Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Transporter Classification Database

From Wikipedia, the free encyclopedia
(Redirected fromTCDB)
Classification of membrane proteins including ion channels

TheTransporter Classification Database (orTCDB) is anInternational Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system formembrane transport proteins, includingion channels.[1][2][3]

Classification

[edit]

The upper level of classification and a few examples of proteins with known 3D structure:

1.Channels and pores

[edit]

1.A α-type channels

[edit]

1.B.β-Barrel porins and other outer membrane proteins

[edit]

1.CPore-forming toxins (proteins and peptides)

[edit]

1.D Non-ribosomally synthesized channels

[edit]
  • 1.D.1 TheGramicidin A Channel Family
  • 1.D.2 The Channel-formingSyringomycin Family
  • 1.D.3 The Channel-Forming Syringopeptin Family
  • 1.D.4 The Tolaasin Channel-forming Family
  • 1.D.5 TheAlamethicin orPeptaibol Antibiotic Channel-forming Family
  • 1.D.6 The Complexed Poly 3-Hydroxybutyrate Ca2+ Channel (cPHB-CC) Family
  • 1.D.7 The Beticolin Family
  • 1.D.8 TheSaponin Family
  • 1.D.9 ThePolyglutamine Ion Channel (PG-IC) Family
  • 1.D.10 TheCeramide-forming Channel Family
  • 1.D.11 TheSurfactin Family
  • 1.D.12 The Beauvericin (Beauvericin) Family
  • 1.D.13 DNA-delivery Amphipathic Peptide Antibiotics (DAPA)
  • 1.D.14 The Synthetic Leu/Ser Amphipathic Channel-forming Peptide (l/S-SCP) Family
  • 1.D.15The Daptomycin (Daptomycin) Family
  • 1.D.16 The Synthetic Amphipathic Pore-forming Heptapeptide (SAPH) Family
  • 1.D.17 Combinatorially-designed, Pore-forming, β-sheet Peptide Family
  • 1.D.18 The Pore-forming Guanosine-Bile Acid Conjugate Family
  • 1.D.19 Ca2+ Channel-forming Drug,Digitoxin Family
  • 1.D.20 The Pore-forming Polyene Macrolide Antibiotic/fungal Agent (PMAA) Family
  • 1.D.21 The Lipid Nanopore (LipNP) Family
  • 1.D.22 The Proton-Translocating Carotenoid Pigment,Zeaxanthin Family
  • 1.D.23 Phenylene Ethynylene Pore-forming Antimicrobial (PEPA) Family
  • 1.D.24 The Marine Sponge Polytheonamide B (pTB) Family
  • 1.D.25 The Arylamine Foldamer (AAF) Family
  • 1.D.26 The Dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucoside (DDDC9G) Family
  • 1.D.27 The Thiourea isosteres Family
  • 1.D.28 The Lipopeptaibol Family
  • 1.D.29 The Macrocyclic Oligocholate Family
  • 1.D.30 The Artificial Hydrazide-appended pillar[5]arene Channels (HAPA-C) Family
  • 1.D.31 TheAmphotericin B Family
  • 1.D.32 The Pore-formingNovicidin Family
  • 1.D.33 The Channel-formingPolytheonamide B Family
  • 1.D.34 The Channel-forming Oligoester Bolaamphiphiles
  • 1.D.35 The Pore-forming cyclicLipodepsipeptide Family
  • 1.D.36 TheOligobornene Ion Channel Family
  • 1.D.37 TheHibicuslide C Family
  • 1.D.38 The Cyclic Peptide Nanotube (cPepNT) Family
  • 1.D.39 The Light-controlled Azobenzene-based Amphiphilic Molecular Ion Channel (AAM-IC) Family
  • 1.D.40 The Protein-induced Lipid Toroidal Pore Family
  • 1.D.41 The Sprotetonate-type Ionophore (Spirohexanolide) Family
  • 1.D.42 The Phe-Arg Tripeptide-Pillar[5]Arene Channel (TPPA-C) Family
  • 1.D.43 The Triazole-tailored Guanosine Dinucleoside Channel (TT-GDN-C) Family
  • 1.D.44 The Synthetic Ion Channel with Redox-active Ferrocene (ICRF) Family
  • 1.D.45 The Sonoporation and Electroporation Membrane Pore (SEMP) Family
  • 1.D.46 The DNA Nanopore (DnaNP) Family
  • 1.D.47 The Pore-forming Synthetic Cyclic Peptide (PSCP) Family
  • 1.D.48 The Pore-formingSyringomycin E Family
  • 1.D.49 The Transmembrane Carotenoid Radical Channel (CRC) Family
  • 1.D.50 The Amphiphilic bis-Catechol Anion Transporter (AC-AT) Family
  • 1.D.51 The Protein Nanopore (ProNP) Family
  • 1.D.52 The Aromatic Oligoamide Macrocycle Nanopore (OmnNP) Family
  • 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT) Family
  • 1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5-Ether Ion Channel (HBEC) Family
  • 1.D.55 The Porphyrin-based Nanopore (PorNP) Family
  • 1.D.56 The Alpha-Aminoisobutyrate (Aib) Oligomeric Nanopore (AibNP) Family
  • 1.D.57 The Lipid Electro-Pore (LEP) Family
  • 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family
  • 1.D.59 The Anion Transporting Perenosin (Perenosin) Family
  • 1.D.60 The Alpha,Gamma-Cyclic Peptide (AGCP) Family
  • 1.D.61 The Anionophoric 2,6-Bis(Benzimidazol-2-yl)Pyridine (ABBP) Family
  • 1.D.62 The Bis-Triazolyl DiGuanosine Derivative Channel-forming (TDG) Family
  • 1.D.63 The Peptide-based Nanopore (PepNP) Family
  • 1.D.64 The Carbon Nanotube (CarNT) Family
  • 1.D.65 The Pore-forming Amphidinol (Amphidinol) Family
  • 1.D.66 The Helical Macromolecule Nanopore (HmmNP) Family
  • 1.D.67 The Crown Ether-modified Helical Peptide Ion Channel (CEHP) Family
  • 1.D.68 The Pore-forming Pleuronic Block Polymer (PPBP) Family
  • 1.D.69 The Conical Nanopore (ConNP) Family
  • 1.D.70 The Metallic (Au/Ag/Pt/graphene) Nanopore (MetNP) Family
  • 1.D.71 The Synthetic TP359 Peptide (TP359) Family
  • 1.D.72 The Chloride Carrier Triazine-based Tripodal Receptor (CCTTR) Family
  • 1.D.73 The Mesoporous Silica Nanopore (SilNP) Family
  • 1.D.74 The Stimulus-responsive Synthetic Rigid p-Octiphenyl Stave Pore (SSROP) Family

1.EHolins

[edit]
Main article:Holins

1.FVesicle fusion pores

[edit]
  • 1.F.1 The Synaptosomal Vesicle Fusion Pore (SVF-Pore) Family
  • 1.F.2 The Octameric Exocyst (Exocyst) Family

1.GViral fusion pores

[edit]
  • 1.G.1 The Viral Pore-forming Membrane Fusion Protein-1 (VMFP1) Family
  • 1.G.2 The Viral Pore-forming Membrane Fusion Protein-2 (VMFP2) Family
  • 1.G.3 The Viral Pore-forming Membrane Fusion Protein-3 (VMFP3) Family
  • 1.G.4 The Viral Pore-forming Membrane Fusion Protein-4 (VMFP4) Family
  • 1.G.5 The Viral Pore-forming Membrane Fusion Protein-5 (VMFP5) Family
  • 1.G.6 The Hepadnaviral S Fusion Protein (HBV-S Protein) Family
  • 1.G.7 The Reovirus FAST Fusion Protein (R-FAST) Family
  • 1.G.8 The Arenavirus Fusion Protein (AV-FP) Family
  • 1.G.9 The Syncytin (Syncytin) Family
  • 1.G.10 The Herpes Simplex Virus Membrane Fusion Complex (HSV-MFC) Family
  • 1.G.11 Poxvirus Cell Entry Protein Complex (PEP-C) Family
  • 1.G.12 The Avian Leukosis Virus gp95 Fusion Protein (ALV-gp95) Family
  • 1.G.13 The Orthoreovirus Fusion-associated Small Transmembrane (FAST) Family
  • 1.G.14 The Influenza Virus Hemagglutinin/Fusion Pore-forming Protein (Influenza-H/FPP) Family
  • 1.G.15 The Autographa californica Nuclear Polyhedrosis Virus Major Envelope Glycoprotein GP64 (GP64) Family
  • 1.G.16 The Human Immunodeficiency Virus Type 1 (HIV-1) Fusion Peptide (HIV-FP) Family
  • 1.G.17 The Bovine Leukemia Virus Envelop Glycoprotein (BLV-Env) Family
  • 1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family
  • 1.G.19 The Rotavirus Pore-forming Membrane Fusion Complex (Rotavirus MFC) Family
  • 1.G.20 The Hantavirus Gc Envelope Fusion Glycoprotein (Gc-EFG) Family
  • 1.G.21 The Epstein Barr Virus (Human Herpes Virus 4) Gp42 (Gp42) Family
  • 1.G.22 The Cytomegalovirus (Human Herpesvirus 5) Glycoprotein gO (gO) Family

1.HParacellular channels

[edit]
  • 1.H.1 TheClaudin Tight Junction (Claudin1) Family
  • 1.H.2 The Invertebrate PMP22-Claudin (Claudin2) Family

1.IMembrane-bound channels

[edit]

2. Electrochemical potential-driven transporters

[edit]

2.A Porters (uniporters,symporters,antiporters)

[edit]
See also:Amino acid transporter
  • 2.A.1Major Facilitator superfamily (MFS), see alsoLactose permease,Phosphate permease andGlucose transporter
  • 2.A.2The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family
  • 2.A.3The Amino Acid-Polyamine-Organocation (APC) Family
  • 2.A.4Cation diffusion facilitator (CDF) Family
  • 2.A.5Zinc (Zn2+)-Iron (Fe2+) Permease Family
  • 2.A.6Resistance-Nodulation-Cell Division Superfamily, see alsoSecDF protein-export membrane protein
  • 2.A.7 TheDrug/Metabolite Transporter (DMT) Superfamily
  • 2.A.8 The Gluconate:H+ Symporter (GntP) Family
  • 2.A.9 The Membrane Protein Insertase (YidC/Alb3/Oxa1) Family
  • 2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family
  • 2.A.11 The Citrate-Mg2+:H+ (CitM) Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family
  • 2.A.12ATP:ADP Antiporter Family
  • 2.A.13 The C4-Dicarboxylate Uptake (Dcu) Family
  • 2.A.14Lactate Permease Family
  • 2.A.15The Betaine/Carnitine/Choline Transporter (BCCT) Family
  • 2.A.16Tellurite-resistance/Dicarboxylate Transporter Family
  • 2.A.17Proton-dependent Oligopeptide Transporter Family
  • 2.A.18 The Amino Acid/Auxin Permease (AAAP) Family
  • 2.A.19 The Ca2+:Cation Antiporter (CaCA) Family
  • 2.A.20 The Inorganic Phosphate Transporter (PiT) Family
  • 2.A.21Solute:Sodium Symporter Family
  • 2.A.22 TheNeurotransmitter:Sodium Symporter Family
  • 2.A.23 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
  • 2.A.24 The 2-Hydroxycarboxylate Transporter (2-HCT) Family
  • 2.A.25Alanine or Glycine:Cation Symporter (AGCS) Family
  • 2.A.26 The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
  • 2.A.27 The Glutamate:Na+ Symporter (ESS) Family
  • 2.A.28Bile Acid:Na+ Symporter Family
  • 2.A.29Mitochondrial carrier Family
  • 2.A.30Cation-Chloride Cotransporter (CCC) Family
  • 2.A.31Anion Exchanger Family
  • 2.A.32 The Silicon Transporter (Sit) Family
  • 2.A.33NhaA Na+:H+ Antiporter (NhaA) Family
  • 2.A.34 The NhaB Na+:H+ Antiporter (NhaB) Family
  • 2.A.35 The NhaC Na+:H+ Antiporter (NhaC) Family
  • 2.A.36Monovalent Cation:Proton Antiporter-1 (CPA1) Family
  • 2.A.37Monovalent Cation:Proton Antiporter-2 (CPA2) Family
  • 2.A.38K+ Transporter (Trk) Family
  • 2.A.39Nucleobase:Cation Symporter-1 (NCS1) Family
  • 2.A.40Nucleobase:Cation Symporter-2 (NCS2) Family
  • 2.A.41 The Concentrative Nucleoside Transporter (CNT) Family
  • 2.A.42 The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
  • 2.A.43 The Lysosomal Cystine Transporter (LCT) Family
  • 2.A.45Arsenite-Antimonite Efflux Family
  • 2.A.46 The Benzoate:H+ Symporter (BenE) Family
  • 2.A.47Divalent Anion:Na+ Symporter (DASS) Family
  • 2.A.48 The Reduced Folate Carrier (RFC) Family
  • 2.A.49Chloride Carrier/Channel (ClC) Family
  • 2.A.50 The Glycerol Uptake (GUP) Family
  • 2.A.51 The Chromate Ion Transporter (CHR) Family
  • 2.A.52 The Ni2+-Co2+ Transporter (NiCoT) Family
  • 2.A.53Sulfate permease (SulP) Family
  • 2.A.54 The Mitochondrial Tricarboxylate Carrier (MTC) Family
  • 2.A.55The Metal Ion (Mn2+-iron) Transporter (Nramp) Family
  • 2.A.56 The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family
  • 2.A.57 The Equilibrative Nucleoside Transporter (ENT) Family
  • 2.A.58 The Phosphate:Na+ Symporter (PNaS) Family
  • 2.A.59 The Arsenical Resistance-3 (ACR3) Family
  • 2.A.60Organo Anion Transporter (OAT) Family
  • 2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family
  • 2.A.62 The NhaD Na+:H+ Antiporter (NhaD) Family
  • 2.A.63The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family
  • 2.A.64Twin Arginine Targeting (Tat) Family
  • 2.A.65 The Bilirubin Transporter (BRT) Family
  • 2.A.66 The Multidrug/Oligosaccharidyl-lipid/Polysaccharide (MOP) Flippase Superfamily
  • 2.A.67 The Oligopeptide Transporter (OPT) Family
  • 2.A.68 The p-Aminobenzoyl-glutamate Transporter (AbgT) Family
  • 2.A.69 The Auxin Efflux Carrier (AEC) Family
  • 2.A.70 The Malonate:Na+ Symporter (MSS) Family
  • 2.A.71 The Folate-Biopterin Transporter (FBT) Family
  • 2.A.72 The K+ Uptake Permease (KUP) Family
  • 2.A.73 The Short Chain Fatty Acid Uptake (AtoE) Family
  • 2.A.74 The 4 TMS Multidrug Endosomal Transporter (MET) Family
  • 2.A.75 The L-Lysine Exporter (LysE) Family
  • 2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family
  • 2.A.77 The Cadmium Resistance (CadD) Family
  • 2.A.78 The Branched Chain Amino Acid Exporter (LIV-E) Family
  • 2.A.79 The Threonine/Serine Exporter (ThrE) Family
  • 2.A.80 The Tricarboxylate Transporter (TTT) Family
  • 2.A.81 The Aspartate:Alanine Exchanger (AAEx) Family
  • 2.A.82 The Organic Solute Transporter (OST) Family
  • 2.A.83 The Na+-dependent Bicarbonate Transporter (SBT) Family
  • 2.A.84 The Chloroplast Maltose Exporter (MEX) Family
  • 2.A.85 The Aromatic Acid Exporter (ArAE) Family
  • 2.A.86 The Autoinducer-2 Exporter (AI-2E) Family (Formerly the PerM Family, TC #9.B.22)
  • 2.A.87 The Prokaryotic Riboflavin Transporter (P-RFT) Family
  • 2.A.88 Vitamin Uptake Transporter (VUT or ECF) Family
  • 2.A.89 The Vacuolar Iron Transporter (VIT) Family
  • 2.A.90Vitamin A Receptor/Transporter (STRA6) Family
  • 2.A.91 Mitochondrial tRNA Import Complex (M-RIC) (Formerly 9.C.8)
  • 2.A.92 The Choline Transporter-like (CTL) Family
  • 2.A.94 The Phosphate Permease (Pho1) Family
  • 2.A.95 The 6TMS Neutral Amino Acid Transporter (NAAT) Family
  • 2.A.96 The Acetate Uptake Transporter (AceTr) Family
  • 2.A.97 The Mitochondrial Inner Membrane K+/H+ and Ca2+/H+ Exchanger (LetM1) Family
  • 2.A.98 The Putative Sulfate Exporter (PSE) Family
  • 2.A.99 The 6TMS Ni2+ uptake transporter (HupE-UreJ) Family
  • 2.A.100 The Ferroportin (Fpn) Family
  • 2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1)
  • 2.A.102 The 4-Toluene Sulfonate Uptake Permease (TSUP) Family
  • 2.A.103 The Bacterial Murein Precursor Exporter (MPE) Family
  • 2.A.104 The L-Alanine Exporter (AlaE) Family
  • 2.A.105 The Mitochondrial Pyruvate Carrier (MPC) Family
  • 2.A.106 The Ca2+:H+ Antiporter-2 (CaCA2) Family
  • 2.A.107 The MntP Mn2+ Exporter (MntP) Family
  • 2.A.108 The Iron/Lead Transporter (ILT) Family
  • 2.A.109 The Tellurium Ion Resistance (TerC) Family
  • 2.A.110 The Heme Transporter, heme-responsive gene protein (HRG) Family
  • 2.A.111 The Na+/H+ Antiporter-E (NhaE) Family
  • 2.A.112 The KX Blood-group Antigen (KXA) Family
  • 2.A.113 The Nickel/cobalt Transporter (NicO) Family
  • 2.A.114 The Putative Peptide Transporter Carbon Starvation CstA (CstA) Family
  • 2.A.115 The Novobiocin Exporter (NbcE) Family
  • 2.A.116 The Peptidoglycolipid Addressing Protein (GAP) Family
  • 2.A.117 The Chlorhexadine Exporter (CHX) family
  • 2.A.118 The Basic Amino Acid Antiporter (ArcD) Family
  • 2.A.119 The Organo-Arsenical Exporter (ArsP) Family
  • 2.A.120 The Putative Amino Acid Permease (PAAP) Family
  • 2.A.121 The Sulfate Transporter (CysZ) Family
  • 2.A.122 The LrgB/CidB holin-like auxiliary protein (LrgB/CidB) Family
  • 2.A.123 The Sweet; PQ-loop; Saliva; MtN3 (Sweet) Family
  • 2.A.124 The Lysine Exporter (LysO) Family
  • 2.A.125 The Eukaryotic Riboflavin Transporter (E-RFT) Family
  • 2.A.126 The Fatty Acid Exporter (FAX) Family
  • 2.A.127 Enterobacterial Cardiolipin Transporter (CLT) Family

2.B Nonribosomally synthesized porters

[edit]
  • 2.B.1 TheValinomycin Carrier Family
  • 2.B.2 TheMonensin Family
  • 2.B.3 TheNigericin Family
  • 2.B.4 TheMacrotetrolide Antibiotic (MA) Family
  • 2.B.5 The Macrocyclic Polyether (MP) Family
  • 2.B.6 TheIonomycin Family
  • 2.B.7 The Transmembrane α-helical Peptide Phospholipid Translocation (TMP-PLT) Family
  • 2.B.8 TheBafilomycin A1 (Bafilomycin) Family
  • 2.B.9 TheCell Penetrating Peptide (CPP) Functional Family
  • 2.B.10 The Synthetic CPP,Transportan Family
  • 2.B.11 TheCalcimycin or A23187 Carrier-type Ionophore Family
  • 2.B.12 TheSalinomycin Family
  • 2.B.13 The Tetrapyrrolic Macrocyclic Anion Antiporter (TPMC-AA) Family
  • 2.B.14 The Lasalocid A or X-537A Ionophore (Lasalocid) Family
  • 2.B.15 The Tris-thiourea Tripodal-based Chloride Carrier (TTT-CC) Family
  • 2.B.16 The Halogen-bond-containing Compound Anion Carrier (HCAC) Family
  • 2.B.17 The Isophthalaminde Derivative H+:Cl Co-transporter (IDC) Family
  • 2.B.18 The Pyridine-2,6-Dicarboxamine Derivative (PDCA) H+:Cl Co-transporter Family
  • 2.B.19 The Calix(4)pyrrole Derivative (C4P) Family
  • 2.B.20 The Prodigiosin (Prodigiosin) Chloride/Bicarbonate Exchanger Family
  • 2.B.21 The ortho-Phenylenediamine-bis-Urea Derivative Anion Transporter (oPDA-U) Family
  • 2.B.22 The Imidazolium-functionalized Anion Transporter (IAT) Family
  • 2.B.23 The Homotetrameric Transmembrane Zn2+/Co2+:Proton Synthetic Antiporter, Rocker (Rocker) Family
  • 2.B.24 The 2,6-Bis(benzimidazol-2-yl)pyridine Anion Carrier (BBP-AC) Family
  • 2.B.25 The Peptide-mediated Lipid Flip-Flop (PLFF) Family
  • 2.B.26 The Bis(imidazolyl)-functionalized Bis(Choloyl) Conjugate (BIBCC) Family
  • 2.B.27 The Tris-Urea Anion Transporter Family
  • 2.B.29 The Anionophoric Marine AlkaloidTambjamine Family

2.C Ion-gradient-driven energizers

[edit]
  • 2.C.1 The TonB-ExbB-ExbD/TolA-TolQ-TolR (TonB) Family of Auxiliary Proteins for Energization of Outer Membrane Receptor (OMR)-mediated Active Transport

3.Primary active transporters

[edit]

3.A. P-P-bond hydrolysis-driven transporters

[edit]
  • 3.A.1ABC transporters including BtuCD, molybdate uptake transporter,Cystic fibrosis transmembrane conductance regulator and others
  • 3.A.2 The H+- or Na+-translocatingF-type ATPase,V-type ATPase and A-type ATPase superfamily
  • 3.A.3The P-type ATPase Superfamily
  • 3.A.4The Arsenite-Antimonite efflux family
  • 3.A.5General secretory pathway (Sec)translocon (preprotein translocase SecY)
  • 3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family
  • 3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
  • 3.A.8 The Mitochondrial Protein Translocase (MPT) Family
  • 3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family
  • 3.A.10H+, Na+-translocating Pyrophosphatase family
  • 3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family
  • 3.A.12 The Septal DNA Translocator (S-DNA-T) Family
  • 3.A.13 The Filamentous Phage Exporter (FPhE) Family
  • 3.A.14 The Fimbrilin/Protein Exporter (FPE) Family
  • 3.A.15 The Outer Membrane Protein Secreting Main Terminal Branch (MTB) Family
  • 3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family
  • 3.A.17 The Phage T7 Injectisome (T7 Injectisome) Family
  • 3.A.18 The Nuclear mRNA Exporter (mRNA-E) Family
  • 3.A.19 The TMS Recognition/Insertion Complex (TRC) Family
  • 3.A.20 The Peroxisomal Protein Importer (PPI) Family
  • 3.A.21 The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family
  • 3.A.22 The Transcription-coupled TREX/TAP Nuclear mRNA Export Complex (TREX) Family
  • 3.A.23 The Type VI Symbiosis/Virulence Secretory Pathway (VISP) Family
  • 3.A.24 Type VII or ESX Protein Secretion System (T7SS) Family
  • 3.A.25 The Symbiont-specific ERAD-like Machinery (SELMA) Family
  • 3.A.26 The Plasmodium Translocon of Exported proteins (PTEX) Family

3.B Decarboxylation-driven transporters

[edit]
  • 3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family

3.C Methyltransfer-driven transporters

[edit]
  • 3.C.1 The Na+ Transporting Methyltetrahydromethanopterin:Coenzyme M Methyltransferase (NaT-MMM) Family

3.D. Oxidoreduction-driven transporters

[edit]

They include a number of transmembranecytochrome b-like proteins includingcoenzyme Q - cytochrome c reductase (cytochrome bc1 );cytochrome b6f complex; formate dehydrogenase, respiratorynitrate reductase;succinate - coenzyme Q reductase (fumarate reductase); andsuccinate dehydrogenase. Seeelectron transport chain.

  • 3.D.1The H+ or Na+-translocating NADH Dehydrogenase ("complex I") family
  • 3.D.2 The Proton-translocating Transhydrogenase (PTH) Family
  • 3.D.3The Proton-translocating Quinol:Cytochrome c Reductase) Superfamily
  • 3.D.4Proton-translocating Cytochrome Oxidase (COX) Superfamily
  • 3.D.5 The Na+-translocating NADH:Quinone Dehydrogenase (Na-NDH or NQR) Family
  • 3.D.6 The Putative Ion (H+ or Na+)-translocating NADH:Ferredoxin Oxidoreductase (NFO or RNF) Family
  • 3.D.7 The H2:Heterodisulfide Oxidoreductase (HHO) Family
  • 3.D.8 The Na+- or H+-Pumping Formyl Methanofuran Dehydrogenase (FMF-DH) Family
  • 3.D.9 The H+-translocating F420H2 Dehydrogenase (F420H2DH) Family
  • 3.D.10 The Prokaryotic Succinate Dehydrogenase (SDH) Family

3.E. Light absorption-driven transporters

[edit]

4. Group translocators

[edit]

4.A Phosphotransfer-driven group translocators

[edit]
Main article:PTS-GFL superfamily

4.B Nicotinamide ribonucleoside uptake transporters

[edit]
  • 4.B.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family

4.C Acyl CoA ligase-coupled transporters

[edit]
  • 4.C.1 The Proposed Fatty Acid Transporter (FAT) Family
  • 4.C.2 The Carnitine O-Acyl Transferase (CrAT) Family
  • 4.C.3 The Acyl-CoA Thioesterase (AcoT) Family

4.D Polysaccharide Synthase/Exporters

[edit]
  • 4.D.1 The Putative Vectorial Glycosyl Polymerization (VGP) Family
  • 4.D.2 The Glycosyl Transferase 2 (GT2) Family
  • 4.D.3 The Glycan Glucosyl Transferase (OpgH) Family

4.E. Vacuolar Polyphosphate Polymerase-catalyzed Group Translocators

[edit]
  • 4.E.1 The Vacuolar (Acidocalcisome) Polyphosphate Polymerase (V-PPP) Family

5. Transport electron carriers

[edit]

5.A Transmembrane 2-electron transfer carriers

[edit]
  • 5.A.1 The Disulfide Bond Oxidoreductase D (DsbD) Family
  • 5.A.2 The Disulfide Bond Oxidoreductase B (DsbB) Family
  • 5.A.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO) Family

5.B Transmembrane 1-electron transfer carriers

[edit]
  • 5.B.1 The Phagocyte (gp91phox)NADPH Oxidase Family
  • 5.B.2 The EukaryoticCytochrome b561 (Cytb561) Family
  • 5.B.3 The Geobacter Nanowire Electron Transfer (G-NET) Family
  • 5.B.4 The Plant Photosystem I Supercomplex (PSI) Family
  • 5.B.5 The Extracellular Metal Oxido-Reductase (EMOR) Family
  • 5.B.6 TheTransmembrane Epithelial Antigen Protein-3 Ferric Reductase (STEAP) Family
  • 5.B.7 TheYedZ (YedZ) Family
  • 5.B.8 The Trans-Outer Membrane Electron Transfer Porin/Cytochrome Complex (ET-PCC) Family
  • 5.B.9 The Porin-Cytochrome c (Cyc2) Family

8. Accessory factors involved in transport

[edit]

8.A Auxiliary transport proteins

[edit]

8.B Ribosomally synthesized protein/peptide toxins that target channels and carriers

[edit]

8.C Non-ribosomally synthesized toxins that target channels and carriers

[edit]

9. Incompletely characterized transport systems

[edit]

9.A Recognized transporters of unknown biochemical mechanism

[edit]

9.B Putative transport proteins

[edit]

9.C Functionally characterized transporters lacking identified sequences

[edit]

References

[edit]
  1. ^Saier, Milton H.; Reddy, Vamsee S.; Tamang, Dorjee G.; Västermark, Åke (January 2014)."The Transporter Classification Database".Nucleic Acids Research.42 (D1):D251 –D258.doi:10.1093/nar/gkt1097.PMC 3964967.PMID 24225317.
  2. ^Saier, M. H.; Yen, M. R.; Noto, K.; Tamang, D. G.; Elkan, C. (1 January 2009)."The Transporter Classification Database: recent advances".Nucleic Acids Research.37 (Database):D274 –D278.doi:10.1093/nar/gkn862.PMC 2686586.PMID 19022853.
  3. ^Saier, M. H.; Tran, C. V.; Barabote, R. D. (1 January 2006)."TCDB: the Transporter Classification Database for membrane transport protein analyses and information".Nucleic Acids Research.34 (90001):D181 –D186.doi:10.1093/nar/gkj001.PMC 1334385.PMID 16381841.

External links

[edit]
Ligand-gated
Voltage-gated
Constitutively active
Proton-gated
Voltage-gated
Calcium-activated
Inward-rectifier
Tandem pore domain
Voltage-gated
Miscellaneous
Cl:Chloride channel
H+:Proton channel
M+:CNG cation channel
M+:TRP cation channel
H2O (+solutes):Porin
Cytoplasm:Gap junction
By gating mechanism
Ion channel class
see alsodisorders
Antimicrobial cationic peptides
Other, human
Other, nonhuman
Non-ribosomally synthesized channels (TC 1D)
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPI
COPII
RME/Clathrin
Caveolae
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter,Cotransporter
Antiporter (exchanger)
Nonribosomally synthesized porters (TC 2B)
A
B
C
D
E
F
G
F-, V-, and A-type ATPase (3.A.2)
H+ (F-type)
H+ (V-type)
A-ATPase
found in Archea
P-type ATPase (3.A.3)
Ion pump:proton pumps: Oxidoreduction-driven transporters (TC 3D)
ETC
Other
Retrieved from "https://en.wikipedia.org/w/index.php?title=Transporter_Classification_Database&oldid=1219405657"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp