Trace amine-associated receptor 9 is aprotein that in humans is encoded by theTAAR9gene.[5][6]
TAAR9 is a member of a large family ofrhodopsinG protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals throughheterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]
Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior.[9] Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood.[10] Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates.[11]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors".Genomics.85 (3):372–85.doi:10.1016/j.ygeno.2004.11.010.PMID15718104.
Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF (November 2003). "Discovery of a null mutation in a human trace amine receptor gene".Genomics.82 (5):531–6.doi:10.1016/S0888-7543(03)00173-3.PMID14559210.
Notes: (1) TAAR1 activity of ligands varies significantly between species. Some agents that are TAAR1 ligands in some species are not in other species. This navbox includes all TAAR1 ligands regardless of species. (2) See the individual pages for references, as well as theList of trace amines,TAAR, andTAAR1 pages. See also:Receptor/signaling modulators
