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Somatostatin receptor 4

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SSTR4
Identifiers
AliasesSSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDsOMIM:182454;MGI:105372;HomoloGene:20286;GeneCards:SSTR4;OMA:SSTR4 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SSTR4
Genomic location for SSTR4
Band20p11.21Start23,035,312bp[1]
End23,039,237bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SSTR4
Genomic location for SSTR4
Band2 G3|2 73.44 cMStart148,237,264bp[2]
End148,238,687bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • cingulate gyrus

  • right frontal lobe

  • anterior cingulate cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • Brodmann area 9

  • amygdala

  • islet of Langerhans

  • hippocampus proper
Top expressed in
  • intestinal villus

  • Ileal epithelium

  • perirhinal cortex

  • entorhinal cortex

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • CA3 field

  • superior frontal gyrus

  • granulocyte

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6754

20608

Ensembl

ENSG00000132671

ENSMUSG00000037014

UniProt

P31391

P49660

RefSeq (mRNA)

NM_001052

NM_009219

RefSeq (protein)

NP_001043

NP_033245

Location (UCSC)Chr 20: 23.04 – 23.04 MbChr 2: 148.24 – 148.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Somatostatin receptor type 4 is aprotein that in humans is encoded by theSSTR4gene.[5][6]

Function

[edit]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000132671Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000037014Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schüle R (May 1993)."Cloning and characterization of a fourth human somatostatin receptor".Proceedings of the National Academy of Sciences of the United States of America.90 (9):4196–200.Bibcode:1993PNAS...90.4196R.doi:10.1073/pnas.90.9.4196.PMC 46473.PMID 8483934.
  6. ^ab"Entrez Gene: SSTR4 somatostatin receptor 4".

Further reading

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External links

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Neurotransmitter
Adrenergic
Purinergic
Serotonin
Other
Metabolites and
signaling molecules
Eicosanoid
Other
Peptide
Neuropeptide
Other
Miscellaneous
Taste, bitter
Orphan
Other
Adhesion
Orphan
Other
Taste, sweet
Other
Frizzled
Smoothened
GH
(somatotropin)
GHIH
(somatostatin)
GHRH
(somatocrinin)
GHS
(ghrelin)
IGF-1
(somatomedin)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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