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TYRO3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

TYRO3

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1RHF

Identifiers

Aliases

TYRO3, BYK, Dtk, RSE, Sky, Tif, Etk-2, Rek, TYRO3 protein tyrosine kinase

External IDs

OMIM:600341;MGI:104294;HomoloGene:4585;GeneCards:TYRO3;OMA:TYRO3 - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q15.1	Start	41,557,675bp^[1]
Band	15q15.1	End	41,583,589bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 E5\|2 59.97 cM	Start	119,628,214bp^[2]
Band	2 E5\|2 59.97 cM	End	119,648,585bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

frontal pole

Brodmann area 10

paraflocculus of cerebellum

middle frontal gyrus

right hemisphere of cerebellum

right frontal lobe

Brodmann area 9

cerebellar vermis

C1 segment

cingulate gyrus

Top expressed in

primary motor cortex

perirhinal cortex

olfactory epithelium

piriform cortex

olfactory tubercle

superior frontal gyrus

entorhinal cortex

cingulate gyrus

prefrontal cortex

primary visual cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity virus receptor activity kinase activity phosphatidylinositol 3-kinase binding protein binding protein heterodimerization activity ATP binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor tyrosine kinase transmembrane signaling receptor activity Wnt-protein binding
Cellular component	integral component of membrane nuclear envelope endoplasmic reticulum membrane membrane plasma membrane integral component of plasma membrane nucleus cell surface cytoplasm receptor complex
Biological process	vagina development phosphorylation negative regulation of lymphocyte activation protein phosphorylation viral entry into host cell phosphatidylinositol 3-kinase signaling protein autophosphorylation viral process signal transduction natural killer cell differentiation cell adhesion negative regulation of innate immune response spermatogenesis platelet activation forebrain cell migration apoptotic cell clearance substrate adhesion-dependent cell spreading peptidyl-tyrosine phosphorylation ovulation cycle negative regulation of neuron apoptotic process platelet aggregation neuron cellular homeostasis protein kinase B signaling negative regulation of toll-like receptor signaling pathway secretion by cell negative regulation of inflammatory response neuropeptide signaling pathway negative regulation of signal transduction Wnt signaling pathway cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7301


22174

Ensembl


ENSG00000092445


ENSMUSG00000027298

UniProt


Q06418


P55144

RefSeq (mRNA)


NM_006293 NM_001330264


NM_001290800 NM_019392

RefSeq (protein)


NP_001317193 NP_006284


NP_001277729 NP_062265

Location (UCSC)

Chr 15: 41.56 – 41.58 Mb

Chr 2: 119.63 – 119.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tyrosine-protein kinase receptor TYRO3 is anenzyme that in humans is encoded by theTYRO3gene.^[5]^[6]

Interactions

[edit]

TYRO3 has been shown tointeract with:

GAS6,^[7]^[8] and
PIK3R1^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000092445 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000027298 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (March 1995). "Regional localization of human chromosome 15 loci".Genomics.23 (3):619–27.doi:10.1006/geno.1994.1550.PMID 7851890.
^"Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase".
^Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996)."Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl".J. Biol. Chem.271 (16):9785–9.doi:10.1074/jbc.271.16.9785.PMID 8621659.
^Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (November 1996)."Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases".J. Biol. Chem.271 (47):30022–7.doi:10.1074/jbc.271.47.30022.PMID 8939948.
^Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (January 2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway".Blood.95 (2):633–8.doi:10.1182/blood.V95.2.633.PMID 10627473.

Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ (1994)."rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain".J. Biol. Chem.269 (14):10720–8.doi:10.1016/S0021-9258(17)34118-2.PMID 7511603.
Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase".Biochem. Biophys. Res. Commun.209 (2):656–63.Bibcode:1995BBRC..209..656T.doi:10.1006/bbrc.1995.1549.PMID 7537495.
Crosier KE, Hall LR, Lewis PM, Morris CM, Wood CR, Morris JC, Crosier PS (1995). "Isolation and characterization of the human DTK receptor tyrosine kinase".Growth Factors.11 (2):137–44.doi:10.3109/08977199409001055.PMID 7857658.
Ohashi K, Mizuno K, Kuma K, Miyata T, Nakamura T (1994). "Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain".Oncogene.9 (3):699–705.PMID 8108112.
Dai W, Pan H, Hassanain H, Gupta SL, Murphy MJ (1994). "Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis".Oncogene.9 (3):975–9.PMID 8108143.
Polvi A, Armstrong E, Lai C, Lemke G, Huebner K, Spritz RA, Guida LC, Nicholls RD, Alitalo K (1994). "The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25".Gene.134 (2):289–93.doi:10.1016/0378-1119(93)90109-G.PMID 8262388.
Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (1996)."Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl".J. Biol. Chem.271 (16):9785–9.doi:10.1074/jbc.271.16.9785.PMID 8621659.
Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis".Exp. Hematol.24 (2):318–23.PMID 8641360.
Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K (1997)."Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases".J. Biol. Chem.271 (47):30022–7.doi:10.1074/jbc.271.47.30022.PMID 8939948.
Kajii Y, Ninomiya D, Kato M, Mizuguchi M, Saji M, Katsumoto T, Ohno K, Takashima S, Onodera K (1997). "A tyrosine kinase-like molecule is localized in the nuclear membrane of neurons: hippocampal behavior under stress".Biol. Cell.88 (1–2):45–54.doi:10.1016/S0248-4900(97)86830-X.PMID 9175267.S2CID 31494402.
Lan Z, Wu H, Li W, Wu S, Lu L, Xu M, Dai W (2000). "Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway".Blood.95 (2):633–8.doi:10.1182/blood.V95.2.633.PMID 10627473.
Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM (2004). "Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts".Transpl. Int.16 (9):681–8.doi:10.1007/s00147-003-0593-3 (inactive 20 October 2025).PMID 12768229.S2CID 13419387.{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)
Heiring C, Dahlbäck B, Muller YA (2004)."Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family".J. Biol. Chem.279 (8):6952–8.doi:10.1074/jbc.M311750200.PMID 14623883.
Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA (2005)."Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses".J. Thromb. Haemost.3 (4):733–41.doi:10.1111/j.1538-7836.2005.01186.x.PMID 15733062.
Hafizi S, Gustafsson A, Stenhoff J, Dahlbäck B (2005). "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases".Int. J. Biochem. Cell Biol.37 (11):2344–56.doi:10.1016/j.biocel.2005.05.006.PMID 15964779.
Shimojima M, Takada A, Ebihara H, Neumann G, Fujioka K, Irimura T, Jones S, Feldmann H, Kawaoka Y (2006)."Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses".J. Virol.80 (20):10109–16.doi:10.1128/JVI.01157-06.PMC 1617303.PMID 17005688.

v t e PDB gallery
1rhf: Crystal Structure of human Tyro3-D1D2

Protein kinases:tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR ERBB2 ERBB3 ERBB4
Insulin receptor family	IGF1R INSR INSRR
PDGF receptor family	CSF1R FLT3 KIT PDGFR (PDGFRA PDGFRB)
FGF receptor family	FGFR1 FGFR2 FGFR3 FGFR4
VEGF receptors family	VEGFR1 VEGFR2 VEGFR3
HGF receptor family	MET RON
Trk receptor family	NTRK1 NTRK2 NTRK3

EPH receptor family

LTK receptor family

TIE receptor family

ROR receptor family

DDR receptor family

PTK7 receptor family

PTK7

RYK receptor family

MuSK receptor family

MUSK

ROS receptor family

ROS1

AATYK receptor family

AXL receptor family

RET receptor family

uncategorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 ARG
ACK family	ACK1 TNK1
CSK family	CSK MATK
FAK family	FAK PYK2
FES family	FES FER
FRK family	FRK BRK SRMS
JAK family	JAK1 JAK2 JAK3 TYK2
SRC-A family	SRC FGR FYN YES1
SRC-B family	BLK HCK LCK LYN
TEC family	TEC BMX BTK ITK TXK
SYK family	SYK ZAP70

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