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TLX1

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Protein coding gene in Humans

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TLX1

Identifiers

Aliases

TLX1, HOX11, TCL3, T-cell leukemia homeobox 1, T cell leukemia homeobox 1

External IDs

OMIM:186770;MGI:98769;HomoloGene:4031;GeneCards:TLX1;OMA:TLX1 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q24.31	Start	101,131,300bp^[1]
Band	10q24.31	End	101,137,789bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19 C3\|19 38.45 cM	Start	45,139,119bp^[2]
Band	19 C3\|19 38.45 cM	End	45,145,382bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

spleen

testicle

minor salivary glands

gonad

right lobe of liver

mucosa of transverse colon

duodenum

tonsil

ventricle of the heart

left ventricle

Top expressed in

dorsal mesentery

tongue

middle ear

submandibular gland

outer ear

auricle

skin of external ear

female urethra

male urethra

Eustachian tube

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity
Cellular component	nucleus
Biological process	multicellular organism development regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


3195


21908

Ensembl


ENSG00000107807


ENSMUSG00000025215

UniProt


P31314


P43345

RefSeq (mRNA)


NM_001195517 NM_005521


NM_021901

RefSeq (protein)


NP_001182446 NP_005512


n/a

Location (UCSC)

Chr 10: 101.13 – 101.14 Mb

Chr 19: 45.14 – 45.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

T-cell leukemia homeobox protein 1 is aprotein that in humans is encoded by theTLX1gene, which was initially namedHOX11.^[5]^[6]^[7]^[8]^[9]

Interactions

[edit]

TLX1 has been shown tointeract withPPP1CC,^[10]PPP2CB^[10] andPPP2CA.^[10]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000107807 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025215 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia".Science.253 (5015):79–82.Bibcode:1991Sci...253...79H.doi:10.1126/science.1676542.PMID 1676542.
^McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes".Genomics.7 (3): 460.doi:10.1016/0888-7543(90)90186-X.PMID 1973146.
^"Entrez Gene: TLX1 T-cell leukemia homeobox 1".
^Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991)."HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24".Proceedings of the National Academy of Sciences of the United States of America.88 (20):8900–4.Bibcode:1991PNAS...88.8900K.doi:10.1073/pnas.88.20.8900.PMC 52618.PMID 1681546.
^Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991)."A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)".Blood.78 (11):2996–3003.doi:10.1182/blood.V78.11.2996.2996.PMID 1683261.
^^a ^b ^cKawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint".Nature.385 (6615):454–8.Bibcode:1997Natur.385..454K.doi:10.1038/385454a0.PMID 9009195.S2CID 608633.

Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia".Leukemia & Lymphoma.39 (3–4):241–56.doi:10.3109/10428190009065824.PMID 11342305.S2CID 27407074.
Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells".Oncogene.7 (7):1325–30.PMID 1352396.
Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991)."HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24".Proceedings of the National Academy of Sciences of the United States of America.88 (20):8900–4.Bibcode:1991PNAS...88.8900K.doi:10.1073/pnas.88.20.8900.PMC 52618.PMID 1681546.
Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991)."The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein".The EMBO Journal.10 (10):2905–10.doi:10.1002/j.1460-2075.1991.tb07840.x.PMC 453003.PMID 1717256.
Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development".Development.121 (9):2909–15.doi:10.1242/dev.121.9.2909.PMID 7555717.
Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993)."The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes".Proceedings of the National Academy of Sciences of the United States of America.90 (10):4431–5.Bibcode:1993PNAS...90.4431D.doi:10.1073/pnas.90.10.4431.PMC 46525.PMID 8099440.
Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint".Nature.385 (6615):454–8.Bibcode:1997Natur.385..454K.doi:10.1038/385454a0.PMID 9009195.S2CID 608633.
Brake RL, Kees UR, Watt PM (Oct 1998)."Multiple negative elements contribute to repression of the HOX11 proto-oncogene".Oncogene.17 (14):1787–95.doi:10.1038/sj.onc.1202078.PMID 9778044.
Zhang N, Shen W, Hawley RG, Lu M (Apr 1999)."HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization".Oncogene.18 (13):2273–9.doi:10.1038/sj.onc.1202545.PMID 10327073.
Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line".Gene.234 (1):169–76.doi:10.1016/S0378-1119(99)00157-2.PMID 10393251.
Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11".Biochemical and Biophysical Research Communications.294 (1):23–34.doi:10.1016/S0006-291X(02)00426-6.PMID 12054735.
Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function".DNA Sequence.13 (2):77–83.doi:10.1080/10425170290029981.PMID 12180349.S2CID 38713800.
Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004)."Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951".Blood.103 (2):442–50.doi:10.1182/blood-2003-05-1495.PMID 14504110.
Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11".Genes, Chromosomes & Cancer.41 (4):309–20.doi:10.1002/gcc.20104.PMID 15384172.S2CID 19475690.
Riz I, Hawley RG (Aug 2005)."G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia".Oncogene.24 (36):5561–75.doi:10.1038/sj.onc.1208727.PMC 2408753.PMID 15897879.
Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006)."The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells".Leukemia.20 (2):304–12.doi:10.1038/sj.leu.2404071.PMID 16357834.
Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006)."Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice".Oncogene.25 (18):2575–87.doi:10.1038/sj.onc.1209285.PMID 16407851.

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

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