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TOX2

From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
TOX high mobility group box family member 2
Identifiers
SymbolTOX2
Alt. symbolsC20orf100, GCX-1
NCBI gene84969
HGNC16095
OMIM611163
RefSeqNM_001098796
UniProtQ96NM4
Other data
LocusChr. 20q13.12
Search for
StructuresSwiss-model
DomainsInterPro

TOX high mobility group box family member 2, also known asTOX2, is a humangene.[1][2]

Theprotein encoded by this gene is a member of a subfamily oftranscription factors that also includesTOX,TOX3, andTOX4 that share almost identicalHMG-boxDNA-binding domains which function to modifychromatin structure.[3]

References

[edit]
  1. ^"Entrez Gene: TOX high mobility group box family member 2".
  2. ^Kajitani T, Mizutani T, Yamada K, Yazawa T, Sekiguchi T, Yoshino M, Kawata H, Miyamoto K (May 2004). "Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells".Endocrinology.145 (5):2307–18.doi:10.1210/en.2003-1343.PMID 14764631.S2CID 25037508.
  3. ^O'Flaherty E, Kaye J (April 2003)."TOX defines a conserved subfamily of HMG-box proteins".BMC Genomics.4 (1) 13.doi:10.1186/1471-2164-4-13.PMC 155677.PMID 12697058.
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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