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TAS2R3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

TAS2R3

Identifiers

Aliases

TAS2R3, T2R3, taste 2 receptor member 3

External IDs

OMIM:604868;MGI:3606604;HomoloGene:23231;GeneCards:TAS2R3;OMA:TAS2R3 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q34	Start	141,764,097bp^[1]
Band	7q34	End	141,765,197bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 B1	Start	40,468,167bp^[2]
Band	6\|6 B1	End	40,469,239bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus callosum

epithelium of colon

Achilles tendon

tonsil

right hemisphere of cerebellum

right uterine tube

urinary bladder

ovary

body of uterus

muscle of thigh

Top expressed in

embryo

primary oocyte

zygote

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity taste receptor activity bitter taste receptor activity
Cellular component	plasma membrane membrane integral component of membrane
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste sensory perception of taste signal transduction response to stimulus G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


50831


574417

Ensembl


ENSG00000127362


ENSMUSG00000052850

UniProt


Q9NYW6


Q7TQA7

RefSeq (mRNA)


NM_016943


NM_001025385

RefSeq (protein)


NP_058639


NP_001020556

Location (UCSC)

Chr 7: 141.76 – 141.77 Mb

Chr 6: 40.47 – 40.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Taste receptor type 2 member 3 is aprotein that in humans is encoded by theTAS2R3gene.^[5]

Function

[edit]

This gene encodes a member of a family of candidatetaste receptors that are members of theG protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.^[5]

Ligands

[edit]

The only known ligand for TAS2R3 inBitterDB ischloroquine.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000127362 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000052850 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: TAS2R3 taste receptor, type 2, member 3".
^"hTAS2R3".BitterDB. The Hebrew University of Jerusalem.

Kinnamon SC (2000)."A plethora of taste receptors".Neuron.25 (3):507–10.doi:10.1016/S0896-6273(00)81054-5.PMID 10774719.
Margolskee RF (2002)."Molecular mechanisms of bitter and sweet taste transduction".J. Biol. Chem.277 (1):1–4.doi:10.1074/jbc.R100054200.PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste".Curr. Opin. Neurobiol.12 (4):366–71.doi:10.1016/S0959-4388(02)00345-8.PMID 12139982.S2CID 37807140.
Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000)."A novel family of mammalian taste receptors".Cell.100 (6):693–702.doi:10.1016/S0092-8674(00)80705-9.PMID 10761934.S2CID 14604586.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000)."T2Rs function as bitter taste receptors".Cell.100 (6):703–11.doi:10.1016/S0092-8674(00)80706-0.PMID 10761935.S2CID 7293493.
Firestein S (2000)."The good taste of genomics".Nature.404 (6778):552–3.doi:10.1038/35007167.PMID 10766221.S2CID 35741332.
Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse".Nature.404 (6778):601–4.Bibcode:2000Natur.404..601M.doi:10.1038/35007072.PMID 10766242.S2CID 4336913.
Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting".Biochem. Biophys. Res. Commun.285 (1):147–51.doi:10.1006/bbrc.2001.5136.PMID 11437385.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003)."Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways".Cell.112 (3):293–301.doi:10.1016/S0092-8674(03)00071-0.PMID 12581520.S2CID 718601.
Fischer A, Gilad Y, Man O, Pääbo S (2005)."Evolution of bitter taste receptors in humans and apes".Mol. Biol. Evol.22 (3):432–6.doi:10.1093/molbev/msi027.PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006)."Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates".Genetics.170 (1):313–26.doi:10.1534/genetics.104.037523.PMC 1449719.PMID 15744053.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)