| Streptomyces clavuligerus | |
|---|---|
Scientific classification | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Actinomycetota |
| Class: | Actinomycetes |
| Order: | Streptomycetales |
| Family: | Streptomycetaceae |
| Genus: | Streptomyces |
| Species: | S. clavuligerus |
| Binomial name | |
| Streptomyces clavuligerus Higgens & Kastner 1971 | |
Streptomyces clavuligerus is a species ofGram-positivebacterium notable for producingclavulanic acid.[1]
S. clavuligerus ATCC 27064 (NRRL 3585, DSM 738) was first described by Higgens and Kastner (1971), who isolated it from a South American soil sample.[2] Its name refers to the shape of itsspore-bearinghyphal branches: from the Latinclavula 'little club' andigerus 'bearing'.S. clavuligerus spores are gray to grayish-green.[2]
S. clavuligerus produces over 20secondary metabolites, including manybeta-lactamantibiotics such asclavulanic acid,cephamycin C,deacetoxycephalosporin C,penicillin N (an intermediate in cephamycin C pathway), and at least four other clavams.[3][4] Non-β-lactam antibiotics include holomycin and an antibiotic complex, MM 19290, related totunicamycin;[5] a beta-lactamase-inhibitory protein (BLIP) has also been described.[6] ForS. clavuligerus ATCC 27064, a teleocidin biosynthetic gene cluster was identified in early isolates held at ATCC, apparently missing from later isolates used for industrial production of clavulanic acid.[7]
Another important characteristic ofS. clavuligerus is that it is not able to useglucose as a carbon source because it lacks a glucose transport system.[8][9]
It also possesses all the enzymes of theurea cycle, which is unusual for aprokaryote, although it is not clear whether theurea cycle is functional.[10]
{{cite journal}}:Cite journal requires|journal= (help)Alvarez-Alvarez, R.; Rodriguez-Garcia, A.; Santamarta, I.; Perez-Redondo, R.; Prieto-Dominguez, A.; Martinez-Burgo, Y.; Liras, Paloma (May 2014)."Transcriptomic analysis ofStreptomyces clavuligerus Delta ccaR:: tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation".Microbial Biotechnology.7 (3):221–231.doi:10.1111/1751-7915.12109.PMC 3992018.PMID 24450885.
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