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TM-38837

From Wikipedia, the free encyclopedia
Chemical compound
This articlemay rely excessively on sourcestoo closely associated with the subject, potentially preventing the article from beingverifiable andneutral. Please helpimprove it by replacing them with more appropriatecitations toreliable, independent sources.(April 2011) (Learn how and when to remove this message)
Pharmaceutical compound
TM-38837
Clinical data
ATC code
  • none
Identifiers
  • 1-(2,4-Dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC30H25Cl2F3N4OS
Molar mass617.51 g·mol−1
3D model (JSmol)
  • O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CC)NN5CCCCC5
  • InChI=1S/C30H25Cl2F3N4OS/c1-2-23-27(29(40)37-38-16-4-3-5-17-38)36-39(25-14-11-21(31)18-24(25)32)28(23)26-15-13-22(41-26)12-8-19-6-9-20(10-7-19)30(33,34)35/h6-7,9-11,13-15,18H,2-5,16-17H2,1H3,(H,37,40)
  • Key:VQOCBFYUDSBDCZ-UHFFFAOYSA-N

TM-38837 is a small moleculeinverse agonist/antagonist of theCB1 cannabinoid receptor, with peripheral selectivity. It is being developed for the treatment ofobesity and metabolic disorders by 7TM Pharma.[1] The company has announcedphase I clinical trials.

TM-38837 is among the first of a new generation ofcannabinoid receptor antagonist designed to avoid thecentral nervous system liabilities of the first generation CB1 receptor antagonists such asrimonabant.[2]

See also

[edit]

References

[edit]
  1. ^"7TM Pharma". Archived fromthe original on July 7, 2011. RetrievedJanuary 18, 2011.
  2. ^Hung MS, Chang CP, Li TC, Yeh TK, Song JS, Lin Y, et al. (September 2010)."Discovery of 1-(2,4-dichlorophenyl)-4-ethyl-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophen-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide as a potential peripheral cannabinoid-1 receptor inverse agonist".ChemMedChem.5 (9):1439–43.doi:10.1002/cmdc.201000246.PMID 20652930.S2CID 34244587.

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