TAAR6 belongs to thetrace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines likedopamine,norepinephrine,serotonin, andhistamine. Trace amines were thought to be 'false transmitters' that displace classicbiogenic amines from their storage and act on transporters in a fashion similar to theamphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[7][8] RNA expression analysis shows hTAAR6 is expressed in the hippocampus, where murine TAAR receptors have been shown to be involved with neurogenesis.[9]
Computational modeling suggests TAAR6 can bind to the foul smelling compounds produced by rotting flesh,putrescine andcadaverine.[10]
TAAR6 mutant mice have differences in behavior compared with wild-type mice.[11] Also, they have elevated brainserotonin levels in several brain regions and enhanced hypothermic response to5-HT1A receptor agonist8-OH-DPAT.[12]
^Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors".Genomics.85 (3):372–85.doi:10.1016/j.ygeno.2004.11.010.PMID15718104.
Cao Q, Martinez M, Zhang J, Sanders AR, Badner JA, Cravchik A, et al. (July 1997). "Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees".Genomics.43 (1):1–8.doi:10.1006/geno.1997.4815.PMID9226366.
Kaufmann CA, Suarez B, Malaspina D, Pepple J, Svrakic D, Markel PD, et al. (July 1998). "NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees".American Journal of Medical Genetics.81 (4):282–9.doi:10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W.PMID9674972.
Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors".Genomics.85 (3):372–85.doi:10.1016/j.ygeno.2004.11.010.PMID15718104.
Notes: (1) TAAR1 activity of ligands varies significantly between species. Some agents that are TAAR1 ligands in some species are not in other species. This navbox includes all TAAR1 ligands regardless of species. (2) See the individual pages for references, as well as theList of trace amines,TAAR, andTAAR1 pages. See also:Receptor/signaling modulators
