Transporter associated with antigen processing 1 (TAP1) is aprotein that in humans is encoded by theTAP1gene. A member of theATP-binding cassette transporter family, it is also known as ABCB2.[5][6]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across theendoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated withankylosing spondylitis,insulin-dependent diabetes mellitus, and celiac disease.[7]
TAP1 has been shown tointeract with:
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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