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SoRI-9804

From Wikipedia, the free encyclopedia
SoRI-9804
Names
Preferred IUPAC name
N-(Diphenylmethyl)-2-phenylquinazolin-4-amine
Other names
Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine; 4-((Diphenylmethyl)amino)-2-phenylquinazoline
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C27H21N3/c1-4-12-20(13-5-1)25(21-14-6-2-7-15-21)29-27-23-18-10-11-19-24(23)28-26(30-27)22-16-8-3-9-17-22/h1-19,25H,(H,28,29,30)
    Key: LJIQXEUCYVPWRY-UHFFFAOYSA-N
  • C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=N2)NC(C4=CC=CC=C4)C5=CC=CC=C5
Properties
C27H21N3
Molar mass387.486 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

SoRI-9804 is a positiveallosteric modulator ofdopamine transporters. Unlike others in its series & traditionalDRI ligands, it inhibits the release of dopamine in addition to inhibiting the reuptake of released dopamine back into the transporter.[1]

See also

[edit]

References

[edit]
  1. ^Rothman, Richard B.; Dersch, Christina M.; Ananthan, Subramaniam; Partilla, John S. (May 2009)."Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release".Journal of Pharmacology and Experimental Therapeutics.329 (2):718–28.doi:10.1124/jpet.108.149088.PMC 2672863.PMID 19244097.


D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists


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