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| Formula | C23H30O8 |
| Molar mass | 434.485 g·mol−1 |
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Salvinorin B methoxymethyl ether (2-O-methoxymethylsalvinorin B) is a semi-syntheticanalogue of the natural productsalvinorin A used in scientific research.[1][2] It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A,[3] and has increased affinity and potency at theκ-opioidreceptor. It is prepared fromsalvinorin B.[4] Thecrystal structure is almost superimposable with that of salvinorin A.[5] Structures bound to the κ-opioid receptor have also been reported.[6]
Salvinorin B methoxymethyl ether has aKi of 0.60 nM at the κ opioid receptor,[7] and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its ethoxymethyl etherhomolog, 'symmetry'.[7][8][9]
