 | |
| Names | |
|---|---|
| IUPAC name L-leucyl-L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonine | |
| Other names LVVYPWT; LVV-hemorphin-4 | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
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| |
| Properties | |
| C45H64N8O10 | |
| Molar mass | 877.037 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Spinorphin is anendogenous, non-classicalopioid peptide of thehemorphin family[1] first isolated from thebovinespinal cord (hence the prefixspin-)[2] and acts as a regulator of theenkephalinases, a class ofenzymes that break down endogenous theenkephalinpeptides.[3] It does so by inhibiting theenzymesaminopeptidase N (APN),dipeptidyl peptidase III (DPP3),angiotensin-converting enzyme (ACE), andneutral endopeptidase (NEP).[3] Spinorphin is aheptapeptide and has theamino acid sequence Leu-Val-Val-Tyr-Pro-Trp-Thr (LVVYPWT).[3] It has been observed to possessantinociceptive,[4]antiallodynic,[4] andanti-inflammatory properties.[1] Themechanism of action of spinorphin has not been fully elucidated (i.e., how it acts to inhibit the enkephalinases), but it has been found to act as anantagonist of theP2X3 receptor,[5] and as a weakpartial agonist/antagonist of theFP1 receptor.[1]
