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Samuel Karlin

From Wikipedia, the free encyclopedia
Polish American mathematician
Samuel Karlin
Born(1924-06-08)June 8, 1924
DiedDecember 18, 2007(2007-12-18) (aged 83)
CitizenshipAmerican
Alma materIllinois Institute of Technology
Princeton University
Known forBLAST
Karlin-Rubin theorem (UMP tests ofmonotonelikelihoods)
geometry ofmoments[2]
Total positivity
Tchebycheff systems
Optimal experiments
AwardsNational Medal of Science (1989)
John von Neumann Theory Prize (1987)
Scientific career
Fieldsmathematical sciences
population genetics
InstitutionsStanford University
Doctoral advisorSalomon Bochner
Doctoral studentsChristopher Burge[1]
Thomas Liggett
Charles A. Micchelli
John W. Pratt
Stephen M. Samuels
Charles Joel Stone
Rupert G. Miller
Marcel F. Neuts

Samuel Karlin (June 8, 1924 – December 18, 2007) was an American mathematician atStanford University in the late 20th century.

Education and career

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Karlin was born in Janów,Poland and immigrated toChicago as a child. Raised in anOrthodoxJewish household, Karlin became an atheist in his teenage years and remained an atheist for the rest of his life. Later in life he told his three children, who all became scientists, that walking down the street without a yarmulke on his head for the first time was a milestone in his life.[3]

Karlin earned his undergraduate degree fromIllinois Institute of Technology; and then his doctorate in mathematics fromPrinceton University in 1947 (at the age of 22) under the supervision ofSalomon Bochner. He was on the faculty ofCaltech from 1948 to 1956, before becoming a professor of mathematics and statistics atStanford.[3][4]

Throughout his career, Karlin made fundamental contributions to the fields of mathematical economics,bioinformatics, game theory, evolutionary theory, biomolecular sequence analysis, andtotal positivity.[4] Karlin authored ten books and more than 450 articles. He did extensive work inmathematical population genetics. In the early 1990s, Karlin andStephen Altschul developed the Karlin-Altschul statistics, a basis for the highly used sequence similarity software programBLAST.[3]

Honors and awards

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Karlin was a member of theAmerican Academy of Arts and Sciences,[5] theNational Academy of Sciences,[6] and theAmerican Philosophical Society.[7] He won aLester R. Ford Award in 1973.[8] In 1989, PresidentGeorge H. W. Bush bestowed Karlin theNational Medal of Science "for his broad and remarkable research in mathematical analysis, probability theory and mathematical statistics, and in the application of these ideas to mathematical economics, mechanics, and population genetics."[9] He was elected to the 2002 class ofFellows of theInstitute for Operations Research and the Management Sciences.[10]

Personal life

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One of Karlin's sons,Kenneth D. Karlin, is a professor ofchemistry atJohns Hopkins University and the 2009 winner of theAmerican Chemical Society'sF. Albert Cotton Award for Synthetic Chemistry.[11] His other son, Manuel, is a physician inPortland, Oregon. His daughter,Anna R. Karlin, is a theoretical computer scientist, the Microsoft Professor of Computer Science & Engineering at theUniversity of Washington.[12]

Selected publications

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See also

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References

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  1. ^Burge, Christopher;Karlin, Samuel (1997)."Prediction of complete gene structures in human genomic DNA"(PDF).Journal of Molecular Biology.268 (1):78–94.CiteSeerX 10.1.1.115.3107.doi:10.1006/jmbi.1997.0951.PMID 9149143. Archived fromthe original(PDF) on 2015-06-20.
  2. ^Artstein, Zvi (1980). "Discrete and continuous bang-bang and facial spaces, or: Look for the extreme points".SIAM Review.22 (2):172–185.doi:10.1137/1022026.JSTOR 2029960.MR 0564562.
  3. ^abcDan Stober (January 16, 2008)."Sam Karlin, mathematician who improved DNA analysis, dead at 83".Stanford.edu. Archived fromthe original on June 12, 2016. RetrievedJuly 16, 2019.
  4. ^abSam Karlin, influential math professor, dead at 83Archived 2008-05-12 at theWayback Machine
  5. ^"Samuel Karlin".American Academy of Arts & Sciences. Retrieved2021-12-21.
  6. ^"Samuel Karlin".www.nasonline.org. Retrieved2021-12-21.
  7. ^"APS Member History".search.amphilsoc.org. Retrieved2021-12-21.
  8. ^Karlin, Samuel (1972)."Some mathematical models of population genetics".Amer. Math. Monthly.79 (7):699–739.doi:10.2307/2316262.JSTOR 2316262.
  9. ^US NSF - The President's National Medal of Science: Recipient Details
  10. ^Fellows: Alphabetical List,Institute for Operations Research and the Management Sciences, retrieved2019-10-09
  11. ^Kenneth Karlin's web site at JHU, retrieved 2011-01-16.
  12. ^Anna Karlin's faculty web page at U. Washington, retrieved 2011-01-16.

External links

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