Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Saripidem

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Saripidem
Clinical data
ATC code
  • none
Identifiers
  • N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-N-methylbutanamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H20ClN3O
Molar mass341.84 g·mol−1
3D model (JSmol)
  • O=C(N(C)Cc1c(nc2ccccn12)c3ccc(Cl)cc3)CCC
  • InChI=1S/C19H20ClN3O/c1-3-6-18(24)22(2)13-16-19(14-8-10-15(20)11-9-14)21-17-7-4-5-12-23(16)17/h4-5,7-12H,3,6,13H2,1-2H3 checkY
  • Key:LIFDPEORUVTOCP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Saripidem is asedative andanxiolytic drug in theimidazopyridine family, which is related to the better known drugszolpidem andalpidem.

Saripidem has a similar pharmacological profile to thebenzodiazepine family of drugs including sedative and anxiolytic properties, but itschemical structure is quite different from that of the benzodiazepine drugs, and saripidem is described as anonbenzodiazepine.

The mechanism of action by which saripidem produces its sedative and anxiolytic effects is by modulating the benzodiazepine binding site onGABAA receptors, however unlike many older GABAAagonists, saripidem is highly subtype selective and binds primarily to the ω1 subtype.[1]

References

[edit]
  1. ^Sanger DJ (March 1995). "Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue".Behavioural Pharmacology.6 (2):116–126.doi:10.1097/00008877-199503000-00003.PMID 11224318.S2CID 42888705.
GABAA
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Imidazoles
Monoureides
Neurosteroids
Nonbenzodiazepines
Phenols
Piperidinediones
Quinazolinones
Others
GABAB
H1
Antihistamines
Antidepressants
Antipsychotics
α2-Adrenergic
5-HT2A
Antidepressants
Antipsychotics
Others
Melatonin
Orexin
α2δVDCC
Others
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Flavonoids
Imidazoles
Kava constituents
Monoureides
Neuroactive steroids
Nonbenzodiazepines
Phenols
Piperidinediones
Pyrazolopyridines
Quinazolinones
Volatiles/gases
Others/unsorted
Retrieved from "https://en.wikipedia.org/w/index.php?title=Saripidem&oldid=1330498976"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2026 Movatter.jp