TrpC5 is one of the seven mammalianTRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly withTRPC1,TRPC3, andTRPC4. It also interacts with multiple proteins includingcalmodulin,CABP1,enkurin, Na+–H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), andSEC14 domain and spectrin repeat-containing protein 1 (SESTD1).[5]
TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity[8] and neurological behavior.[9] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.[10]
Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reducedthioredoxin.[11] This channel has also been found to be involved in the action of anaesthetics such aschloroform,halothane andpropofol.[12]
^Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, et al. (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel".Genomics.60 (3):330–340.doi:10.1006/geno.1999.5924.PMID10493832.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels".Pharmacological Reviews.57 (4):427–450.doi:10.1124/pr.57.4.6.PMID16382100.S2CID17936350.
^Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology".Nature Neuroscience.6 (8):837–845.doi:10.1038/nn1092.PMID12858178.S2CID7523946.
Beech DJ (February 2007). "Bipolar phospholipid sensing by TRPC5 calcium channel".Biochemical Society Transactions.35 (Pt 1):101–104.doi:10.1042/BST0350101.PMID17233612.
