Movatterモバイル変換

Small temporal RNA

From Wikipedia, the free encyclopedia

Small temporal RNA (abbreviatedstRNA) regulates gene expression duringroundworm development by preventing themRNAs they bind from being translated.^[1] In contrast tosiRNA, stRNAs downregulate expression of target RNAs after translation initiation without affectingmRNA stability.^[2] Nowadays, stRNAs are better known asmiRNAs.

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNaseDicer/DCR-1 and members of theRDE-1/AGO1 family of proteins, which are better known for their roles inRNA interference (RNAi). stRNAs may function to control temporal identity during development inC. elegans and other organisms.^[3]

References

[edit]

^Ambros V (August 2001). "Development. Dicing up RNAs".Science.293 (5531):811–3.doi:10.1126/science.1064400.PMID 11486075.S2CID 45706655.
^Grosshans H, Slack FJ (January 2002)."Micro-RNAs: small is plentiful".The Journal of Cell Biology.156 (1):17–21.doi:10.1083/jcb.200111033.PMC 2173595.PMID 11781331.
^Banerjee D, Slack F (February 2002)."Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression".BioEssays.24 (2):119–29.doi:10.1002/bies.10046.PMID 11835276.

v t e Types ofRNA
Protein synthesis	Messenger RNA Ribosomal RNA Signal recognition particle RNA Transfer RNA Transfer-messenger RNA
RNA processing	Small nuclear RNA Small nucleolar RNA Guide RNA RNase P RNase MRP Y RNA
Gene regulation	Antisense RNA Cis-natural antisense transcript CRISPR RNA Long noncoding RNA MicroRNA Piwi-interacting RNA Repeat-associated siRNA Small interfering RNA Small temporal RNA Trans-acting siRNA Short hairpin RNA
Cis-regulatory elements	Riboswitch SECIS element
Parasites	Retrotransposon Reverse transcribing virus RNA virus Viroid
Other	Telomerase RNA Vault RNA List of RNAs

Types ofnucleic acids

Constituents

Ribonucleic acids
(coding,non-coding)

Translational	Messenger precursor, heterogenous nuclear modified Messenger Transfer Ribosomal Transfer-messenger
Regulatory	Interferential Micro Small interfering Piwi-interacting Antisense Processual Small nuclear Small nucleolar Small Cajal Body RNAs Y RNA Enhancer RNAs
Others	Guide Ribozyme Small hairpin Small temporal Trans-acting small interfering Subgenomic messenger

Deoxyribonucleic
acids

Analogues

Cloning vectors

Category

Thismolecular biology article is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Small_temporal_RNA&oldid=1221398357"

Categories:

Hidden category:

All stub articles

[8]ページ先頭