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Samalizumab

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Monoclonal antibody

Pharmaceutical compound

Samalizumab
Monoclonal antibody
Type	Whole antibody
Source	Humanized (frommouse)
Target	CD200
Clinical data
ATC code	none
Identifiers
CAS Number	1073059-33-2^N
ChemSpider	none
UNII	64EUX713G6
KEGG	D09961^N
Chemical and physical data
Formula	C₆₅₄₂H₁₀₀₈₆N₁₇₀₂O₂₁₀₂S₄₆
Molar mass	147687.22 g·mol⁻¹
^NY (what is this?) (verify)

Samalizumab is a humanized monoclonal antibody designed for oncology indications.^[1] Samalizumab is a recombinant humanized monoclonal antibody that targets the immunoregulatory proteinCD200. Results from a Phase I study indicated the drug has potential for use in treating cancers including chronic lymphocytic leukemia.^[2]

Samalizumab was developed byAlexion Pharmaceuticals.^[3]

References

[edit]

^"Statement On A Nonproprietary Name Adopted By The USAN Council: Samalizumab"(PDF).American Medical Association.
^Mahadevan D, Lanasa MC, Farber C, Pandey M, Whelden M, Faas SJ, et al. (August 2019)."Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200".Journal for Immunotherapy of Cancer.7 (1): 227.doi:10.1186/s40425-019-0710-1.hdl:10150/634601.PMC 6708181.PMID 31443741.
^"Samalizumab Overview - Creative Biolabs".www.creativebiolabs.net. Retrieved2025-08-21.

Monoclonal antibodies for theimmune system

Immune system

Human	Immunosuppression:Abrilumab Adalimumab^# Anifrolumab Atorolimumab Avelumab Avdoralimab Belimumab Bleselumab Brodalumab Camidanlumab tesirine Carlumab Cemiplimab Dupilumab Eldelumab Emapalumab Fresolimumab Garadacimab Golimumab Ianalumab^† Lanadelumab Lenzilumab Lerdelimumab Lirentelimab Lirilumab Mavrilimumab Metelimumab Morolimumab Namilumab Nipocalimab Oleclumab Oxelumab§ Pamrevlumab Placulumab Relatlimab^† Sarilumab Sifalimumab Tabalumab Tezepelumab Ulocuplumab Varlilumab Immune activation:Ipilimumab Durvalumab Nivolumab Tremelimumab Urelumab Other:Bertilimumab Ontamalimab Zanolimumab Combination:Nivolumab/relatlimab
Mouse	Afelimomab Elsilimomab Faralimomab Gavilimomab Inolimomab Maslimomab Nerelimomab Odulimomab Telimomab aritox Vepalimomab Zolimomab aritox
Chimeric	Andecaliximab^† Basiliximab Clenoliximab Galiximab Gomiliximab Infliximab Keliximab Lumiliximab Priliximab Teneliximab Vapaliximab
Humanized	Immunosuppressive:Apolizumab^§ Aselizumab Atezolizumab Benralizumab Camrelizumab^† Cedelizumab Certolizumab pegol Crizanlizumab Daclizumab Eculizumab Efalizumab^‡ Epratuzumab Erlizumab Etrolizumab^† Fontolizumab Frexalimab^† Inebilizumab Itolizumab Lampalizumab^† Letolizumab Ligelizumab^† Lulizumab pegol Mepolizumab Mogamulizumab Natalizumab Ocrelizumab (+hyaluronidase) Omalizumab Ozoralizumab Pascolizumab Pateclizumab Pembrolizumab (+berahyaluronidase alfa) Pexelizumab Pidilizumab Plozalizumab PRO 140^† Quilizumab Ravulizumab Reslizumab Retifanlimab Rontalizumab Rovelizumab Ruplizumab Samalizumab Satralizumab Siplizumab Spartalizumab^† Talizumab Teclistamab Teplizumab Tislelizumab Tocilizumab Toralizumab Tregalizumab Vatelizumab Vedolizumab Visilizumab Vobarilizumab TGN1412^§ Immune activation:Dostarlimab Other:Ibalizumab
Chimeric + humanized	Otelixizumab Rozanolixizumab Sutimlimab

Interleukin

Human	Bermekimab Brazikumab Briakinumab Canakinumab Fezakinumab Fletikumab Guselkumab Secukinumab Sirukumab Tralokinumab Ustekinumab
Humanized	Anrukinzumab Bimekizumab Clazakizumab Gevokizumab Ixekizumab Mirikizumab^† Lebrikizumab Olokizumab^† Perakizumab Risankizumab Spesolimab Tildrakizumab
Veterinary	Lokivetmab

Inflammatorylesions

Mouse	Besilesomab Fanolesomab^‡ Lemalesomab Sulesomab

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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