Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Sinopharm WIBP COVID-19 vaccine

From Wikipedia, the free encyclopedia
Vaccine against COVID-19

For other uses, seeSinopharm COVID-19 vaccine.
Pharmaceutical compound
Sinopharm WIBP COVID-19 vaccine
Vaccine description
TargetSARS-CoV-2
Vaccine typeInactivated
Clinical data
Other namesZhongkangkewei (Chinese:众康可维)
Routes of
administration
Intramuscular
ATC code
  • None
Legal status
Legal status
  • Full and emergency authorizations
Full list of Sinopharm WIBP authorizations
Identifiers
CAS Number
DrugBank
Part ofa series on the
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
virus iconCOVID-19 portal

TheSinopharm WIBP COVID-19 vaccine, also known asWIBP-CorV,[2][3] is one of twoinactivated virusCOVID-19 vaccines developed bySinopharm. Peer-reviewed results show that the vaccine is 72.8% effective against symptomatic cases and 100% against severe cases (26 cases in vaccinated group vs. 95 cases in placebo group).[4] The other inactivated virus COVID-19 vaccine developed by Sinopharm is theBIBP vaccine (BBIBP-CorV) which is comparably more successful. 1 billion doses are expected to be produced per year.

Medical uses

[edit]

The vaccine is given byintramuscular injection. The administered is 2 doses in 3 weeks.[5][6][7]

Efficacy

[edit]

In May 2021, peer-reviewed results published inJAMA of Phase III trials inUnited Arab Emirates andBahrain showed that the vaccine is 72.8% effective against symptomatic cases and 100% against severe cases (26 cases in vaccinated group vs. 95 cases in placebo group). 12,743 people received the vaccine and 12,737 people received the placebo in these trials.[4]

Manufacturing

[edit]

In June 2021, a new factory started production with the capacity to manufacture 1 billion doses annually.[8]

History

[edit]

In April 2020, China approved clinical trials for a candidate COVID-19 vaccine developed bySinopharm's Beijing Institute of Biological Products (BIBP)[9] and the Wuhan Institute of Biological Products (WIBP).[10] Both vaccines are chemically-inactivated whole virus vaccines forCOVID-19.[citation needed]

On August 13, 2020, theWuhan Institute of Biological Products published interim results of its Phase I (96 adults) and Phase II (224 adults) clinical studies. The report noted the vaccine had a low rate of adverse reactions and demonstratedimmunogenicity, but longer-term assessment of safety and efficacy would require Phase III trials.[10]

Clinical trials

[edit]

In March 2021,Cayetano Heredia University running the BIBP and WIBP trials in Peru announced they were seeking to suspend and unblind participants in the WIBP trials for lower efficacy and offer the participants the BIBP vaccine instead, which was showing efficacy.[11]

Authorizations

[edit]
See also:List of COVID-19 vaccine authorizations § Sinopharm WIBP

On February 25, 2021, China approved the vaccine for general use.[12]

According toThe New York Times, the vaccine is only approved for limited use inUnited Arab Emirates.[13] On August 19, 2021, the Philippines approved the vaccine for emergency use authorization.[14]

References

[edit]
  1. ^"Patent Landscape Report COVID-19-related vaccines and therapeutics"(PDF).
  2. ^Evidence Assessment: Sinopharm/BBIBP COVID-19 vaccine(PDF) (Presentation). World Health Organization. 29 April 2021. Retrieved10 July 2021.Evaluated BBIBP-CorV & WIBP-CorV
  3. ^Hadj Hassine I (July 2022)."Covid-19 vaccines and variants of concern: A review".Reviews in Medical Virology.32 (4) e2313.doi:10.1002/rmv.2313.PMC 8646685.PMID 34755408.S2CID 243939603.
  4. ^abAl Kaabi N, Zhang Y, Xia S, Yang Y, Al Qahtani MM, Abdulrazzaq N, Al Nusair M, Hassany M, Jawad JS, Abdalla J, Hussein SE, Al Mazrouei SK, Al Karam M, Li X, Yang X, Wang W, Lai B, Chen W, Huang S, Wang Q, Yang T, Liu Y, Ma R, Hussain ZM, Khan T, Saifuddin Fasihuddin M, You W, Xie Z, Zhao Y, Jiang Z, Zhao G, Zhang Y, Mahmoud S, ElTantawy I, Xiao P, Koshy A, Zaher WA, Wang H, Duan K, Pan A, Yang X (July 2021)."Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial".JAMA.326 (1):35–45.doi:10.1001/jama.2021.8565.PMC 8156175.PMID 34037666.
  5. ^China National Biotec Group Company Limited (29 October 2020)."Multicenter, Randomized, Double Blind, Parallel Placebo Controlled, Phase III Clinical Trial to Evaluate the Protective Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above".ClinicalTrials.gov. G42 Healthcare company, Abu Dhabi Health Services Company, Wuhan Institute of Biological Products Co., Ltd, Beijing Institute of Biological Products Co Ltd.
  6. ^Universidad Peruana Cayetano Heredia (3 November 2020)."Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) to Prevent COVID-19 in Healthy Adult Population In Peru Healthy Adult Population In Peru (Covid-Peru)".ClinicalTrials.gov. National University of San Marcos, Peru. NCT04612972.
  7. ^"Two Chinese-developed COVID-19 vaccines under review". National Medical Products Administration. 25 February 2021. Retrieved11 April 2021.
  8. ^"Sinopharm's Wuhan affiliate boosts COVID-19 shot annual capacity to 1 billion doses".CNA. Archived fromthe original on 2021-06-08. Retrieved2021-06-08.
  9. ^Xia S, Zhang Y, Wang Y, Wang H, Yang Y, Gao GF, Tan W, Wu G, Xu M, Lou Z, Huang W, Xu W, Huang B, Wang H, Wang W, Zhang W, Li N, Xie Z, Ding L, You W, Zhao Y, Yang X, Liu Y, Wang Q, Huang L, Yang Y, Xu G, Luo B, Wang W, Liu P, Guo W, Yang X (January 2021)."Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial".The Lancet. Infectious Diseases.21 (1):39–51.doi:10.1016/s1473-3099(20)30831-8.PMC 7561304.PMID 33069281.
  10. ^abXia S, Duan K, Zhang Y, Zhao D, Zhang H, Xie Z, Li X, Peng C, Zhang Y, Zhang W, Yang Y, Chen W, Gao X, You W, Wang X, Wang Z, Shi Z, Wang Y, Yang X, Zhang L, Huang L, Wang Q, Lu J, Yang Y, Guo J, Zhou W, Wan X, Wu C, Wang W, Huang S, Du J, Meng Z, Pan A, Yuan Z, Shen S, Guo W, Yang X (September 2020)."Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials".JAMA.324 (10):951–960.doi:10.1001/jama.2020.15543.PMC 7426884.PMID 32789505.
  11. ^"COMUNICADO A LA OPINIÓN PÚBLICA".Universidad Peruana Cayetano Heredia. March 9, 2021.
  12. ^"China approves two more domestic COVID-19 vaccines for public use".Reuters. 2021-02-25. Retrieved2021-03-30.
  13. ^Zimmer C, Corum J, Wee SL (10 June 2020)."Coronavirus Vaccine Tracker".The New York Times.ISSN 0362-4331. Retrieved2021-03-30.
  14. ^De Vera A (August 25, 2021)."FDA grants EUA to COVID-19 vaccine Sinopharm manufactured by Wuhan affiliate". Manila Bulletin.

External links

[edit]
Scholia has a profile forWIBP-CorV(Q106322660).
Development
Classes
Administration
Vaccines
Bacterial
Viral
Protozoan
Helminthiasis
Other
Inventors/
researchers
Controversy
Related
Pre-pandemic
2020
2021
2022
2023
Africa
Northern
Eastern
Southern
Central
Western
Asia
Central/North
East
Mainland China
South
India
By location
Southeast
Malaysia
Philippines
West
Europe
United Kingdom
By location
Eastern
Western Balkans
European Union
EFTA countries
Microstates
North
America
Atlantic
Canada
Caribbean
Countries
British Overseas Territories
Caribbean Netherlands
French West Indies
US insular areas
Central America
United States
responses
By location
Oceania
Australia
New Zealand
South
America
Others
Culture and
entertainment
Arts and
cultural heritage
Education
By country
Sports
By country
By sport
Society
and rights
Social impact
Labor
Human rights
Legal
Minority
Religion
Economic
By country
By industry
Supply and trade
Financial markets
Information
Misinformation
Politics
Political impact
Protests
International relations
Language
Others
Health issues
Medical topics
Testing and
epidemiology
Apps
Prevention
Vaccines
Topics
Authorized
DNA
Inactivated
mRNA
Subunit
Viral vector
Virus-like particles
In trials
Attenuated
DNA
Inactivated
RNA
Subunit
Viral vector
Virus-like particles
Deployment
by location
Africa
Asia
Europe
North America
Oceania
South America
Others
Treatment
Monoclonal antibodies
Small molecule antivirals
Specific
General
Institutions
Hospitals and
medical clinics
Mainland China
Others
Organizations
Health
institutes
Pandemic
institutes
Relief funds
People
Medical
professionals
Researchers
Officials
WHO
By location
Others
Data (templates)
Global
Africa
Americas
Asia
Europe
Oceania
Others
Portals:
Retrieved from "https://en.wikipedia.org/w/index.php?title=Sinopharm_WIBP_COVID-19_vaccine&oldid=1315014151"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp