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Sodelglitazar

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Sodelglitazar
Clinical data
Pregnancy
category
  • N/A
ATC code
  • None
Legal status
Legal status
  • Investigational
Identifiers
  • [4-[[[2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methyl]sulfanyl]-2-methylphenoxy]-2-methylpropanoic acid[1]
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H21F4NO3S2
Molar mass499.54 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=C(C=C(C=C3)C(F)(F)F)F)C)OC(C)(C)C(=O)O
  • InChI=1S/C23H21F4NO3S2/c1-12-9-15(6-8-18(12)31-22(3,4)21(29)30)32-11-19-13(2)28-20(33-19)16-7-5-14(10-17(16)24)23(25,26)27/h5-10H,11H2,1-4H3,(H,29,30)
  • Key:ZUGQWAYOWCBWGM-UHFFFAOYSA-N

Sodelglitazar, formerly known asGW 677954, is a thiazolePPARδreceptor agonist developed byGlaxoSmithKline.[2] While it is primarily active at the PPARδ receptor, it is considered a pan agonist with activity atPPARα andPPARγ receptors.[3]

Safety

[edit]

Phase 2 studies were terminated prior to completion due to safety findings inrodent studies.[4]

See also

[edit]

References

[edit]
  1. ^US abandoned 7105551, Rodolfo C, Marie GR, Hurst III LM, Lawrence SM, "Thiazole derivatives for treating ppar related disorders", published 1 April 2004, assigned to SmithKlineBeecham 
  2. ^Liu XY, Wang RL, Xu WR, Tang LD, Wang SQ, Chou KC (October 2011). "Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar".Protein and Peptide Letters.18 (10):1021–7.doi:10.2174/092986611796378701.PMID 21592078.
  3. ^Ottow E, Weinmann H (2008).Nuclear Receptors as Drug Targets. Wiley. pp. 380–.ISBN 978-3-527-31872-8. Retrieved2 April 2013.
  4. ^"A randomised, double-blind, parallel group, placebo-controlled, multicentre study to evaluate the safety, tolerability and efficacy of oral GW677954 capsules 2.5mg, 5mg, 10mg and 20mg a day for 24 weeks in overweight dyslipidaemic subjects"(PDF). GlaxoSmithKline. 2013-09-01. Archived fromthe original(PDF) on 6 March 2017.
PPARTooltip Peroxisome proliferator-activated receptormodulators
PPARαTooltip Peroxisome proliferator-activated receptor alpha
PPARδTooltip Peroxisome proliferator-activated receptor delta
PPARγTooltip Peroxisome proliferator-activated receptor gamma
Non-selective


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