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Satavaptan

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Satavaptan
Clinical data
Other namesSR121463
ATC code
  • none
Identifiers
  • N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide
CAS Number
PubChemCID
ChemSpider
UNII
ECHA InfoCard100.211.853Edit this at Wikidata
Chemical and physical data
FormulaC33H45N3O8S
Molar mass643.80 g·mol−1
3D model (JSmol)
  • C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C
  • InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+ ☒N
  • Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Satavaptan (INN; developmental code nameSR121463, former tentative brand nameAquilda) is avasopressin V2 receptorantagonist[1] which was investigation bySanofi-Aventis and was under development for the treatment ofhyponatremia. It was also being studied for the treatment ofascites.[2] Development was discontinued in 2009.[3]

References

[edit]
  1. ^Soupart A, Gross P, Legros JJ, Alföldi S, Annane D, Heshmati HM, Decaux G (November 2006)."Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist".Clinical Journal of the American Society of Nephrology.1 (6):1154–60.doi:10.2215/CJN.00160106.PMID 17699341.
  2. ^Ginès P, Wong F, Watson H, Milutinovic S, del Arbol LR, Olteanu D (July 2008)."Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: a randomized trial".Hepatology.48 (1):204–13.doi:10.1002/hep.22293.PMID 18508290.
  3. ^"Satavaptan".Adis Insight. Springer Nature Switzerland AG.
Oxytocin
Vasopressin
V1A
V1B
V2
Unsorted
Others
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