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TRPV3-74a

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Chemical compound

Pharmaceutical compound

TRPV3-74a
Identifiers

IUPAC name 3-[(S)-hydroxy(pyridin-2-yl)methyl]-1-methyl-3-[4-(trifluoromethyl)pyridin-2-yl]cyclobutan-1-ol
CAS Number	1432051-63-2
PubChemCID	71554840
ChemSpider	58922619
ChEMBL	ChEMBL3828340
Chemical and physical data
Formula	C₁₇H₁₇F₃N₂O₂
Molar mass	338.330 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O
InChI InChI=1S/C17H17F3N2O2/c1-15(24)9-16(10-15,14(23)12-4-2-3-6-21-12)13-8-11(5-7-22-13)17(18,19)20/h2-8,14,23-24H,9-10H2,1H3/t14-,15?,16?/m1/s1 Key:MTJXDHFAWXGXIN-QQFBHYJXSA-N

TRPV3-74a is a drug which acts as a selectiveantagonist for theTRPV3 calcium channel. It hasanalgesic effects in animal studies against bothneuropathic pain and normalpain responses.^[1]^[2]

^Gomtsyan A, Schmidt RG, Bayburt EK, Gfesser GA, Voight EA, Daanen JF, et al. (May 2016). "Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists".Journal of Medicinal Chemistry.59 (10):4926–47.doi:10.1021/acs.jmedchem.6b00287.PMID 27077528.
^Kocienski P (February 2017). "Synthesis of a TRPV3 Antagonist".Synfacts.13 (2): 123.doi:10.1055/s-0036-1589889.S2CID 100058677.

Activators

Blockers

Activators	Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P
Blockers	DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid

Activators	ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10 Eucalyptol (eucalyptus) Frescolat MGA Frescolat ML Geraniol Hydroxycitronellal Icilin Linalool Menthol (mint) PMD 38 Pregnenolone sulfate Rutamarin (Ruta graveolens) Steviol glycosides (e.g.,stevioside) (Stevia rebaudiana) Sweettastants (e.g.,glucose,fructose,sucrose; indirectly) Thio-BCTC WS-12
Blockers	AMG-333 Capsazepine Clotrimazole DCDPC Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5