1988 | Established asUnalakleet Air Taxi. Renamed toArctic Transportation Services[56] |
| Ryan Airline Company | California | | | | | San Diego | 1925 | 1926 | |
| Ryan International Airlines | Illinois |  | RD | RYN | RYAN | Chicago Rockford | 1972 | 2013 | |
| S |
| S.I. Airways | Texas | | | | | Amarillo | 1974 | 1975 | [57] |
| S.S. Airways | Kansas | | | | | Amarillo | 1972 | 1972 | Renamed toCentury Airlines[58] |
| S.S.W. | Texas |  | | | | El Paso | | 1959 | Supplemental air carrier shut by CAB in 1959 for stranding passengers due to lack of funds.dbaUniversal Airlines 1957–1959 |
| Saber Aviation | | | SP | SBR | | | 1978 | 1991 | [59] |
| Safeway Airlines | Alaska | | | | | Fairbanks | 1964 | 1968 | OperatedPiper Apache,Piper Comanche,Cherokee Six[60] |
| Sair | New York | | | | | Syracuse | 1961 | 1999 | [61] |
| Salair | Alaska |  | 8S | SIR | | Anchorage | 1980 | 1997 | OperatedDC-3,Convair 440. Renamed toAir Alaska Cargo |
| Salmon Air | Idaho |  | S6 | MBI | | Boise | 1968 | 2009 | Merged intoMcCall Aviation |
| Samoa Air | American Samoa | | | | | Pago Pago | 1987 | 2003 | |
| Samoan Airlines | American Samoa | | SX | SX | | Pago Pago | 1959 | 1960 | CAB-certificated as an intl carrier. |
| San Diego Sky Freight | California | | | | | San Diego | 1950 | 1952 | Cargo operator[62] |
| San Francisco and Oakland Helicopter Airlines | California |  | OH | | SFO AIRLINES | San Francisco | 1961 | 1986 | |
| San Juan Airlines | Washington |  | | | | Port Angeles | 1947 | 1989 | Commuter operator[63] |
| San Juan Airlines | | | YS | | | | 1970 | 1989 | Merged intoAlaska Airlines[64] |
| San Marino Taxi Aereo | California | | | | | Long Beach | 1999 | 2003 | [65] |
| Santa Fe Airline Company | New Mexico | | | | | Santa Fe | 1972 | 1972 | Intrastate air carrier[66] |
| Santa Fe Skyway | | | | | | | 1946 | 1947 | [67] |
| Santa Maria Airlines | California | | | | | Hancock Field | 1928 | 1935 | Founded byGeorge Allan Hancock[68] |
| SAT-Air | Texas | | | | | San Antonio | 1983 | 1995 | Renamed toMerlin Express[69] |
| Satellite Aero | Wyoming | | | | | Jackson Hole | 1990 | 1995 | OperatedCessna 206,Cessna 402C,Piper Navajo[70] |
| Saturn Airways | California |  | KS | | | Oakland | 1960 | 1976 | All American Airways until 1960.Supplemental air carrier. Merged intoTrans International Airlines |
| Sawyer Aviation | Arizona | | | | | Phoenix Sky Harbor | 1961 | 1998 | OperatedCessna 182,Cessna 425C,Cessna Citation[71] |
| SB Air | Texas | | | | | Dallas Love Field | 1999 | 2019 | Established asSeven Bar Flying Services. Renamed toSevenBar Aviation. Medical transport operator.[72] |
| Scanderbeg Air | New York | | P1 | | | New York Kennedy | 2009 | 2009 | Charter carrier[73] |
| SCAT South Central Air Transport | Arkansas | | | | | Fayetteville | 1946 | 1948 | OperatedCessna UC-78[74] |
| Scenic Air | California | | | | | Columbia | 1994 | 1995 | [75] |
| Scenic Air Tours Hawaii | Hawaii | | | | | Honolulu | 1992 | 1996 | [76] |
| Scenic Airlines | Nevada | | YR | YRR | | North Las Vegas | 1967 | 2007 | Acquired byGrand Canyon Airlines and renamed toGrand Canyon Scenic Airlines[77] |
| Scenic Airways | Arizona | | | | | Grand Canyon | 1927 | 1930 | Renamed toGrand Canyon Airlines[78] |
| Scheduled Skyways | Arkansas |  | | | | Fayetteville | 1953 | 1972 | Merged intoAir Midwest |
| Scheerer Air | Florida | | | | | Palm Beach | 1979 | 1980 | Merged intoFlorida Commuter Airlines[79] |
| Seaboard & Western Airlines | New York |  | | | | New York Kennedy | 1947 | 1961 | Renamed toSeaboard World Airlines[80] |
| Seaboard World Airlines | New York |  | SB | SEW | SEABOARD | New York Kennedy | 1946 | 1980 | As Seaboard & Western Airlines, merged intoFlying Tiger Line |
| Seaco Airlines | Michigan | | | | | Detroit Metro | 1976 | 1980 | OperatedCessna 402,Piper Aztec[81] |
| Seacoast Air Transport | Massachusetts | | | | | New Bedford | 1937 | 1939 | [82] |
| SeaCoast Airlines | Florida | | | SCC | SEA-COASTER | St. Pete–Clearwater | 2002 | 2012 | |
| Seagull Air | Alaska | | | | | Bethel | 1988 | 1989 | Founded byJ. Timothy Cracie[83] |
| Seagull Air Lines | Utah | | | | | Salt Lake City | 1929 | 1930 | OperatedCurtiss Robin[84] |
| Seair Alaska Airlines | Alaska | | | | | Anchorage | 1980 | 1986 | Established asSea Airmotive. OperatedConvair 440,Twin Otter[85] |
| Seaplanes of Key West | Florida | | | | | Key West | 2004 | 2006 | [86] |
| SeaPort Airlines | Oregon |  | K5 | SQH | SASQUATCH | Portland | 2008 | 2016 | Went into bankruptcy[87] |
| Seattle Air Charter | Washington | | | | | Seattle-Tacoma | 1947 | 1949 | [88] |
| Seattle Commuter Airlines | Washington | | | | | Seattle-Tacoma | 1965 | 1968 | Scheduled commuter air services[89] |
| Seattle Flying Services | Washington | | | | | Seattle | 1930 | 1930 | Founded byVern Gorst[90] |
| Seattle-Victoria Airmail Line | Washington | | | | | Seattle | 1919 | 1919 | Established asHubbard Air Transport[91] |
| Sentinel Airlines | Texas | | | | | Abilene | 1971 | 1971 | OperatedCessna 402[92] |
| Seven Bar Flying Services | Texas | | | | | Dallas Love Field | 1947 | 1999 | Medical transport operator. RenamedSB Air[93] |
| Seven Seas Airlines | California | | | | | Burbank | 1957 | 1961 | OperatedC-46,DC-4[94] |
| Severson Air Activities | Montana | | | | | Great Falls | 1964 | 1971 | OperatedCessna 182,Cessna 320[95] |
| Seward Airways | Alaska | | | | | Seward | 1937 | 1939 | Founded byJohn Littley[96] |
| Shalkow Air Cargo Express | Ohio | | | | | Cleveland Hopkins | 1982 | 1989 | Established asAce Air Cargo Express. OperatedC-47[97] |
| Shasta Air | California | | | | | Yreka Rohrer Field | 1968 | 1983 | OperatedPiper Navajo[98] |
| Shavano Air | Colorado | | | SHV | SHAVANO | Harriet Alexander Field | 1960 | 2002 | |
| Shawnee Airlines | Florida | | XW | SHW | SHAWNEE | Orlando Executive | 1968 | 1975 | Acquired byFlorida Airlines[99] |
| Shawnee Airways | Ohio | | | | | Akron–Canton | 1961 | 1972 | Founded byErnest Stadvec[100] |
| Sheffield P. Wilds | South Carolina | | | | | | 1967 | 1971 | OperatedAero Commander 500,Piper Apache[101] |
| Shelby Sky Haven | Ohio | | | | | Mansfield | 1948 | 1963 | Renamed toGCS Air Service[102] |
| Shelter Charter Services | Georgia | | | | | Atlanta | 2017 | 2017 | OperatedCessna Citation I[103] |
| Shelton-Jefferson Airways | Missouri | | | | | St. Louis Lambert | 1930 | 1931 | OperatedOgden Osprey[5] |
| Shenandoah Airlines | Virginia | | | | | Charlottesville–Albemarle | 1968 | 1970 | OperatedBeech E18S[104] |
| Shoreline Aviation | Connecticut | | | | | Tweed New Haven | 1980 | 2020 | OperatedCessna Caravan seaplane[105] |
| Shorter Airlines | Michigan | | | | | Pellston Regional | 1968 | 1975 | OperatedBeech E18S,DC-3[106] |
| Shuttle Air Lines | California | | | | | Glendale Grand Central | 1931 | 1932 | OperatedOgden Osprey[5] |
| Shuttle America | Indiana |  | S5 | TCF | MERCURY | Chicago O'Hare | 1995 | 2017 | Republic Airways Holdings merged into another subsidiary |
| Shuttle by United | California |  | UA | UAL | UNITED | San Francisco | 1994 | 2001 | Subsidiary ofUnited Airlines, renamedUnited Shuttle |
| Sidles Airways | Nebraska | | | | | Lincoln | 1930 | n/a | OperatedStinson Detroiter (NC7474)[5] |
| Siemans Air Transport | Pennsylvania | | | | | Uniontown | 1927 | n/a | Founded byCharles L. Siemans[5] |
| Sierra Expressway | California | | | SRX | SIERRA EX | Oakland | 1994 | 1996 | [107] |
| Sierra Mountain Airways | California | | | | | Oakland | 1987 | 1989 | [108] |
| Sierra Nevada Airways | Nevada | | ZS | | | Las Vegas McCarran | 1984 | 1997 | OperatedBeech Baron,Cessna 402C[109] |
| Sierra Pacific Airlines | California |  | | | | Oakland | 1965 | 1966 | OperatedBeech 18[110] |
| Sierra Pacific Airlines | Arizona | | | | | Tucson | 1976 | 1982 | [111] |
| Sierra West Airlines | California | | | | | Van Nuys | 1974 | 1975 | OperatedBeech Queen Air[112] |
| Silver State Airlines | Nevada | | | | | Las Vegas McCarran | 1979 | 1982 | Charter carrier[113] |
| Silver State Helicopters | Nevada | | | | | Henderson Executive | 1999 | 2008 | |
| Silver Wings Aviation | South Dakota | | | | | Rapid City | 1975 | 1976 | [114] |
| Silver Airways | Florida | | | | SILVER | Tampa | 2011 | 2025 | |
|
| Simmons Airlines | Michigan |  | MQ | SYM | SIMMONS | Marquette | 1978 | 1998 | Merged intoAmerican Eagle Airlines |
| Sis-Q Flying Service | California | | | | | Sonoma County | 1962 | 1979 | Aerial fire fighting. OperatedGrumman Tigercat[115] |
| Sisk Aviation Activities | Illinois | | | | | St. Louis Downtown | 1964 | 1977 | Third-level services[116] |
| Sizer Airways | North Dakota | | | | | Fargo-Hector Field | 1970 | 1979 | Established asLuthi Aviation. OperatedBeech 18,Riley Rocket[117] |
| Skagway Air Service | Alaska | | 7J | SGY | | | 1964 | 2007 | [118] |
| Sky Bus Public Charter | Florida | | | | | Fort Lauderdale | 1993 | 1993 | OperatedBoeing 727-200[119] |
| Sky Courier | | | | | | | 1988 | 1988 | ToAirborne Express[120] |
| Sky Harbor Air Service | Nebraska | | NE | SKD | SKY DAWG | Omaha | 1954 | 1970 | [121] |
| Sky Harbor Air Services | Wyoming | | WY | SHC | SKY HARBOR CHEYENNE | Cheyenne | 1988 | | [122] |
| Sky King | Florida |  | 5K | SGB | SONGBIRD | Miami | 1990 | 2015 | Rebranded asSongbird Airways |
| Sky Tours | Massachusetts | | | | | | 1947 | 1953 | Established asErie Isle Airways. Renamed toIsland Airlines[123] |
| Sky Tours Hawaii | Hawaii | | | | | | 1965 | 1971 | [124] |
| Sky Trek International Air Lines | Virginia |  | | | | Richmond | 1996 | 2000 | RenamedDiscovery Airways in 1999 |
| Sky Trucks International | Florida | | | | | Fort Lauderdale | 1972 | 1975 | [125] |
| Skybus Airlines | Ohio |  | SX | SKB | SKYBUS | Columbus | 2007 | 2008 | |
| Skybus Express | Georgia | | | | | Atlanta | 1991 | 1992 | OperatedGAF Nomad |
| Skycoach | California |  | | | | | | | 1950scombine. Aircraft in picture isMonarch Air Service orCurrey Air Transport |
| Skyfreighters | Texas | | | | | Grand Prairie | 1984 | 1991 | Established asCoker Airfreight. Acquired byKitty Hawk Airways. OperatedDouglas C-117D[126] |
| Skyfreight Airlines | Florida |  | | | | Miami | 1981 | 1984 | OperatedDC-3[127] |
| Skyline Air Service | Washington | | | | | Seattle-Tacoma | 1967 | 1969 | Founded by Tom Wilson. ToPuget Sound Airlines[128] |
| Skyline Motors Aviation Services | Ohio | | | | | Youngstown–Warren | 1979 | 1981 | Renamed toB.A.S Airlines[129] |
| Skylink Airways | Maryland | | | | | Washington Dulles | 2003 | 2005 | Rebranded asMAXjet Airways |
| Skymark Airlines | California |  | | | | Sacramento Executive | 1968 | 1969 | [130] |
| Skymaster Air Taxi | New Hampshire | | 8M | SDD | SKY DANCE | Laconia | 1989 | 1993 | RenamedAtlantic North Airlines[131] |
| Skyservice USA | Colorado |  | | | | Chicago Rockford | 1998 | 2000 | |
| Skystar International | Virginia |  | | SSK | | Washington National | 1984 | 1987 | International pilgrimage[132] |
| Skystream Airlines | Illinois | | DN | | | Chicago Meigs Field | 1973 | 1980 | Founded byCecil Pond. AcquiredHub Airlines[133] |
| SkyValue | Florida | | XP | CXP | RUBY MOUNTAIN | Fort Lauderdale-Hollywood | 2006 | 2007 | |
| SkyValue Airways | Michigan | | 4A | DYN | | Oakland County | 2018 | 2018 | [134] |
| Skyvan Airways | | | | | | | 1963 | 1964 | OperatedC-46[135] |
| Skyway Airlines (Skyway Aviation) | Missouri | | ZY | | | Forney Field | 1960 | 1979 | Air taxi operator[136] |
| Skyway Airlines | | | | | | | 1968 | 1980 | Known asSkyway Commuter. OperatedBeech E18S[137] |
| Skyway Airlines | Wisconsin | | AL | SYX | SKYWAY-EX | Milwaukee Mitchell | 1994 | 2008 | |
| Skyway Commuter | Florida | | | | | Ocala | 1984 | 1985 | Established adSkyway of Ocala[138] |
| Skyway of Ocala | Florida | | | | | Ocala | 1981 | 1984 | Operated asAir Florida Commuter[139] |
| Skyways International | Florida | | | | | Miami | 1946 | 1951 | OperatedC-46,DC-3,Lockheed Lodestar[140] |
| Skyways International | Florida | | | | | Miami | 1969 | 1972 | Renamed toTransair Cargo[141] |
| Skyways International | Texas | | | | | Houston Bush | 1978 | | [142] |
| Skyworld Airlines | Colorado |  | PC | SPC | | Denver | 1986 | 1992 | FormerlyDenver Ports of Call |
| Slick Airways | Texas |  | SL | SL | | Hollywood Burbank | 1946 | 1966 | ToAirlift International |
| Slocum Airlines | Florida | | | SLO | SLOCUM | Miami | 1981 | 1984 | Operated asAir Florida Commuter[143] |
| Small Community Airlines | Florida | | | | | Dallas Love Field | 2007 | 2009 | OperatedBAE Jetstream[144] |
| SMB Stage Lines | Texas | | MJ | STG | STAGE | Dallas Fort Worth | 1967 | 1990 | OperatedConvair 580,Convair 600,DC-3[145] |
| Smokers Express | Florida | | | | | Melbourne Orlando | 1993 | 1993 | Not launched |
| Smyer Aircraft | Kansas | | | | | Strother Field | 1968 | 1972 | OperatedCessna 206,Cherokee Six[146] |
| Solar Airlines | New Mexico | | | | | Roswell | 1964 | 1971 | OperatedBeech 18,Dumod Infinité I,PacAero Tradewind[147] |
| Soldotna Air Service | Alaska | | | | | Soldotna | 1978 | 1979 | [148] |
| Song | Georgia |  | DL | DAL | DELTA | Atlanta | 2003 | 2006 | Merged back in with its parent company,Delta Air Lines |
| Songbird Airways | Florida | | 6K | SGB | SONGBIRD | Orlando | 1990 | 2017 | Began asSky King Inc.[149] |
| Sonora Air Lines | Nevada | | | | | Reno–Tahoe | 1967 | 1971 | OperatedCessna 150,Cessna 172,Piper PA-23[150] |
| Sourdough Air Transport | Alaska | | | | | Fairbanks | 1953 | 1962 | [151] |
| South Atlantic Airlines | South Carolina | | | | | Myrtle Beach | 1968 | 1969 | OperatedAero Commander 500,Turbo Commander 690[152] |
| South Bend Airways | Indiana | | | | | Cadet Field | 1927 | n/a | Founded byStephen Darius, Carl G Jordan. OperatedPheasant H-10[5] |
| South Central Air | Alaska | | | SCA | | Kenai | 1967 | 2001 | Founded by Harold and Irene Andersen. OperatedBAe Jetstream 31,BN Islander,Cessna[153] |
| South Central Air Transport (SCAT) | Mississippi | | | | | Natchez–Adams | 1971 | 1977 | [154] |
| South Central Airlines | Florida | | | | | Ocala | 1963 | 1964 | [155] |
| South East Airlines | |  | | | | | | | The name of a 1950scombine, in whose name associated carriers flew. |
| South Pacific Air Lines | California |  | | | | Honolulu | 1960 | 1963 | Merged intoPan Am in 1964 |
| South Pacific Island Airways | Hawaii | | HK | SPI | SOUTH PACIFIC | Honolulu | 1973 | 1987 | |
| South Winds Cargo | Florida |  | WE | SWC | | Miami | 2002 | 2005 | Merged intoCenturion Cargo. OperatedDC-10 |
| Southcentral Air | Alaska |  | XE | SCA | SOUTH CENTRAL | Kenai | 1975 | 1999 | [156] |
| Southeast Airlines | Tennessee | | SL | | SOUTHEAST | Tri-Cities | 1956 | 1959 | [157] |
| Southeast Airlines | Florida |  | NS | SEA | SOUTHEAST AIR | Miami | 1966 | 1981 | Originally known asCat Cay Airlines[155] |
| Southeast Airlines | Florida |  | Sl | SNK | | Youngstown–Warren | 1999 | 2004 | |
| Southeast Airlines (Southeastern Aviation) | Tennessee | | | | | Jackson | 1960 | 1979 | Operatedde Havilland Dove[158] |
| Southeast Skyways | Alaska | | SE | | | Juneau | 1968 | 1983 | Founded by Dean Williams and Billy Bernhardt. OperatedCessna 207,DHC Beaver[159] |
| Southeastern Commuter Airlines | Georgia | | | | | Atlanta | 1973 | 1983 | Acquired byAtlantic Southeast Airlines |
| Southern Air Transport (1929) | Texas | | | | | | 1929 | 1929 | Controlled byAvco, the company that organizedAmerican Airlines |
| Southern Air Transport | Florida Ohio |  | SJ | SJM | SOUTHERN AIR | Miami Columbus, Ohio | 1947 | 1998 | CIA-owned 1960–1973. Assets becameSouthern Air |
| Southern Airlines | Florida | | | | | | 1981 | 1981 | RebrandingFlorida Commuter Airlines[160] |
| Southern Airlink | Mississippi | | | | | Bay Springs | 1996 | 1997 | [161] |
| Southern Airways | Georgia |  | SO | SO | SOUTHERN | Atlanta | 1949 | 1979 | Merged withNorth Central Airlines to formRepublic Airlines (1979–1986) |
| Southern Airways | Mississippi | | | | | Jackson–Medgar | 1985 | 1987 | Established aFlight Line[162] |
| Southern Aviation | Oklahoma | | | | | Lawton | 1964 | 1974 | OperatedCessna 182,Cessna 206[163] |
| Southern Cross Airways | | | | | | | 1959 | 1960 | OperatedC-46[164] |
| Southern Express | Florida | | | | | | 1984 | 1986 | Formerly known asFinair Express[165] |
| Southern International Airways | Florida | | | | | | 1981 | 1981 | Successor ofFlorida Airlines operated asAir Florida Commuter[166] |
| Southern Jersey Airways | New Jersey | | 6J | ALC | ACOM | Cape May | 1946 | 1991 | Established asAtlantic City Airlines operating asAllegheny Commuter[167] |
| Southern Jersey Resorts Airways | New Jersey | | | | | Atlantic City | 1965 | 1990 | OperatedTwin Otter,Dash-8[168] |
| Southern Maryland Aviation | Maryland | | SF | | | St. Mary's County | 1977 | 1979 | [169] |
| Southern Nevada Airlines | Nevada | | | | | | 1980 | 1981 | [170] |
| Southern Skyways | Georgia | | | | | Atlanta | 1980 | | Avirtual airline (economics) which markets air travel branding |
| Southwest Air Fast Express | Oklahoma |  | | | | St. Louis Lambert | 1928 | 1929 | Acquired byAmerican Airlines |
| Southwest Airlines | Texas | | | | | San Antonio | 1965 | 1967 | Established asWild Goose Flying Service[171] |
| Southwest Airways | California |  | | | | San Francisco | 1941 | 1958 | Local service carrier renamed toPacific Air Lines |
| Southwest Ryan Airlines | Indiana | | | | | McIntyre Field | 1928 | n/a | OperatedRyan Brougham[5] |
| Special Aviation Systems | Michigan | | | | | | 2001 | 2004 | Cargo carrier. OperatedEmbraer Bandeirante[172] |
| Speed Star Express | California | | | | | | 1968 | 2005 | OperatedTwin Otter[173] |
| Spirit Air | Alaska | | | | | | 2005 | 2009 | Commuter and package carrier[174] |
| Spirit Aviation | California | | | | | Van Nuys | 1994 | 1995 | Charter operator[175] |
| Spirit Lake Airways | Iowa | | | | | Spencer | 1977 | 1979 | Renamed toGreat Lakes Airlines[176] |
| Spirit of America Airlines | California | | IM | IAS | BOXHALUER | Los Angeles | 1959 | 1989 | Established asIASCO[177] |
| Spokane Airways | Washington | | | | | Spokane | 1990 | 2012 | [178] |
| Sports Air Travel | Oregon | | | WCC | WEST COAST | Portland–Troutdale | 1982 | 1999 | [179] |
| Sports Air Travel | California | | | | | Burbank | 1997 | 1997 | ToAmeriflight[180] |
| Sports by Air | South Carolina | | | | | Hilton Head | 1968 | 1971 | OperatedAero Commander 680[181] |
| Sportsflight Airways | Arizona | | | | | Tucson | 1993 | 1995 | Renamed toPacific International Airlines[182] |
| St. Germain Aviation | Illinois | | | | | Meigs Field | 1964 | 1971 | OperatedPiper Twin Comanche[183] |
| St. Petersburg–Tampa Airboat Line | Florida |  | | | | St. Petersburg | January 1914 | May 1914 | Benoist Type XIV |
| Stadvec Aviation | Illinois | | | | | Akron–Canton | 1958 | 1961 | Founded byErnest Stadvec. OperatedPiper PA-22 Tri-Pacer[184] |
| Stagecoach Airways | Texas | | | | | San Antonio | 1958 | 1961 | OperatedBeech Twin Bonanza,Lockheed L.12 Electra[185] |
| Standard Air Cargo | California |  | | | | San Diego | 1946 | 1953 | Original name ofStandard Airways |
| Standard Air Lines | California | | | | | Los Angeles | 1927 | 1930 | Subsidiary ofAero Corporation of California. In 1930 acquired byWestern Air Express |
| Standard Air Lines | California |  | | | | Long Beach | 1945 | 1949 | Established asFireball Air Express |
| Standard Airways | California |  | FD | | | San Diego Burbank | 1946 | 1969 | Established asStandard Air Cargo |
| Standard Airways | Michigan | | | | | Pontiac | 1966 | 1969 | OperatedBeech 18,Piper Navajo[186] |
| Star Air Service | Alaska |  | | | | Anchorage | 1932 | 1944 | Renamed toAlaska Airlines |
| Starflight | Nevada | | | | | Reno–Tahoe | 1975 | 1975 | OperatedBAC One-Eleven[187] |
| Starlight Express | | | | | | | 1987 | 1991 | Cargo feeder forFedEx Express[188] |
| Starflite | New York | | | | | White Plains | 1965 | 1966 | Contract service operator[189] |
| Starship Airlines | Arizona | | | | | Tucson | 1991 | 2000 | OperatedConvair 240C,Convair 440F[190] |
| Starstruck Jet | Tennessee | | | | | Nashville | 1998 | 1998 | [191] |
| State Airlines | South Carolina | | | | | Charlotte Douglas | 1940 | 1940 | OperatedLockheed Lodestar,Bellanca Cruisair[5] |
| State Airlines | Florida | | | | | Ft. Lauderdale | 1981 | 1984 | [192] |
| StatesWest Airlines | Arizona |  | YW | SWJ | STATES | Phoenix Sky Harbor | 1986 | 1993 | |
| Stateswide Airline | New Hampshire | | | | | Manchester–Boston | 1964 | 1965 | Operatedde Havilland Dove[193] |
| Stearns Air Alaska | Alaska | | | | | Anchorage | 1992 | 2001 | [194] |
| Stewart Air Service | California | | | | | Los Angeles | 1946 | 1971 | [195] |
| Stol Air Commuter | California | | VB | | | Fresno Yosemite | 1972 | 1978 | RenamedWestAir Commuter Airlines[196] |
| Stout Air Services | Michigan | | | | | Ford Airport | 1925 | 1930 | Purchased byNational Air Transport |
| Strachan Skyways | Georgia | | | | | Hunter Field | 1936 | 1938 | [197] |
| Streamline Air | Massachusetts | | | SRY | STINGRAY | Hanscom Field | 2010 | 2012 | |
| Suburban Airlines | |  | AL | | | DuBois | 1968 | 1989 | ToAllegheny Airlines |
| Suburban Airways | California |  | | | | | | | |
| Summit Airlines | Pennsylvania | | DU | SMM | SUMMITAIR | Philadelphia | 1966 | 1986 | Established asDel Air Cargo Airlines[198] |
| Summit Airways | Colorado | | | | | Denver | 1946 | 1947 | Established asChallenger Airlines[199] |
| Summit Aviation | Florida | | | | | Miami | 1999 | 1999 | Charter operator[200] |
| Sumo Airlines | New York | | SM | | | New York Kennedy | 1988 | 1996 | Cargo operator. OperatedPiper Lance[201] |
| Sun Air Express | Florida | | | | | Fort Lauderdale | 2014 | 2016 | Acquired bySouthern Airways Express[202] |
| Sun Air International | Florida |  | | | | Fort Lauderdale-Hollywood | 2011 | 2014 | Rebranded asSun Air Express |
| Sun Aire Lines | California | | OO | | | Palm Springs | 1968 | 1984 | Established asBorrego Springs Airlines. Merged intoSkyWest Airlines |
| Sun Airlines | Missouri | | | | | St. Louis Lambert | 1967 | 1970 | Founded byGeorge Caleshu. OperatedBeech 18,Twin Otter,de Havilland Heron[203] |
| Sun Airlines | Florida | | YX | | | | 1969 | 1978 | [204] |
| Sun Jet International | Florida |  | JX | SJI | SUNJET | St. Pete–Clearwater | 1993 | 1997 | Founded byTom Kolfenbach. Renamed toSoutheast Airlines[205] |
| Sun Land Airlines | Nevada |  | RF | | | Reno | 1980 | 1981 | Operated singleBoeing 737-200[206] |
| Sun Pacific International | Arizona | | | SNP | | Tucson | 1995 | 1999 | OperatedBoeing 727-200[207] |
| Sun Valley Airlines | Utah | | | | | Salt Lake City | 1964 | 1972 | Established asJanss Airways in 1964. Acquired byKey Airlines[208] |
| Sun Valley Key Airlines | Idaho |  | | | | Friedman Memorial | 1968 | 1972 | FormerlySun Valley Airlines renamed toKey Airlines |
| Sun West Airlines | Arizona | | KY | SNW | SUN WEST | Phoenix Sky Harbor | 1980 | 1985 | |
| Sunaire Express | Virgin Islands | | OY | SUA | SUNBIRD | Saint Croix Rohlsen | 1982 | 1994 | Went bankrupt[209] |
| Sunbelt Airlines | Arkansas | | JM | BTR | | Harrell Field | 1979 | 1984 | Known asJamaire until March 1982[210] |
| Sunbird Air | Florida | | | | | Fort Lauderdale | 1984 | 1989 | OperatedConvair 440[211] |
| Sunbird Airlines | North Carolina | | ED | SBD | SUNBIRD | Charlotte Douglas | 1979 | 1987 | Absorbed byAtlanta Express. BecameCCAir in 1986.[212] |
| Sunbird Airlines | Tennessee | | | | | Nashville | 1980 | 1980 | OperatedPiper Cherokee Six[213] |
| Sunbird Airways | Florida | | B6 | | | Orlando | 1993 | 1996 | [214] |
| SunCoast Airlines | Florida | | WS | SNT | SUNCOAST | Fort Lauderdale-Hollywood | 1986 | 1988 | Went bankrupt. OperatedBoeing 727-100 |
| Sunjet Aviation | Florida | | | | | Orlando Sanford | 1997 | 1999 | OperatedCessna Citation V,Learjet 35[215] |
| Sunrise Airlines | Nevada | | OQ | SDC | SUNDANCE | Las Vegas McCarran | 1967 | 2000 | Established asLake Powell Air Service[216] |
| Sunwest International | |  | | | | | | | |
| Sunworld International Airlines | Kentucky |  | SM | SWI | SUNWORLD | Cincinnati/Northern Kentucky | 1996 | 2004 | |
| Sunworld International Airways | Nevada |  | JK | SWI | SUNWORLD | Las Vegas McCarran | 1983 | 1988 | Established asJetwest International Airways |
| Supair | California | | | | | Buchanan Field | 1950 | 1953 | OperatedDC-3[217] |
| Superior Air | West Virginia | | | | | Fairmont | 1972 | 1973 | OperatedBN Islander[218] |
| Superior Airlines | Georgia | | | | | Atlanta | 1960 | 1963 | Operatedde Havilland Dove,Aero Commander[219] |
| Superior Airlines | Indiana | | | | | | 1961 | 1962 | |
| Superior Airlines | Arizona | | | | | Columbus Glenn | 1994 | 2003 | ToMesa Airlines |
| Susquehanna Airways | New York | | | | | Sidney | 1979 | 1985 | Established asForde-Aire. OperatedRiley Turbo Skyliner,Piper Aztec[220] |
| Swift Air | Florida |  | WQ | SWQ | SWIFTFLIGHT | Miami | 1997 | 2019 | Renamed toiAero Airways |
| Swift Aire Lines | California |  | WI | | | San Luis Obispo | 1969 | 1981 | Merged withGolden Gate Airlines |
| Swissjets | Florida | | | | | Fort Lauderdale | 2000 | 2001 | Renamed toTourjets[221] |
| T |
| T & G Aviation | Arizona | | | | | Buckeye | 1990 | 2000 | Renamed toInternational Air Response. OperatedDouglas DC-6,Douglas DC-7B[222] |
| TAB Express Airlines | Florida | | | TBI | TAB | Melbourne Orlando | 1992 | 2005 | OperatedBeech 1900[223] |
| TAG Airlines | Michigan |  | | | | Detroit City | 1955 | 1970 | Shut down following crash |
| TAT-Maddux Air Lines | | | | | | | 1929 | 1930 | Merged withWestern Air Express to form Transcontinental & Western Air |
| Tahoe Air | California |  | XP | CXP | CASINO EXPRESS | Lake Tahoe | 1999 | 1999 | |
| Taku Glacier Air Gold | Alaska | | | | | Juneau | 1984 | 1994 | OperatedCessna Stationair,DHC Beaver[224] |
| Talkeetna Air Service | Alaska | | | | | Talkeetna | 1947 | 1948 | Renamed toTalkeetna Air Taxi[225] |
| Tamgass Aviation | Alaska | | | | | | 1964 | 1969 | Renamed toSouthcoast Airways[226] |
| Tanana Air Taxi | Alaska | | | | | Tanana | 1972 | 1974 | Renamed toAlaska Central Airways[227] |
| Tanner Airlines | California | | | | | Los Angeles | 1930s | 1930s | OperatedStinson Detroiter[5] |
| TapJets | North Dakota | | | | | Fargo Hector | 2016 | 2018 | [228] |
| Taquan Air Service | Alaska | | | | | Ketchikan | 1977 | 2000 | Renamed toTaquan Air. OperatedDHC Beaver[229] |
| Tar Heel Aviation | North Dakota | | | THC | TARHEEL | Jacksonville Ellis | 1975 | 2000 | [230] |
| Tatonduk Flying Service | Alaska | | | | | Eagle | 1977 | 1980 | Renamed toEverts Air Alaska. OperatedCessna 180[231] |
| Taxi Air Group | Ohio | | | | | Cleveland Burke Lakefront | 1955 | 1957 | Founded by William Knight. Renamed toTAG Airlines. OperatedDHC Otter[232] |
| Ted | Illinois |  | UA | UAL | UNITED | Denver | 2004 | 2009 | Merged back into parent companyUnited Airlines |
| Tejas Airlines | Texas | | TB | | | San Antonio | 1976 | 1980 | Filed for Chapter 11 bankruptcy[233] |
| Telair International | |  | | | | | | | |
| Telford Aviation | Maine | | | | | | 1995 | 2004 | [234] |
| Tempelhof Airways | Florida |  | | TEH | TEMPELHOF | Fort Lauderdale | 1981 | 1990 | Operated fromWest Berlin |
| Temple Airlines | |  | | | | | 1968 | 1968 | [235] |
| Tempus Jets | South Carolina | | | | | Greenville–Spartanburg | 2007 | 2018 | Executive jet charter. Went bankrupt[236] |
| TEMSCO Airlines | Alaska | | | | | Ketchikan | 1986 | 1991 | The helicopter division continue to operate asTEMSCO Helicopters Inc.[237] |
| Tennessee Airways | Tennessee | | ZN | TEN | TENNESSEE | Knoxville McGhee | 1978 | 1990 | OperatedEmbraer Bandeirante[238] |
| TennesseeSkies | Tennessee | | | | | Nashville | 2009 | 2012 | APacific Wings subsidiary |
| Tepper Aviation | Florida |  | | | | Crestview | 1987 | 2006 | [239] |
| Texas International Airlines | Texas |  | TI | TIA | TEXAS | Houston Intercontinental DFW Airport | 1969 | 1982 | Merged intoContinental Airlines |
| Texas National Airlines | Texas | | | TXN | TEXAS NATIONAL | San Antonio | 1986 | 1988 | Established asBorder Airlines[240] |
| Texas Air Leasing Corporation | Texas | | | | | | 1984 | 1990 | Aircraft leasing firm[241] |
| The Air-Oasis Co | California | | | | | Long Beach | 1963 | 1963 | OperatedDC-3[242] |
| The Gulf Coast Airline | Louisiana | | | | | New Orleans | 1923 | 1932 | Renamed toJohnson Airways[243] |
| The Hagerstown Commuter | Maryland | | | | | Hagerstown | 1962 | 1983 | Operated as anAllegheny Commuter[244] |
| The Hawaii Express | Hawaii |  | LP | HEA | | Los Angeles | 1982 | 1983 | |
| The Lord's Airline | Florida |  | 5Q | | | Miami | 1986 | 1987 | |
| The Maui Commuter | Hawaii | | | | | Kahului | 1975 | 1978 | Founded by Jack Holzman and Robert Frost. Established asAnanda Air[245] |
| Thompson Aeronautical Corporation | Ohio | | | | | Cleveland | 1928 | 1932 | Renamed toTransamerican Airlines[5] |
| Thor Solberg Aviation | New York | | | | | Curtiss Field | 1929 | 1930 | OperatedGreat Lakes 2-T-1,Bellanca CH-200[246] |
| Thunderbird Airlines | Utah | | | | | Ogden-Hinckley | 1964 | 1969 | Renamed toKey Airlines. OperatedTwin Otter[247] |
| Tibben Flight Lines | Iowa | | | | | Cedar Rapids | 1992 | 1996 | Charter operator[248] |
| TMA Trans-Michigan Airlines | Michigan | | | | | Traverse City | 1969 | 1972 | Cargo carrier[249] |
| TMC Airlines | Michigan | | | TMM | WILLOW RUN | Willow Run | 1994 | 2005 | Cargo carrier. OperatedL-188,DC-8[250] |
| Tol Air | Puerto Rico | | TI | TOL | TOL AIR | | 1983 | 2006 | Acquired byFour Star Air Cargo |
| Tourjets | Florida | | | | | Fort Lauderdale | 2001 | 2002 | Established asSwissjets[251] |
| Tower Air | New York |  | FF | TOW | TEE AIR | New York Kennedy | 1983 | 2000 | |
| TPA-The Aloha Airline | Hawaii |  | | | | Honolulu | 1950 | 1958 | Established asTrans-Pacific Airlines[252] |
| TPI International Airways | Georgia |  | UF | | | Brunswick Golden Isles | 1989 | 1996 | [253] |
| Tradewinds Airlines | North Carolina |  | WI | TDX | TRADEWINDS EXPRESS | Piedmont Triad | 1991 | 2010 | |
| Trans Air | Florida | | GO | TRA | TRANS ISLAND | Fort Lauderdale–Hollywood | 1982 | 1986 | Established asTrans Island Airways[254] |
| Trans Air Lines | Louisiana | | | | | New Orleans Armstrong | 1962 | 1963 | Renamed toAir Lines. OperatedAero Commanders[255] |
| Trans Air Link | Florida | | | | | Miami | 1986 | 1989 | [256] |
| Trans Alaskan Airlines | Alaska | | | | | Anchorage | 1955 | 1963 | OperatedDC-4,DC-6A,PBY-5A Catalina[257] |
| Trans American Airways | California | | | | | Lockheed Air Terminal | 1946 | 1957 | Founded by Edward Ware Tabor. Member airline ofNorth American Airlines Group |
| Trans American Charter | Illinois |  | | ECQ | | Chicago O'Hare | 1992 | 1995 | [258] |
| Trans Caribbean Airways | New York |  | TR | TCA | | | 1945 | 1971 | Acquired byAmerican Airlines |
| Trans Caribbean Air Cargo Lines | New York | | TR | TCA | | | 1945 | 1971 | Original name ofTrans Caribbean Airways |
| Trans Continental Airlines | Michigan |  | TD | TCN | TRANSCOM | Willow Run | 1974 | 1992 | Established asInternational Airlines Academy. Rebranded asExpress.Net Airlines |
| Trans East Airlines | New Hampshire | | | | | Manchester–Boston | 1963 | 1972 | Formed asStatewide Airlines |
| Trans East International | New York | | | | | Farmingdale | 1982 | 1984 | Established asNew York Air. Renamed toIsland Air. OperatedTwin Otter,Embraer Bandeirante[259] |
| Trans Global Airlines | California | | | | | Long Beach | 1957 | 1961 | Founded byDonald Rich[260] |
| Trans Global Airlines | New Jersey | | | | | Newark Liberty | 1979 | 1984 | Charter carrier[261] |
| Trans Global Vacations | |  | | | | | 2002 | 2003 | [262] |
| Trans International Airlines | California |  | TV | TV | TRANS INTERNATIONAL | Oakland | 1960 | 1979 | Supplemental air carrier, formed in 1946 asLos Angeles Air Service, rebranded toTransamerica Airlines in 1979 |
| Trans International Airlines | Florida |  | LP | | | Orlando | 1985 | 1989 | reconstitutedCentral American International |
| Trans International Express | |  | | BAP | BIG APPLE | | 1998 | 2002 | [263] |
| Trans Island Airways | Florida | | GO | TRA | TRANS ISLAND | Fort Lauderdale–Hollywood | 1977 | 1982 | Sold and renamed toTrans Air[264] |
| Trans Magic Airlines | Idaho | | | | | Boise | 1969 | 1974 | Merged intoAir Idaho[265] |
| Trans National Airlines | | | | | | | 1948 | 1957 | Originally Alaska Southern Airlines. Member airline ofNorth American Airlines Group |
| Trans National Airlines (1973) | California | | | | | Oakland | 1973 | 1979 | [266] |
| Trans Ocean Airways | Florida | | | | | Arcadia | 1989 | 1990 | Established asGulf Air International[267] |
| Trans Penn Airlines | Pennsylvania | | | | | Reedsville | 1971 | 1980 | OperatedPiper Navajo[268] |
| Trans Regional Airlines | Texas | | | | | Big Spring | 1975 | 1977 | Founded byLouis Rosembaum. Established asEl Paso Transport[269] |
| Trans Sierra Airlines | Arizona | | | TSI | | Tucson | 1970 | 1971 | Founded by Chris Condon and Allan Silliphant. Renamed toSierra Pacific Airlines[270] |
| Trans Southern Airways | South Carolina | | | | | Florence | 1976 | 1985 | Established asPee Dee Air Express Inc.[271] |
| Trans Southern Aieways | Georgia | | | | | | 1984 | 1985 | Routes that had been dropped byPiedmont Airlines[272] |
| Trans States Airlines | Missouri |  | AX | LOF | WATERSKI | Chicago–O'Hare Denver | 1989 | 2020 | Shutdown due to travel disruptions caused by theCOVID-19 pandemic |
| Trans Tropic Airlines | Florida | | | | | Miami | | | |
| Trans World Airlines | Missouri |  | TW | TWA | TWA | New York Kennedy | 1950 | 2001 | Merged intoAmerican Airlines |
| Trans World Connection | | | New York Kennedy Los Angeles | | |
| Trans World Express |  | RZ | Philadelphia Northeast | 1987 | 1995 | |
| Trans-Air-Link | Florida |  | | GJB | SKY TRUCK | Opa Locka | 1977 | ? | |
| Trans-Cal Airlines | California | | | | | Long Beach | 1968 | 1971 | OperatedBeech Queen Air,Beech Bonanza[273] |
| Trans-Central Airlines | Oklahoma |  | ZM | ACN | | Oklahoma City | 1980 | 1984 | [274] |
| Trans-Colorado Airlines | Colorado | | VJ | TCE | TRANS COLORADO | Gunnison–Crested Butte | 1980 | 1988 | Became aContinental Express carrier |
| Trans-Florida Airlines | Florida | | | TFA | TRANS FLORIDA | Daytona Beach | 1966 | 2006 | Established asDaytona Aviation in 1962[275] |
| Trans-Marine Airways | New York | | | | | Daytona Beach | 1945 | 1946 | Charter services[276] |
| Trans-Michigan Airlines | Michigan | | | | | Traverse City | 1969 | 1970 | OperatedBeech 99,Cherokee Six[277] |
| Trans-Mo Airlines | Missouri | | XU | | | | 1966 | 1986 | |
| Trans-Nebraska Airlines | Nebraska | | | | | | 1971 | 1973 | Founded by Tom Brown. OperatedCessna 402A[278] |
| Trans-Nevada Air Service | Nevada | | | | | Las Vegas McCarran | 1968 | 1971 | Commuter services. OperatedBeech C-45 Expeditor[279] |
| Trans-Pacific Airlines | Hawaii | | | | | Honolulu | 1946 | 1950 | Renamed toTPA-The Aloha Airline. OperatedC-47[280] |
| Trans-Texas Airways | Texas |  | TT | | | Houston-Hobby Dallas-Love Field | 1947 | 1968 | Renamed toTexas International Airlines. OperatedDC-3,Convair 240[281] |
| Transair | New York | | | | | New York-LaGuardia | 1946 | 1946 | [282] |
| Transair Airlines | Florida | | | | | St. Pete–Clearwater | 1946 | 1949 | OperatedDC-3,DC-4,Lockheed Super Electra,Lockheed Lodestar[283] |
| Transair Cargo | Florida | | | | | Miami | 1972 | 1977 | Established asSkyways International in 1962[284] |
| Transair Hawaii | Hawaii | | | | | Honolulu | 1946 | 1948 | OperatedC-46[5] |
| Transamerica Airlines | California |  | TV | TVA | TRANS-AMERICA | Oakland | 1979 | 1986 | Rebranded fromTrans International Airlines |
| Transcontinental & Western Air | New York | | | | | New York-LaGuardia | 1930 | 1950 | Renamed to Trans World Airlines; operatedDC-1,DC-2[285] |
| Transcontinental Air Transport | |  | | | | | 1928 | 1929 | Merged withMaddux Air Lines to form TAT-Maddux Air Lines |
| TransMeridian Airlines | Georgia |  | T9 | TRZ | TRANS MERIDIAN | Orlando Sanford | 1995 | 2005 | Established asPrime Air |
| Transocean Air Lines | California |  | TL | | TALOA | Oakland | 1946 | 1960 | Went bankrupt[286] |
| TransOcean Airways | Louisiana |  | QG | GAT | GULFTRANS | New Iberia | 1989 | 1990 | Established asGulf Air Transport. Charter operator |
| Transtar Airlines | Florida |  | | TRH | TRANSTAR | Orlando | 1992 | 1993 | [287] |
| TranStar Airlines | Texas |  | MC | TST | TRANSTAR | Houston-Hobby | 1986 | 1987 | Shut down by parent companySouthwest Airlines |
| Transtate Airlines | New York | | | | | New York-LaGuardia | 1963 | n/a | OperatedLockheed L-1049[288] |
| Transwest Air Express | California |  | | ACW | | Oakland | 1977 | 1981 | Established asZoom Zoom Air in 1973. Renamed toAir Charter West. OperatedDC-3[289] |
| Transwestern Airlines | Utah |  | WZ | TRW | TRANS WEST | Logan-Cache | 1977 | 1983 | Acquired byHorizon Air |
| Travel Air Aviation | | | | | | | 1969 | 1972 | As part ofAllegheny Commuter. OperatedBeech 99[290] |
| Tri-Motor Safety Airlines | New York | | | | | Garden City | 1929 | 1929 | Rename toNew York Safety Airlines. OperatedFord Trimotor (NC1780)[291] |
| Tri-State Airlines | Iowa | | | | | Rickenbacker | 1930 | 1936 | Renamed toHanford Tri-State Airlines[292] |
| Tri-State Flying Service | West Virginia | | | | | Huntington Tri-State | 1971 | 1972 | Established asAir Enterprises in 1969[293] |
| Tricon International Airlines | Texas | | RI | | | Dallas Love Field | 1967 | 1978 | OperatedBeech 18,DC-3[294] |
| Trinity Air Bahamas | Florida |  | | | | Fort Lauderdale–Hollywood | 1993 | 1993 | [295] |
| TriStar Airlines | Nevada |  | T3 | TRY | TRISTAR AIR | Las Vegas McCarran | 1995 | 1997 | |
| Tropic Air | Hawaii | | | | | Honolulu | 1980 | 1989 | Associated withAir Molokai[296] |
| Tropic Air | California | | | | | Burbank | 1988 | 1988 | [297] |
| Tropical Airways | New York | | | | | New York Kennedy | 1986 | 1989 | [298] |
| Tropics International | Florida | | | | | Miami | 1968 | 1971 | OperatedBeech 18[299] |
| Trump Shuttle | New York |  | TB | TPS | TRUMP | New York-LaGuardia | 1989 | 1992 | ToUS Airways Shuttle |
| Tulip City Executive Express | Minnesota | | | | | Holland | 1995 | 1995 | OperatedBeech 18[300] |
| Tulsa-Oklahoma City Airline | Oklahoma | | | | | Tulsa | 1928 | 1929 | Ownership transferred toUniversal Aviation Corporation[301] |
| Turbo Air | Idaho | | | | | Boise | 1995 | 1995 | Charter carrier[302] |
| Turks Air Cargo | Florida | | | | | Miami | 1972 | 2015 | Founded byRobert Caravan[303] |
| Turner Airlines | Indiana | | | | | Indianapolis | 1947 | 1950 | Renamed toLake Central Airlines[304] |
| TWC Aviation, Inc | California | | | | | San José | 1998 | 2015 | Acquired and rebranded intoLandmark Aviation[305] |
| Twentieth Century Airlines | North Carolina | | | | | Charlotte Douglas | 1946 | 1963 | Founded byGlen Shave andChristopher Bachman. OperatedDC-3,DC-4. A member carrier ofNorth American Airlines |
| Tyee Airlines | Alaska | | OF | | | Ketchikan | 1975 | 1986 | OperatedDHC Beaver[306] |
| Tyme Airlines | Ohio | | | | | Cleveland Burke | 1965 | 1967 | Merged intoWright Airlines[307] |
| U |
| U Fly Air Freighters | Texas | | | | | Dallas Fort Worth | 1973 | 1975 | Cargo operator[308] |
| U. S. Airlines | New York Florida Georgia |  | | | | Fort Lauderdale Atlanta St Peterburg | 1945 | 1954 | Scheduled freight carrier |
| U.S. Aviation | Wyoming | | BH | | | Riverton | 1977 | 1979 | Renamed toAir U.S.[309] |
| UltrAir | New York |  | | ULT | ULTRAIR | New York Kennedy | 1993 | 1994 | [310] |
| UltrAir | Texas | | RL | ULT | | Houston Bush | 1993 | 1994 | Operated727-200[311] |
| Unalakleet Air Taxi | Alaska | | | | | Unalakleet | 1953 | 1979 | Renamed toRyan Air[312] |
| United Couriers | California | | | | | Burbank | 1971 | 1971 | Merged withCalifornia Air Charter[313] |
| United Feeder Service | Illinois | | U2 | UFS | FEEDER EXPRESS | Chicago O'Hare | 1993 | 2000 | [314] |
| United Shuttle | California |  | UA | UAL | UNITED | San Francisco | 1994 | 2001 | Subsidiary ofUnited Airlines, formerly Shuttle by United; folded back into United |
| United States Air Transport | New York | | | | | New York Curtis | 1929 | 1930 | OperatedRyan Brougham[5] |
| United States Overseas Airlines | New Jersey |  | US | US | | Cape May | 1946 | 1964 | Supplemental air carrier, flew scheduled service to Okinawa and military charters |
| United Union Airways | Washington | | | | | Felts Field | 1929 | 1929 | Founded by W R Frentzel, C M Baker & Francis Baker[315] |
| Universal Air Lines Corporation | Missouri |  | | | | St. Louis Lambert | 1928 | 1934 | Merged with 90 other airlines to formAmerican Airlines |
| Universal Airlines | Texas | | | | | El Paso | 1957 | 1959 | dba ofS.S.W. |
| Universal Airlines | Michigan California |  | UV | UV | | Willow Run Oakland | 1966 | 1972 | Established asZantop Air Transport |
| Universal Airlines | Michigan |  | | | | Willow Run | 1979 | 1992 | Cargo operator[316] |
| Universal Aviation Corporation | Missouri | | | | | | 1929 | | An airline holding company |
| Upper Valley Aviation | Texas | | | | | McAllen Miller | 1964 | 1975 | OperatedBeech 99,Beech E18S[317] |
| Uraba, Medellin and Central Airways | Panama Canal Zone | | UR | UR | | N/A | 1932 | 1959 | Owned, equipped and crewed byPan Am |
| U.S. Aircoach | California |  | | | | Hollywood Burbank | 1949 | 1959 | Supplemental air carrier shut byCAB in 1959 for finances & compliance |
| US Airways | Arizona |  | US | USA | US AIR | Phoenix Sky Harbor | 1997 | 2015 | Merged intoAmerican Airlines |
| US Airways Express |  | Phoenix Sky Harbor | Rebranded asAmerican Eagle |
| US Airways Shuttle | Virginia |  | Washington National | Founded asEastern Air Lines Shuttle, rebranded asAmerican Airlines Shuttle |
| US Check Airlines | Ohio | | | | | | 1974 | 1974 | Delivery of documents and small packages[318] |
| US Helicopter | New York | | UH | USH | US HELI | Downtown Manhattan Heliport | 2004 | 2009 | |
| USA3000 Airlines | Pennsylvania |  | US | GWY | GETAWAY | Philadelphia | 2001 | 2012 | |
| USAfrica Airways | Virginia |  | | | | Washington Dulles | 1994 | 1995 | |
| USAir | Arizona |  | | | | Phoenix Sky Harbor | 1979 | 1997 | Renamed toUS Airways |
| Utah Pacific Airways | Utah | | | | | Ogden | 1931 | n/a | [5] |
| Uvalde Aero Service | Texas | | | | | Uvalde | 1965 | 1977 | OperatedLockheed L-12 Electra Junior,Piper Navajo,Piper Twin Comanche[319] |
| V |
| Vagabond Air Travel Club | Ohio | | | | | | 1970 | 1974 | Air travel club. OperatedDC-6B,L-188 Electra[320] |
| Vail Airways | Colorado | | | | | | 1966 | 1968 | Founded byGordon Autry[321] |
| Val-Air Lines | Texas | | | | | Mercedes | 1950 | n/a | Feeder service. OperatedBeech Bonanza,Ryan Navion[5] |
| Valdez Airlines | Alaska | | | | | Anchorage | 1980 | 1984 | Merged withAir North to formLiberty Air[322] |
| Valdosta Phoenix Airlines | Georgia | | | | | Valdosta | 1972 | 1973 | [323] |
| Vale International Airlines | Tennessee | | | VIN | | Nashville | 1979 | 1980 | [324] |
| Valley Airlines | California | | | | | Oakland | 1968 | 1974 | Merged withRam Airways to formPacific Northwest Airways[325] |
| Valley Airlines | Maine | | | | | Fort Kent | 1981 | 1989 | Renamed toNortheast Express[326] |
| Valley Airpark Commuter Service | Colorado | | | | | Denver | 1975 | 1977 | [327] |
| Valley Catalina Airlines | California | | | | | Van Nuys | 1981 | 1981 | [328] |
| Valley Isle Aviation | Hawaii | | | | | Kahului | 1965 | 1967 | [329] |
| ValuJet Airlines | Georgia |  | J7 | VJA | CRITTER | Atlanta | 1993 | 1997 | Merged intoAirTran Airways |
| Vance Air Services | Montana | | | | | Great Falls | 1928 | n/a | Founded byClare Vance. OperatedStinson Detroiter[5] |
| Vance International Airways | Washington |  | | | | Boeing Field | 1960 | 1970 | Briefly known as Charter International Airlines. BecameMcCulloch International Airlines |
| Vanguard Airlines | Missouri |  | NJ | VGD | VANGUARD AIR | Kansas City | 1994 | 2002 | Low cost /low fare airline |
| Varney Air Lines | Idaho |  | | | | Salt Lake City | 1926 | 1934 | Merged intoUnited Airlines |
| Vee Neal Airlines | Pennsylvania | | | | | Latrobe | 1980 | 1983 | renamed toJetstream International Airlines[330] |
| Vercoa Air Service | Illinois | | | | | Danville | 1964 | 1975 | Renamed toBritt Airways[331] |
| Vero Monmouth Airlines | Georgia | | VM | VMA | VERO MAMMOUTH | Vero Beach | 1973 | 1975 | Operatedde Havilland Heron,Martin 4-0-4[332] |
| Veterans Air Lines | New Jersey | | | | | Newark | 1945 | n/a | OperatedDC-3,DC-4[333] |
| Via Airlines | Florida |  | VC | SRY | | Orlando | 2015 | 2019 | Established asCharter Air Transport. OperatedEmbraer Brasilia,Embraer ERJ 145[334] |
| Viair | New Jersey | | | | | Newark | 1935 | 1935 | Charter and resort air service[335] |
| ViaAir | Florida |  | VC | SRY | STINGRAY | Beckley Raleigh County | 1997 | 2019 | Went bankrupt |
| Victory Aviation Services International | New York | | | | | New York-LaGuardia | 1995 | 1999 | [336] |
| Viking Air Lines | California | | | | | Lockheed Air Terminal | 1946 | 1956 | Established asAero-Van Express |
| Viking Air Transport | California | | | | | Glendale, California | 1946 | 1947 | In 1947 became non operating parent company of Aero-Van Express |
| Viking International Airlines | Minnesota | | VO | VIK | VIKING | Minneapolis–Saint Paul | 1969 | 1994 | Acquired byEagle Air International[337] |
| Vintage Airways | Florida |  | | | | Kissimmee | 1992 | 1995 | Founded byRichard Branson operated in 1940s livery[338] |
| Vintage Props and Jets | Florida |  | VQ | VPP | VINTAGE | New Smyrna Beach | 1992 | 2008 | Went bankrupt |
| Virgin America | California |  | VX | VRD | REDWOOD | San Francisco | 2004 | 2018 | Acquired byAlaska Airlines |
| Virgin Islands Seaplane Shuttle | US Virgin Islands | | | VSS | WATERBIRD | Saint Croix | 1982 | 1989 | [339] |
| Virginia Air Cargo | Maryland | | | | | Baltimore–Washington | 1974 | 1979 | OperatedBN islander,Short Skyvan[340] |
| Visco Flying Service | California | | | | | Los Angeles | 1964 | 1967 | Operated shuttle service. Renamed toImperial Airlines[341] |
| Viscount Air Service | Arizona |  | | VCT | VISCOUNT AIR | Tucson | 1992 | 1996 | OperatedBoeing 727,Boeing 737 |
| Vision Airlines | Nevada |  | V2 | RBY | RUBY | North Las Vegas | 1994 | 2017 | Established as Vision Air. Incorporated in Virginia. Revoked by State |
| Volunteer Airlines | Tennessee | | | | | Berry Field | 1954 | 1955 | Tennesseeintrastate airline briefly operated byCapitol Airways |
| VQ Airlines | Florida | | | | | Daytona Beach | 1970 | 1973 | Airline division ofVolusia Aviation Service[342] |
| Vroman Aviation | Texas | | | | | | 1965 | 1972 | Established asChamps Aviation[343] |
| W |
| Walatka Air Service | Alaska | | | | | | 1930 | 1930 | [344] |
| Walker's International | Florida | | XW | WRC | | Fort Lauderdale | 1982 | 2003 | Established asJet Hansa Corporation in 1967[345] |
| Warsaw Aviation | Indiana | | | | | Warsaw | 1971 | 1971 | Third-level services. OperatedPiper Twin Comanche,Piper Apache[346] |
| Waterman Airlines | Alabama | | | | | Mobile | 1946 | 1948 | OperatedLockheed Lodestar,DC-3[347] |
| Washington Airlines | Maryland | | | | | Baltimore–Washington | 1968 | 1969 | STOL operation[348] |
| Washington Flying Service | Virginia | | | | | Washington | 1928 | 1929 | Scenic flights[349] |
| Washington-Baltimore Airways | Maryland | | | | | Baltimore–Washington | 1961 | 1971 | OperatedBeech 18,Piper Apache[350] |
| Watermakers Air | Florida | | | | | Fort Lauderdale | 1999 | 2018 | OperatedCessna Grand Caravan[351] |
| Waterman Airlines | Alabama | | | | | | 1945 | 1947 | Intrastate carrier[352] |
| Watertown Airways | South Dakota | | | | | Watertown | 1935 | 1936 | [5] |
| Webber Airlines | Alaska | | | | | Ketchikan Harbor Seaplane Base | 1970 | 1979 | Founded by Jim Webber. Merged withFlair Air to formSoutheast Alaska Airlines. OperatedDHC Beaver],Grumman Goose[353] |
| Wedekind-Schmidlapp Flying Service | Ohio | | | | | Hook Field | 1932 | 1961 | Founded byLarry Schmidlapp andGeorge "Pappy" Wedekind. OperatedWaco VKS-7[354] |
| Wedell-Williams Air Service Corporation | Louisiana | | | | | Patterson | 1929 | 1936 | Founded byJimmy Wedell andHarry Palmerston Williams. Acquired byEastern Air Lines. OperatedLockheed Vega 5B[355] |
| Wes-Tex Aircraft | Texas | | | | | Lubbock Airport | 1964 | 1971 | OperatedPiper Navajo,Piper Twin Comanche,Piper Cherokee[356] |
| West Central Airlines | Nebraska | | | | | Omaha | 1966 | 1971 | Operatedde Havilland Dove,Cherokee Six,Cessna 182[357] |
| West Coast Air Cargo | Oregon | | | WCC | WEST COAST | Portland–Troutdale | 1982 | 1999 | Cargo carrier[358] |
| West Coast Airlines | Washington |  | WC | | | Seattle–Tacoma | 1941 | 1968 | Merged withPacific Air Lines andBonanza Air Lines to formAir West which was then renamedHughes Airwest in 1970 |
| WestAir Airlines | California | | | | | Fresno Yosemite | 1978 | 1986 | Established asStol Air Commuter. Renamed toWestAir Commuter Airlines[359] |
| WestAir Commuter Airlines | California |  | OE | SDU | SUNDANCE | Fresno Yosemite | 1978 | 1992 | FormerlyStol Air Commuter, toMesa Air Group |
| Westair Transport | |  | | | | Seattle | 1947 | 1960 | Supplemental air carrier stopped flying in 1960 afterIRS seized assets, adba of Aviation Corp. of Seattle |
| Westates Airlines | California New Jersey | | WS | WSA | WESTATES | Los Angeles Atlantic City | 1984 | 1995 | Renamed toGray Line Air[360] |
| Western Air Express | California |  | | | | Los Angeles | 1926 | 1930 | OperatedDouglas M-2,Fokker F-10[361] |
| Western Air Express Texas | Texas | | | | | Midland | 2004 | 2016 | OperatedBeech Queen Air 70[362] |
| Western Air Industries | California | | | | | Redding | 1960 | 1960 | Aerial firefighting carrier. Renamed toAero Union. OperatedB-25 Mitchell[363] |
| Western Air Service | Nebraska | | | | | Eppley Airfield | 1930 | 1930 | OperatedFord Trimotor[5] |
| Western Air Stages | Colorado | | | | | Grand Junction | 1972 | 1976 | OperatedBeech Queen Air,Riley Dove 400[364] |
| Western Aircraft | Idaho | | | | | Gooding | 1964 | 1971 | OperatedBeech 18,Piper Apache[365] |
| Western Aircraft Salvage | California | | | | | Santa Maria | 1974 | 1980 | OperatedBeech 18,Piper Apache[366] |
| Western Airlines | California |  | WA | WAL | WESTERN | Los Angeles | 1941 | 1987 | Merged intoDelta Air Lines |
| Western Airlines (2007) | Washington | | XP | CXP | RUBY MOUNTAIN | Bellingham | 2007 | 2007 | |
| Western Alaska Airlines | Alaska | | | | | Kodiak | 1940 | 1973 | Merged withKodiak Airways to formKodiak Western Alaska[367] |
| Western Express Air | Arizona | | | | | Laughlin/Bullhead | | 2007 | |
| Western Pacific Airlines | Colorado |  | W7 | KMR | KOMSTAR | Colorado Springs | 1995 | 1998 | |
| Westflight Aviation | Alaska | | | | | Ketchikan | 1981 | 1986 | Acquired byTemsco Airlines[368] |
| WestJet Express | Nevada | | | | | Fresno Yosemite | 1998 | 1999 | Renamed toAllegiant Air[369] |
| Westward Airways | Nebraska | | CN | WWD | WESTWARD | Western Nebraska | 2004 | 2005 | |
| Wheeler Airlines | North Carolina | | | | | Raleigh–Durham | 1969 | 1991 | Established asWheeler Flying Service[370] |
| Whidbey Flying Service | Washington | | | | | Oak Harbor | 1964 | 1969 | Founded byWes Luipen. ToPuget Sound Airlines[371] |
| Wien | Alaska |  | | | | Anchorage | 1982 | 1984 | [372] |
| Wien Air Alaska |  | WC | WAA | | 1973 | 1982 | Several name changes over the years, final nameWien[373] |
| Wien Airways of Alaska |  | | | | 1926 | 1935 | Established asNorthern Air Transport[374] |
| Wien Alaska Airways |  | | | | 1935 | 1968 | Merged withNorthern Consolidated Airlines to formWien Consolidated Airlines[375] |
| Wien Consolidated Airlines | | | | | 1968 | 1973 | Formed by the merger ofWien Alaska Airlines andNorthern Consolidated Airlines[376] |
| Wilbur's Inc. | Alaska | | | | | Anchorage | 1984 | 1992 | [377] |
| Wild Goose Flying Service | Texas | | | | | San Antonio | 1984 | 1992 | [378] |
| Wildblue Yonder-Aero Taxi | Idaho | | | | | Lemhi County | 1998 | 1998 | [379] |
| Williams Air | New Jersey | | | | | | 1981 | 1983 | OperatedBN Islander[380] |
| Wilmington-Catalina Airline | California |  | | | | Hamilton Cove Seaplane Base | 1931 | 1942 | Certificated by theCivil Aeronautics Board in 1939, owned by theWrigley family. |
| WinAir Airlines | Utah |  | | WNA | WINAIR | Salt Lake City | 1997 | 1999 | |
| Winged Cargo Company | Pennsylvania | | | | | Northeast Philadelphia | 1931 | 1946 | Freight service. OperatedDC-3 towingWaco CG-4[381] |
| Wings Air | Georgia | | | WAI | | Atlanta | 2008 | 2010 | [382] |
| Wings Airways | Pennsylvania | | WQ | WAW | WING SHUTTLE | Blue Bell Wings Field | 1977 | 1991 | |
| Wings Express | California | | | | | Burbank | 1993 | 1993 | Cargo carrier. Acquired byAmeriflight[383] |
| Wings of Alaska | Alaska | | K5 | SQH | SASQUACH | Juneau | 1982 | 2017 | Founded by Dean Williams and Billy Bernhardt. Established asSoutheast Skyways. OperatedCessna 207,DHC-3 Otter |
| Wings West Airlines | California |  | RM | WWM | WINGS WEST | McChesney Field | 1979 | 1998 | Later operated asAmerican Eagle, then merged intoSimmons Airlines |
| Winkys Fish Airlines | Alaska | | | | | Anchorage | 1990 | 1990 | OperatedBoeing 727. Salmon transport[384] |
| Winnipesaukee Airlines | Florida | | | | | Tampa | 1976 | 1977 | [385] |
| Wisconsin Central Airlines | Wisconsin |  | | | | Clintonville | 1946 | 1952 | Renamed toNorth Central Airlines[386] |
| Wise Airlines | Texas | | 4W | | | San Angelo | 1983 | 1985 | OperatedBeech 99,Twin Otter. Went bankrupt[387] |
| Woodley Airways | Alaska | | | | | Merrill Field | 1932 | 1945 | Renamed toPacific Northern Airlines[388] |
| Woods Air Service | Alaska | | | | | Palmer | 1961 | 2000 | [389] |
| World Airways | Georgia |  | WO | WOA | WORLD | Atlanta | 1948 | 2014 | |
| World American Airlift | California | | | | | Fresno Yosemite | 1968 | 1970 | [390] |
| World Wide Airlines | Alaska | | | | | Anchorage | 1956 | 1962 | Established asPearson-Alaska Airlines in 1948. OperatedDC-4,C-46,L-749,L-1049[391] |
| Worldwide Airlines | Illinois | | | | | Chicago Midway | 1983 | 1986 | Subsidiary ofCarefree Vacations Inc.[392] |
| Wrangler Aviation | North Carolina | | | | | Piedmont Triad | 1973 | 1991 | Established asBluebell Aviation in 1969. Renamed toTradewinds Airlines[393] |
| Wright Airlines | Ohio |  | FW | WRT | WRIGHT | Cleveland Burke | 1966 | 1983 | Went bankrupt |
| WTC Air Freight | New Jersey | | | | | | 1967 | 1987 | Acquired byBAX Global[394] |
| Wyoming Air Service | Wyoming | | | | | Cheyenne | 1930 | 1937 | Renamed toInland Air Lines. OperatedStinson Junior,Boeing 247D[395] |
| Wyoming-Montana Air Lines | Wyoming | | | | | Casper–Natrona | 1930 | 1938 | Renamed toInland Air Lines in 1938[396] |
| X |
| Xtra Airways | Florida |  | XP | CXP | CASINO EXPRESS | Houston-Hobby | 1987 | 2021 | Founded asCasino Express Airlines commenced operations in 1989. Rebranded asAvelo Airlines. |
| Y |
| Yankee Airlines | Massachusetts | | | | | Pittsfield | 1962 | 1968 | Acquired by Executive Airlines. Operatedde Havilland Dove[397] |
| Yosemite Airlines | California | | JE | | | Columbia | 1975 | 1981 | [398] |
| Your Florida Air | | | | | | | 2005 | 2005 | never launched[399] |
| Yukon Air Service | Alaska | | | | | Fairbanks | 1967 | 1973 | Founded by Roger Dowding. Renamed to Air North[400] |
| Yutana Airlines | Alaska | | | | | Anchorage | 1987 | 1994 | Renamed toAlaska Central Express[401] |
| Yute Air | Alaska | | 4Y | UYA | | Bethel | 2004 | 2017 | [402] |
| Yute Air Alaska | Alaska | | | | | Bethel | 1974 | 2000 | Established asBob Harris Flying Service. Renamed toFlight Alaska[403] |
| Z |
| Zantop Air Transport | Michigan |  | | | | Willow Run | 1956 | 1966 | Took over the certificate of Coastal Air Lines in 1962. ToUniversal Airlines |
| Zantop Airways | Michigan | | | JTZ | JETZAN | Detroit | 1968 | 1981 | Part 298 operator that becameOrion Air |
| Zantop Flying Service | Michigan | | | | | Willow Run | 1946 | 1956 | BecameZantop Air Transport |
| Zantop International Airlines | Michigan |  | VK | ZAN | ZANTOP | Willow Run | 1972 | 2005 | |
| Zetta Jet | California |  | | | | Burbank | 2015 | 2017 | Established asAdvanced Air Management[404] |
| Zia Airlines | New Mexico | | | | | Las Cruces | 1972 | 1980 | Renamed toAir New Mexico.Air ambulance services[405] |
| Zimmerly Air Lines | Idaho | | | | | Boise | 1942 | 1946 | RenamedEmpire Airlines[406] |
| Zoom Zoom Air | California | | | | | Oakland | 1973 | 1974 | Renamed fromArabesco Air[407] Renamed toAir Charter West. OperatedBasler BT-67[408] |