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Somatostatin receptor 1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SSTR1
Identifiers
AliasesSSTR1, SRIF-2, SS-1-R, SS1-R, SS1R, Somatostatin receptor 1
External IDsOMIM:182451;MGI:98327;HomoloGene:820;GeneCards:SSTR1;OMA:SSTR1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SSTR1
Genomic location for SSTR1
Band14q21.1Start38,207,904bp[1]
End38,213,067bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for SSTR1
Genomic location for SSTR1
Band12 C1|12 25.61 cMStart58,258,558bp[2]
End58,261,230bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • jejunal mucosa

  • Brodmann area 46

  • duodenum

  • prefrontal cortex

  • middle temporal gyrus

  • pars reticulata

  • pars compacta

  • Brodmann area 23

  • dorsolateral prefrontal cortex
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • embryo

  • superior frontal gyrus

  • primary visual cortex

  • ventromedial nucleus

  • anterior amygdaloid area

  • primary motor cortex

  • subiculum

  • dorsomedial hypothalamic nucleus

  • arcuate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6751

20605

Ensembl

ENSG00000139874

ENSMUSG00000035431

UniProt

P30872

P30873

RefSeq (mRNA)

NM_001049

NM_009216

RefSeq (protein)

NP_001040

NP_033242

Location (UCSC)Chr 14: 38.21 – 38.21 MbChr 12: 58.26 – 58.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Somatostatin receptor type 1 is aprotein that in humans is encoded by theSSTR1gene.[5][6]

Function

[edit]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000139874Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000035431Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms".Genomics.15 (2):449–52.doi:10.1006/geno.1993.1088.PMID 8449518.
  6. ^ab"Entrez Gene: SSTR1 somatostatin receptor 1".

Further reading

[edit]

External links

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Neurotransmitter
Adrenergic
Purinergic
Serotonin
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Metabolites and
signaling molecules
Eicosanoid
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Peptide
Neuropeptide
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Miscellaneous
Taste, bitter
Orphan
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Adhesion
Orphan
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Taste, sweet
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Frizzled
Smoothened
GH
(somatotropin)
GHIH
(somatostatin)
GHRH
(somatocrinin)
GHS
(ghrelin)
IGF-1
(somatomedin)

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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