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Sulfafurazole

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Chemical compound
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Not to be confused withsulfadiazine.

Pharmaceutical compound
Sulfafurazole
Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa601049
Pregnancy
category
  • To be avoided within two months of term
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
ExcretionExcreted unchanged in urine
Identifiers
  • 4-Amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.004.418Edit this at Wikidata
Chemical and physical data
FormulaC11H13N3O3S
Molar mass267.30 g·mol−1
3D model (JSmol)
Melting point194 °C (381 °F)
  • Cc1c(C)noc1NS(=O)(=O)c2ccc(N)cc2
  • InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
  • Key:NHUHCSRWZMLRLA-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

Sulfafurazole (INN, also known assulfisoxazole) is asulfonamideantibacterial with a dimethyl-isoxazole substituent. It possessesantibiotic activity against a wide range ofGram-negative andGram-positive organisms.[1] It is sometimes given in combination witherythromycin (seeerythromycin/sulfafurazole) orphenazopyridine. It is used locally in a 4% solution orointment.

References

[edit]
  1. ^Holmes NE, Grauson ML (October 2017). "Sulfonamides". In Paterson DL, McCarthy JS, Mouton JW, Mills J, Grayson ML, Cosgrove SE, Crowe S, Hope W (eds.).Kucers' The Use of Antibiotics (7th ed.). CRC Press. pp. 1571–1624.ISBN 978-1-4987-4796-7.

External links

[edit]
Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-acting
Intermediate-acting
Long-acting
Other/ungrouped
Combinations
Other DHPS inhibitors
Quinolones
(inhibit bacterial
topoisomerase
and/orDNA gyrase,
thereby inhibiting
DNA replication)
1st generation
Fluoroquinolones
2nd generation
3rd generation
4th generation
Veterinary
Newer non-fluorinated
Related (DG)
Anaerobic DNA
inhibitors
Nitroimidazole derivatives
RNA synthesis
Rifamycins/
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Lipiarmycins
Antibiotics
Sulfonamides
Antivirals
Fluoroquinolones
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CARTooltip Constitutive androstane receptor
PXRTooltip Pregnane X receptor
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