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| Other names | Selanc;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline |
| Routes of administration | Nasal muscosa, IV |
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| Chemical and physical data | |
| Formula | C33H57N11O9 |
| Molar mass | 751.887 g·mol−1 |
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Selank (Russian: Cеланк) is anootropic,anxiolyticpeptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with thesequence Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). It is a synthetic analogue of humantuftsin.
Selank is a synthetic analogue of the immunomodulatory peptidetuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression ofInterleukin-6 (IL-6) and affect the balance ofT helper cellcytokines.[1] It has been shown to influence the concentration ofmonoamine neurotransmitters[2] and induce metabolism ofserotonin.[3][4] Selank has also been found to rapidly elevate the expression ofbrain-derived neurotrophic factor (BDNF) in thehippocampus of rats.[5]
Selank, as well as a related peptide drug,Semax, have been found to inhibitenzymes involved in the degradation ofenkephalins and otherendogenous regulatorypeptides, and this action may be involved in their effects.[6] It has also been found to affect the activity ofcarboxypeptidase H andphenylmethylsulfonylfluoride-inhibitedcarboxypeptidase in rat nervous system tissue.[7]
Selank has been found to produceantidepressant-like effects inanimal models ofdepression andanhedonia.[8]
In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment ofgeneralized anxiety disorder (GAD).[1] Selank has an advantage over traditional anxiety treatments, such asbenzodiazepines andbarbiturates, as it has nosedating or negative cognitive side effects and no associatedaddiction or withdrawal problems.[citation needed]
Selank is closely related to another nootropic drug,Semax, also developed by the Institute of Molecular Genetics in Russia. This drug is currently available in Russian and Ukrainian pharmacies.[9]
As with alllyophilized peptides, it needs refrigeration to remain stable within sterile water solutions, such as bacteriostatic water concentrations.
