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Sandip Kumar Basu

From Wikipedia, the free encyclopedia
Indian molecular biologist

Sandip Kumar Basu
Born1944 (age 80–81)
Years activesince 1975
AwardsPadma Shri
Ranbaxy Medical Sciences Award
FICCI Life Sciences Award
Bhasin Foundation Biotechnology Award
ICMR B. R. Ambedkar Award
ISCA R. K. Dutt Memorial Award
Goyal Prize

Sandip Kumar Basu (born 1944) is an Indian molecular biologist and the holder of the J. C. Bose Chair of theNational Academy of Sciences, India, who is credited with innovations in the treatment protocols ofleishmaniasis,tuberculosis, viral infections, multidrug resistant cancer andarterosclerosis.[1] He was honored by theGovernment of India, in 2001, with the fourth highestIndian civilian award ofPadma Shri.[2]

Biography

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Sandip Kumar Basu was born inKolkata in the Indian state ofWest Bengal.[1] He graduated in 1962 from thePresidency College, Calcutta and secured his master's degree in 1964 from theUniversity College of Science. His doctoral research was at theCalcutta University which he successfully completed in 1968 on the topic,regulation ofmicrobialmetabolism and moved to USA for post doctoral research atKeck School of Medicine of USC, Los Angeles,University of California, Irvine School of Medicine,Public Health Research Institute, New York andMichael Reese Hospital, Chicago.[1] In 1975, he started his professional career by joining theUniversity of Texas Southwestern Medical School as a faculty member and stayed there till 1983 when he returned to India to join theIndian Institute of Chemical Biology, Kolkata. His next move was as the director of theInstitute of Microbial Technology, Chandigarh in 1986.[1] He became the director of theNational Institute of Immunology, New Delhi in 1991, a post he held till 2005 when he became the Professor of Eminence of the institute and continued there till 2010. He is theJ. C. Bose Chair Professor of theNational Academy of Sciences, India, placed at theNational Institute of Science Communication and Information Resources of theCouncil of Scientific and Industrial Research.[1]

Basu has been involved with research on the receptor basedintracellular delivery of drugs.[3][4][5][6] He is known to have introduced a new approach ofscavenger receptor-mediated targeting of therapeutic agents which has been demonstrated to be more effective than conventionalchemotherapy, in the treatment ofleishmaniasis,tuberculosis, viral infections, and multidrug resistant cancer.[1] His research has led to the discovery of new drug targets and also demonstrated the therapeutic effect of immunomodulator muramyl dipeptide onsalmonella by diverting the route the pathogens follow so as to survive within themacrophages.[1] He is credited with the establishment of the pathway oflow density lipoprotein receptors.[7][8] It is reported that Basu's work assistedMichael Stuart Brown andJoseph L. Goldstein, 1985Nobel Prize winners and his co-authors, in their research and in the development ofstatins, the cholesterol lowering drug.[1][9][10]

Basu is also credited with administrative achievements such as the establishment of a permanent campus at theInstitute of Microbial Technology, Chandigarh.[1] A former member of the Scientific Advisory Committee to theGovernment of India, he has served as the council member ofIndian National Science Academy, theIndian Academy of Sciences andNational Academy of Sciences, India and has also been the general secretary and vice president of NASI.[1]

Awards and honors

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Sandip Kumar Basu is an elected Fellow of theIndian National Science Academy, theIndian Academy of Sciences (FASc),[11]The World Academy of Sciences (FTWAS),[12] and theNational Academy of Sciences, India (FNASc).[13] He delivered theProfessor MRN Prasad Memorial Award Lecture in 1995, theDr. Yellapragada SubbaRow Memorial Award Lecture in 2002 and theB. K. Bachhawat Award Lecture in 2006.[1] He received the Ranbaxy Medical Sciences Award in 1995 followed byFICCI Life Sciences Award in 1996 and Bhasin Foundation Biotechnology Award, the next year. The year 1999 brought him two awards, the B. R. Ambedkar Award of theIndian Council of Medical Research and the R. K. Dutt Memorial Award of the International Science Congress Associations.[1] A recipient of the Goyal Prize in 2003, Basu was awarded the civilian honour ofPadma Shri by theGovernment of India in 2001.

See also

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References

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  1. ^abcdefghijkl"INSA". INSA. 2014. Archived from the original on 12 August 2016. Retrieved5 January 2015.
  2. ^"Padma Awards"(PDF). Padma Awards. 2014. Archived fromthe original(PDF) on 15 October 2015. Retrieved11 November 2014.
  3. ^"ResearchGate". 2014. Retrieved5 January 2015.
  4. ^"NISCAIR". NISCAIR. 2014. Retrieved5 January 2015.
  5. ^"Microsoft Academic Search". Microsoft Academic Search. 2014. Retrieved5 January 2015.
  6. ^"PubFacts". PubFacts. 2014. Retrieved5 January 2015.
  7. ^Michael S Brown; Sandip K Basu; JR Falck; YK Ho; Joseph L Goldstein (1980). "The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages".Journal of Supramolecular Structure.13 (1):67–81.doi:10.1002/jss.400130107.PMID 6255257.
  8. ^Goldstein, J. L.; Ho, Y. K.; Basu, S. K.; Brown, M. S. (1979)."Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition".Proceedings of the National Academy of Sciences.76 (1):333–337.Bibcode:1979PNAS...76..333G.doi:10.1073/pnas.76.1.333.PMC 382933.PMID 218198.
  9. ^Goldstein JL; Basu SK; Brunschede GY; Brown MS (January 1976). "Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans".Cell.7 (1):85–95.doi:10.1016/0092-8674(76)90258-0.PMID 181140.S2CID 23110979.
  10. ^"Google Scholar". Google Scholar. 2014. Retrieved5 January 2015.
  11. ^"IAS". IAS. 2014. Retrieved5 January 2015.
  12. ^"TWAS". TWAS. 2014. Retrieved5 January 2015.
  13. ^"NII". NII. 2014. Retrieved5 January 2015.

External links

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  • Goldstein JL; Basu SK; Brunschede GY; Brown MS (January 1976). "Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans".Cell.7 (1):85–95.doi:10.1016/0092-8674(76)90258-0.PMID 181140.S2CID 23110979.
  • Michael S Brown; Sandip K Basu; JR Falck; YK Ho; Joseph L Goldstein (1980). "The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages".Journal of Supramolecular Structure.13 (1):67–81.doi:10.1002/jss.400130107.PMID 6255257.
2000s recipients of thePadma Shri in science and engineering
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