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Selonabant

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Selonabant
Clinical data
Other namesANEB-001; ANEB001; V-24343; V24343
Drug classCannabinoid receptor antagonist;CannabinoidCB1 receptorantagonist;Cannabinoid antidote
Identifiers
  • N-tert-butyl-3-[(R)-(4-chlorophenyl)-[2-(trifluoromethyl)phenyl]methoxy]azetidine-1-carboxamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC22H24ClF3N2O2
Molar mass440.89 g·mol−1
3D model (JSmol)
  • CC(C)(C)NC(=O)N1CC(C1)O[C@H](C2=CC=C(C=C2)Cl)C3=CC=CC=C3C(F)(F)F
  • InChI=1S/C22H24ClF3N2O2/c1-21(2,3)27-20(29)28-12-16(13-28)30-19(14-8-10-15(23)11-9-14)17-6-4-5-7-18(17)22(24,25)26/h4-11,16,19H,12-13H2,1-3H3,(H,27,29)/t19-/m1/s1
  • Key:BNLYOVHLLDBOFZ-LJQANCHMSA-N

Selonabant (INNTooltip International Nonproprietary Name,USANTooltip United States Adopted Name; developmental code namesANEB-001,V-24343) is acannabinoidCB1 receptorantagonist which is under development for the treatment of acutecannabinoidintoxication.[1][2][3] It was also previously being developed to treatobesity, but development for this indication was discontinued.[1] The drug is administered byintravenous infusion.[1] It dramatically reduced the subjective effects ofΔ9-tetrahydrocannabinol (THC) in aclinical trial.[3] Selonabant is being developed by Vernalis and Anebulo Pharmaceuticals.[1][2] As of December 2024, it is inphase 2 trials.[1][2]

See also

[edit]

References

[edit]
  1. ^abcde"Anebulo Pharmaceuticals".AdisInsight. 26 December 2024. Retrieved25 February 2025.
  2. ^abc"Delving into the Latest Updates on Selonabant with Synapse".Synapse. 23 January 2025. Retrieved25 February 2025.
  3. ^abGorbenko AA, Heuberger JA, Juachon M, Klaassen E, Tagen M, Lawler JF, et al. (February 2025)."CB1 Receptor Antagonist Selonabant (ANEB-001) Blocks Acute THC Effects in Healthy Volunteers: A Phase II Randomized Controlled Trial".Clinical Pharmacology and Therapeutics.117 (5):1427–1436.doi:10.1002/cpt.3581.PMC 11993283.PMID 39898464.
Receptor
(ligands)
CB1Tooltip Cannabinoid receptor type 1
Agonists
(abridged,
full list)
Inverse agonists
Antagonists
CB2Tooltip Cannabinoid receptor type 2
Agonists
Antagonists
NAGly
(
GPR18)
Agonists
Antagonists
GPR55
Agonists
Antagonists
GPR119
Agonists
Transporter
(modulators)
eCBTsTooltip Endocannabinoid transporter
Enzyme
(modulators)
FAAHTooltip Fatty acid amide hydrolase
MAGL
ABHD6
ABHD12
Others
  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)
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