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Senotherapy

From Wikipedia, the free encyclopedia
Basic research field

Senotherapeutics refers to therapeutic agents/strategies that specifically targetcellular senescence.[1] Senotherapeutics include emergingsenolytic/senoptotic small molecules that specifically induce cell death in senescent cells[2] and agents that inhibit the pro-inflammatory senescent secretome.[3] Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.[4] Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.[citation needed]

References

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  1. ^Childs et al. (2015).Cellular senescence in aging and age-related disease: from mechanisms to therapy Nature Medicine {{doi:10.1038/nm.4000}}
  2. ^Chang J., Wang Y.,Shao L. et al., & Zhou D. (2015).Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicinedoi:10.1038/nm.4010
  3. ^Xu et al. (2015).JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age PNAS {{doi: 10.1073/pnas.1515386112}}
  4. ^Burton and Faragher (2015).Cellular senescence: from growth arrest to immunogenic conversion AGE {{doi:10.1007/s11357-015-9764-2}}
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