Senotherapeutics refers to therapeutic agents/strategies that specifically targetcellular senescence.[1] Senotherapeutics include emergingsenolytic/senoptotic small molecules that specifically induce cell death in senescent cells[2] and agents that inhibit the pro-inflammatory senescent secretome.[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.[citation needed]