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Sultopride

From Wikipedia, the free encyclopedia
Antipsychotic medication
Pharmaceutical compound
Sultopride
Clinical data
Trade namesBarnetil, Barnotil, Topral
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral,IM
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Eliminationhalf-life3–5 hours
Identifiers
  • N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.053.293Edit this at Wikidata
Chemical and physical data
FormulaC17H26N2O4S
Molar mass354.47 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1cc(c(OC)cc1)C(=O)NCC2N(CC)CCC2)CC
  • InChI=1S/C17H26N2O4S/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20) checkY
  • Key:UNRHXEPDKXPRTM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Sultopride (trade namesBarnetil,Barnotil,Topral) is anatypical antipsychotic of thebenzamidechemical class used inEurope,Japan, andHong Kong for the treatment ofschizophrenia.[2][3][4] It was launched bySanofi-Aventis in 1976.[2] Sultopride acts as aselectiveD2 andD3 receptorantagonist.[5] It has also been shown to have clinically relevantaffinity for theGHB receptor as well, a property it shares in common withamisulpride andsulpiride.[6]

Pharmacology

[edit]
Sultopride
SiteKiSpeciesRef
D21.6Human[7]
D33.8Human[7]

References

[edit]
  1. ^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
  2. ^abMiguel Vela J, Buschmann H, Holenz J, Párraga A, Torrens A (2007).Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH.ISBN 978-3-527-31058-6.
  3. ^Swiss Pharmaceutical Society (2000).Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers.ISBN 3-88763-075-0.
  4. ^European Drug Index (4th ed.). Boca Raton: CRC Press. 1998.ISBN 3-7692-2114-1.
  5. ^Burstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, et al. (December 2005). "Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist".The Journal of Pharmacology and Experimental Therapeutics.315 (3):1278–1287.doi:10.1124/jpet.105.092155.PMID 16135699.S2CID 2247093.
  6. ^Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (April 1994). "Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics".European Journal of Pharmacology.256 (2):211–214.doi:10.1016/0014-2999(94)90248-8.PMID 7914168.
  7. ^abBurstein ES, Ma J, Wong S, Gao Y, Pham E, Knapp AE, et al. (December 2005). "Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist".The Journal of Pharmacology and Experimental Therapeutics.315 (3):1278–1287.doi:10.1124/jpet.105.092155.PMID 16135699.S2CID 2247093.
Typical
Disputed
Atypical
Others
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
Receptor
(ligands)
GHBRTooltip GHB receptor
GABABTooltip γ-Aminobutyric acid B receptor
Transporter
(blockers)
MCTsTooltip Monocarboxylate transporters
SMCTsTooltip Sodium-coupled monocarboxylate transporters
VIATTTooltip Vesicular inhibitory amino acid transporter
Enzyme
(inhibitors)
SSRTooltip Succinic semialdehyde reductase
GHBDHTooltip 4-Hydroxybutyrate dehydrogenase
HOTTooltip Hydroxyacid-oxoacid transhydrogenase
ADHTooltip Alcohol dehydrogenase
ALDHTooltip Aldehyde dehydrogenase
Stub icon

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