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TAL1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

TAL1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2YPA,2YPB

Identifiers

Aliases

TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor

External IDs

OMIM:187040;MGI:98480;HomoloGene:2400;GeneCards:TAL1;OMA:TAL1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p33	Start	47,216,290bp^[1]
Band	1p33	End	47,232,225bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 D1\|4 52.73 cM	Start	114,913,623bp^[2]
Band	4 D1\|4 52.73 cM	End	114,928,952bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trabecular bone

monocyte

bone marrow

right lung

endothelial cell

blood

upper lobe of left lung

bone marrow cell

buccal mucosa cell

epithelium of colon

Top expressed in

fetal liver hematopoietic progenitor cell

tibiofemoral joint

blood

human fetus

embryo

spleen

endocardial cushion

bone marrow

yolk sac

genital tubercle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein dimerization activity DNA-binding transcription factor activity histone deacetylase binding chromatin binding transcription cis-regulatory region binding E-box binding protein binding protein heterodimerization activity enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	histone deacetylase complex transcription regulator complex Lsd1/2 complex nucleus nucleoplasm protein-containing complex
Biological process	megakaryocyte development megakaryocyte differentiation myeloid cell differentiation cell fate commitment cell differentiation regulation of transcription, DNA-templated regulation of mast cell differentiation spinal cord association neuron differentiation positive regulation of protein-containing complex assembly locomotory behavior positive regulation of erythrocyte differentiation regulation of transcription by RNA polymerase II regulation of stem cell population maintenance platelet formation positive regulation of mitotic cell cycle negative regulation of transcription by RNA polymerase II transcription, DNA-templated generation of neurons basophil differentiation positive regulation of transcription, DNA-templated multicellular organism development regulation of cell population proliferation hematopoietic stem cell differentiation astrocyte fate commitment angiogenesis neuron differentiation embryonic hemopoiesis erythrocyte differentiation definitive hemopoiesis regulation of myeloid cell differentiation positive regulation of cell division hemangioblast cell differentiation positive regulation of transcription by RNA polymerase II erythrocyte maturation regulation of hematopoietic stem cell differentiation hemopoiesis transcription by RNA polymerase II negative regulation of erythrocyte differentiation positive regulation of protein tyrosine kinase activity positive regulation of signaling receptor activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


6886


21349

Ensembl


ENSG00000162367


ENSMUSG00000028717

UniProt


P17542


P22091

RefSeq (mRNA)

NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406
NM_003189


NM_011527 NM_001287388

RefSeq (protein)

NP_001274276 NP_001277332 NP_001277333 NP_001277334 NP_001277335
NP_003180


NP_001274317 NP_035657

Location (UCSC)

Chr 1: 47.22 – 47.23 Mb

Chr 4: 114.91 – 114.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termedstem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is aprotein that in humans is encoded by theTAL1gene.^[5]^[6]

The protein encoded by TAL1 is abasic helix-loop-helix transcription factor.

Interactions

[edit]

TAL1 has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000162367 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000028717 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989)."Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma".Proc Natl Acad Sci U S A.86 (13):5039–43.Bibcode:1989PNAS...86.5039F.doi:10.1073/pnas.86.13.5039.PMC 297552.PMID 2740341.
^"Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
^^a ^b ^c ^d ^eGoardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006)."ETO2 coordinates cellular proliferation and differentiation during erythropoiesis".EMBO J.25 (2):357–66.doi:10.1038/sj.emboj.7600934.PMC 1383517.PMID 16407974.
^Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999)."p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein".Oncogene.18 (35):4958–67.doi:10.1038/sj.onc.1202889.PMID 10490830.
^^a ^bOsada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995)."Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1".Proc. Natl. Acad. Sci. U.S.A.92 (21):9585–9.Bibcode:1995PNAS...92.9585O.doi:10.1073/pnas.92.21.9585.PMC 40846.PMID 7568177.
^^a ^bValge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994)."The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells".Proc. Natl. Acad. Sci. U.S.A.91 (18):8617–21.Bibcode:1994PNAS...91.8617V.doi:10.1073/pnas.91.18.8617.PMC 44657.PMID 8078932.
^^a ^bWadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994)."Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia".EMBO J.13 (20):4831–9.doi:10.1002/j.1460-2075.1994.tb06809.x.PMC 395422.PMID 7957052.
^Huang S, Brandt SJ (March 2000)."mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor".Mol. Cell. Biol.20 (6):2248–59.doi:10.1128/mcb.20.6.2248-2259.2000.PMC 110841.PMID 10688671.
^Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002)."The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1".Blood.100 (7):2430–40.doi:10.1182/blood-2002-02-0568.PMID 12239153.
^Hsu HL, Wadman I, Baer R (April 1994)."Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells".Proc. Natl. Acad. Sci. U.S.A.91 (8):3181–5.Bibcode:1994PNAS...91.3181H.doi:10.1073/pnas.91.8.3181.PMC 43539.PMID 8159721.

External links

[edit]

TAL1+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
FactorBook TAL1

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

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