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Schering-Plough

From Wikipedia, the free encyclopedia
Pharmaceutical company
Schering-Plough Corporation
Company typeSubsidiary
IndustryPharmaceuticals
Founded1971 (by merger with Plough, Inc.)
DefunctNovember 2009; 16 years ago (2009-11)
FateMerged withMerck & Co.
HeadquartersKenilworth, New Jersey
Key people
Fred Hassan
Final CEO & Chairman
RevenueUS$18.502 billion (2008)
US$1.903 billion (2008)
ParentMerck & Co.

Schering-Plough Corporation was an American pharmaceutical company. It was originally the U.S.subsidiary of the German companySchering AG, which was founded in 1851 byErnst Christian Friedrich Schering. As a result ofnationalization, it became an independent company. In 1971, the Schering Corporation merged with Plough, Inc. (founded by Memphis-based entrepreneurAbe Plough in 1908[1]) to form Schering-Plough. On November 4, 2009Merck & Co. merged with Schering-Plough with the new company taking the name of Merck & Co.

Schering-Plough manufactured several pharmaceuticaldrugs, the most well-known of which were theallergy drugsClaritin andClarinex, an anti-cholesterol drugVytorin, and abrain tumor drugTemodar. These are now available from Merck & Co.[2]

Schering-Plough also owned and operated the major foot care brand nameDr. Scholl's and the skin care lineCoppertone. These also became a part of the new company.[3]

As of June 2005[update], Schering-Plough had 1.4% market share in the U.S., placing it seventeenth in the top twenty pharmaceutical corporations by sales compiled byIMS Health.[citation needed]

Schering-Plough was a full member of theEuropean Federation of Pharmaceutical Industries and Associations (EFPIA),[4] a membership which is also maintained by the new Merck & Co.[5]

History

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Pharmaceuticals and consumer products

[edit]

Schering was founded in 1851 byErnst Christian Friedrich Schering asSchering AG inGermany.[citation needed]

Plough, Incorporated was founded by theMemphis, Tennessee area entrepreneur Abe Plough (1892–1984) in 1908. He borrowed $125 from his father to start the business at age sixteen. As a one-man business, he mixed "Plough's Antiseptic Healing Oil," a "sure cure for any ill of man or beast," and sold it off a horse-drawn buggy.[1]

Plough's acquisitions included St Joseph's Aspirin for children,[1]Maybelline cosmetics, andCoppertone skin care products. Plough also had a broadcasting division, operating radio stations inAtlanta, Georgia (WPLO-AM &FM);Baltimore, Maryland (WCAO-AM &FM);Boston, Massachusetts (WCOP-AM &FM);Chicago, Illinois (WJJD-AM &FM); andMemphis, Tennessee (WMPS-AM &FM).[6]

Following the entry of theUnited States intoWorld War II in 1941, U.S. PresidentFranklin Delano Roosevelt orderedSchering AG's U.S. assets be seized. These became the Schering Corporation. The company was placed under a government administratorship until 1952, when it was released, and its assets sold to the private sector.[citation needed]

In 1957, Schering acquired White Laboratories.[7]

In 1971, the Schering Corporation merged with Plough, Inc. At the time of the merger, Abe Plough became Chairman of the combined company.[8]In 2000, Schering-Plough bought a new campus inSummit, New Jersey fromNovartis.[citation needed]

On March 12, 2007, Schering-Plough Corp. purchasedOrganon BioSciences, the drug unit of Netherlands-basedAkzo Nobel, for $14.4 billion, giving the US pharmaceutical company an array of women's health products and numerous late-stage pipelines of experimental medicines.[9]Organon itself was founded in 1923 by Dr. Saal van Zwanenberg, the president of Zwanenberg's Slachterijen en Fabrieken.[citation needed]

On November 4, 2009 Schering-Plough merged withMerck & Co. and through areverse merger, Merck became a subsidiary of Schering-Plough, which renamed itself Merck.[10][11][12][13]

Animal health

[edit]

Coopers Animal Health

[edit]

One of Schering-Plough's plants, inUpper Hutt, New Zealand was the largest single site for the production of veterinaryvaccines in the world.[citation needed] This was primarily becauseNew Zealand's isolation has formed a naturalquarantine, leaving the country free ofrabies,foot and mouth,scrapie,bovine spongiform encephalopathy, and many other livestock diseases. It formerly hadechinococcosis, but this has been eradicated. The site was known locally asCoopers Animal Health, a trademark which originated in the 1850s with a British company,Cooper & Nephews; the Coopers brand name was still in use by Schering-Plough in Australia, but not elsewhere.[14]

Intervet

[edit]

As a result of the acquisition of Organon BioSciences, Schering-Plough bolstered its animal health business with theAkzo Nobel subsidiary Intervet, obtained control of the active pharmaceutical ingredient manufacturer,Diosynth and gained access to human vaccine production through the subsidiary Nobilon. The three companies comprising Organon BioSciences were Organon, Diosynth, and Intervet.[9] HomeAgain continues to use the Intervet name owned by Merck.

Merck Animal Health, MSD Animal Health

[edit]

After the merger of Schering-Plough with Merck the animal health division was still known as Intervet/Schering-Plough Animal Health.[15] A merger of Merial and Intervet/Schering-Plough was planned in 2010 but was abandoned in March 2011.[16] On June 29, 2011, the company announced that the animal health division would now be known asMerck Animal Health in the United States and Canada; it is now calledMSD Animal Health elsewhere in the world.[17]

Chief executives

[edit]
NameTenure
Willibald H. Conzen1971 – 1979
Richard J. Bennett1979 – January 31, 1982
Robert P. LucianoFebruary 1, 1982 – December 31, 1995
Richard J. KoganJanuary 1, 1996 – April 2003
Fred HassanApril 2003 – November 3, 2009

Medical products

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Prescription products

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Over-the-counter products (Most products sold toBayer, exceptCoppertone)

[edit]

Veterinary products

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Exercise drug

[edit]

Schering-Plough also received much publicity for a drugAICAR which mimics the effects of exercise, having especially potent effects when used alongside another drugGW1516 developed byGlaxoSmithKline.[citation needed]

Collaborative research

[edit]

In addition to internal research and development activitiesSchering-Plough was also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example innon-clinical safety assessment was theInnoMed PredTox.[29][30]

Controversy

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In 2004, Schering-Plough was accused of marketing gimmicks and payoffs to doctors for prescribing the company's pharmaceutical products.[31]

Schering-Plough entered aconsent decree with the FDA on March 6, 2002 due to manufacturing issues with its albuterol inhaler. It was ordered to pay $500 million US dollars to the US Treasury.[32]

References

[edit]
  1. ^abc"Abe Plough (1892-1984)".Tennessee Encyclopedia of History and Culture. Archived fromthe original on 2015-05-19.
  2. ^"Merck US Prescription Products". Merck.com.Archived from the original on November 4, 2010. RetrievedNovember 10, 2010.
  3. ^"Merck Consumer Products". Merck.com.Archived from the original on November 20, 2010. RetrievedNovember 10, 2010.
  4. ^"The Pharmaceutical Industry in Figures - 2008 Edition". European Federation of Pharmaceutical Industries and Associations (EFPIA). p. 49. Archived fromthe original on 2008-09-16. Retrieved2008-08-25.
  5. ^"Trade Association Memberships". Merck.com.Archived from the original on November 19, 2010. RetrievedNovember 8, 2010.
  6. ^Federal Communications Commission (FCC) memorandum opinion and order released Tuesday, December 15, 1970 pertaining to the approval of the transfer of control of Plough Broadcasting Co., Inc. from Plough, Inc. to Schering-Plough Corp. Retrieved January 16, 2019
  7. ^"Schering-Plough Corp facts, information, pictures - Encyclopedia.com articles about Schering-Plough Corp".www.encyclopedia.com.Archived from the original on 16 September 2016. Retrieved16 March 2018.
  8. ^"Answers - The Most Trusted Place for Answering Life's Questions".Answers.com.Archived from the original on 17 March 2018. Retrieved16 March 2018.
  9. ^ab"Schering-Plough Acquires Organon BioSciences". Medical Net News. 20 November 2007.Archived from the original on 20 December 2009. Retrieved19 June 2010.
  10. ^Singer, Natasha (March 10, 2009)."Merck to Buy Schering-Plough for $41.1 Billion".The New York Times.Archived from the original on May 12, 2011. Retrieved2009-11-14.
  11. ^"Merck and Schering-Plough to Complete Merger Today" (Press release). Merck & Co. November 3, 2009. Archived fromthe original on November 7, 2009. Retrieved2009-11-13.
  12. ^"New Merck Begins Operations" (Press release). Merck & Co. November 4, 2009. Archived fromthe original on December 8, 2009. Retrieved2009-11-13.
  13. ^Merck & Company, Inc. (November 12, 2009)."Notice of Reorganization Event". Posted on Thomson Reuters web site. Archived fromthe original(PDF) on February 1, 2016. Retrieved2009-11-13.
  14. ^"About Us".Coopers Animal Health.Archived from the original on 23 March 2016. Retrieved23 March 2016.
  15. ^"Intervet/Schering-Plough Animal Health". Intervet.com.Archived from the original on November 10, 2010. RetrievedNovember 10, 2010.
  16. ^"Merial, Intervet/Schering-Plough Call Off Merger". DVM Newsmagazine. 23 March 2011.Archived from the original on 18 May 2011. Retrieved27 July 2011.
  17. ^"Merck Announces New Name for Its Animal Health Division". Merck Animal Health. 29 June 2011.Archived from the original on 8 August 2011. Retrieved27 July 2011.
  18. ^Gupta SK, Ellinwood EH; Ellinwood (June 1988). "Liquid chromatographic assay and pharmacokinetics of quazepam and its metabolites following sublingual administration of quazepam".Pharm. Res.5 (6):365–8.doi:10.1023/A:1015907611170.PMID 3244647.S2CID 26259786.[dead link]
  19. ^"Zubrin". Intervet USA.Archived from the original on 18 January 2010. Retrieved19 June 2010.
  20. ^"Mometamax". Intervet USA.Archived from the original on 20 June 2010. Retrieved19 June 2010.
  21. ^"Feline Products". Intervet USA.Archived from the original on 20 September 2010. Retrieved19 June 2010.
  22. ^"Canine Products". Intervet USA.Archived from the original on 29 May 2010. Retrieved19 June 2010.
  23. ^"Optimmune". Intervet USA.Archived from the original on 6 July 2010. Retrieved19 June 2010.
  24. ^"Orbax". Intervet USA.Archived from the original on 29 May 2010. Retrieved19 June 2010.
  25. ^"Otomax". Intervet USA.Archived from the original on 6 August 2010. Retrieved19 June 2010.
  26. ^"Bantamine Paste". Intervet USA.Archived from the original on 6 February 2010. Retrieved19 June 2010.
  27. ^"Estrumate Prostaglandin". Intervet USA.Archived from the original on 14 September 2009. Retrieved19 June 2010.
  28. ^"Nuflor". Intervet USA.Archived from the original on 27 August 2010. Retrieved19 June 2010.
  29. ^Mattes, William B. (2008). "Public Consortium Efforts in Toxicogenomics". In Mendrick, Donna L.; Mattes, William B. (eds.).Essential Concepts in Toxicogenomics.Methods in Molecular Biology. Vol. 460. pp. 221–238.doi:10.1007/978-1-60327-048-9_11.ISBN 978-1-58829-638-2.PMID 18449490.
  30. ^"InnoMed PredTox Member Organizations". Archived fromthe original on 2008-09-26. Retrieved2008-08-25.
  31. ^Gardiner Harris, "As Doctors Write Prescriptions, Drug Company Writes a Check",The New York Times (June 27, 2004)Archived September 22, 2015, at theWayback Machine
  32. ^Petersen, Melody (18 May 2002)."Drug Maker to Pay $500 Million Fine For Factory Lapses".The New York Times.Archived from the original on 28 January 2018. Retrieved16 March 2018.

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