Sir Salvador Moncada | |
|---|---|
 Moncada in 2022 | |
| Born | (1944-12-03)3 December 1944 (age 80) |
| Other names | Salvador Enrique Moncada Seidner |
| Citizenship | United Kingdom Honduras |
| Alma mater | |
| Known for | Prostacyclin |
| Spouses |
|
| Children | 4 |
| Awards | |
| Scientific career | |
| Fields | Pharmacology |
| Institutions | |
| Website | manchester |
Sir Salvador Enrique Moncada Seidner (born 3 December 1944) is a Honduran-Britishpharmacologist and professor. He is currently Research Domain Director for Cancer at theUniversity of Manchester.[3]
In the past, he was the Research Director of the Wellcome Research Laboratories from 1986 to 1995 and, until recently, the Director of theUCL Wolfson Institute, which he established atUniversity College London in 1996. His research interests include inflammation and vascular biology and he is currently working on the regulation of cell proliferation. He gained fame for his discoveries related tonitric oxide function and metabolism, and his exclusion from the 1996Lasker Award and the 1998Nobel Prize in medicine.[4][5][6][7][8][9][10]
Sir Salvador was nominated byXiomara Castro, the President of Honduras, to serve as their first Ambassador toChina following the Honduran government's recognition of the People's Republic of China in March 2023. The Embassy in Beijing was opened in June 2023.[11]
Moncada was born inTegucigalpa,Honduras, to Salvador Moncada and Jenny Seidner on 3 December 1944, and moved toEl Salvador in 1948. He attended the secondary School Instituto Nacional inSan Salvador (El Salvador) between 1957 and 1961. In 1962, he went to study medicine at theUniversity of El Salvador where he received anMD degree in 1970. In 1971 he went toLondon to work on a research doctorate withJohn Vane at the Department of Pharmacology of the Institute of Basic Medical Sciences,Royal College of Surgeons. In 1974, Moncada obtained aPhD in Pharmacology from theUniversity of London. After a short period of research at theNational Autonomous University of Honduras between 1974 and 1975, he moved to theWellcome Research Laboratories (Beckenham, Kent), where he became director of research in 1986. During this period he also received a higherDSc degree from the University of London in 1983. In 1996, Moncada moved to this university, where he was director of theUCL Wolfson Institute (formerly known as The Cruciform Project for Strategic Medical Research) until 2011 and a professor of experimental biology and therapeutics until 2013.[2][12]
His scientific career began at the Royal College of Surgeons, where he collaborated in the discovery that aspirin-like drugs inhibitprostaglandin biosynthesis. This finding elucidated the mechanism by which these drugs act asanalgesic,antipyretic, and anti-inflammatory agents and also explained the mechanism by which they cause gastric damage. In 1975, at the Wellcome Research Laboratories, he led the team that discovered the enzymethromboxane synthase and thevasodilatorprostacyclin. This work contributed to the understanding of how low doses of aspirin prevent cardiovascular episodes such asmyocardial infarction and stroke. As director of research at the Wellcome Research Laboratories he presided over the discovery and development oflamotrigine (an anti-epileptic compound),atovaquone (an anti-malarial) andzomig (for treatment of migraine headaches), and initiated the work that resulted in the development oflapatinib for the treatment of breast cancer. He was also responsible for the identification ofnitric oxide as a biological mediator and the elucidation of the metabolic pathway leading to its synthesis. A great deal of the early work on the biological significance of nitric oxide in the cardiovascular system came from his laboratory, as well as some fundamental information about the role of nitric oxide in theperipheral andcentral nervous systems and in cancer. His later work has focused on the areas of mitochondrial biology and cell metabolism. Most recently, his work has led to the finding of the molecular mechanism that coordinates cell proliferation with the provision of metabolic substrates required for this process.
Moncada is the author of more than 500 peer-reviewed papers and highly cited reviews, including
Moncada is interested in medical education and in the development of science and technology in Latin America. He has been a consultant of thePanamerican Health Organization (PAHO, the regional office of the WHO) and in recent years he founded Honduras Global – an international network of experts involved in supporting the development of Honduras.
Moncada is an elected member of a number of international scientific societies. Foreign Member of theNational Academy of Sciences of the United States of America (1994); Fellow of theRoyal College of Physicians, London (1994), and Honorary Fellow ofUniversity College, London (1999). He was elected aFellow of the Royal Society (FRS) in 1988.[13]
He has received honorary degrees from more than twenty universities, including Honorary Degree of Doctor of Science,Mount Sinai School of Medicine, New York City (1995); Degree of Doctor "Honoris Causa" of theUniversity Pierre & Marie Curie, Paris, France (1997) and Honorary Degree of Doctor of Science of theUniversity of Edinburgh, Scotland (2000).
His prizes and distinguished lectures include: The VIII Gaddum Memorial Lecture,British Pharmacological Society (1980); ThePrince of Asturias Award (1990);[14] The Ulf von Euler Memorial Lecture, Karolinska Institute, Stockholm, Sweden (1991); The Paul Dudley White Lecture,American Heart Association, Anaheim, California, USA (1991); TheRoyal Medal of theRoyal Society, UK (1994); TheGregory Pincus Memorial Lecture, theWorcester Foundation for Biomedical Research, Massachusetts, USA (1996); The Louis and Artur Lucian Award (jointly with Prof. R. Furchgott), McGill University, Montreal, Canada (1997); The Bayliss-Starling Prize Lecture to thePhysiological Society, UK (2000); The Gold Medal of theRoyal Society of Medicine, UK (2000);Le Grand Prix Annuel Lefoulon-Delalande, from theInstitut de France, Paris (2002); theCroonian Lecture at the Royal Society, London, UK (2005), theDebrecen Award for Molecular Medicine from theUniversity of Debrecen, Hungary (2011)[15] and The Dohme Lecture, TheJohns Hopkins University School of Medicine, Baltimore (2010).
In the2010 New Year Honours, Moncada wasknighted for Services to Science by QueenElizabeth II.[16] In 2013 he was awarded the Ernst Jung Gold Medal for Medicine (Ernst Jung Prize).
He was married to Dorys Lemus, abiochemistry teacher at the Medical School in El Salvador. The marriage resulted in two children, Claudia Regina (born 1966 – aG.P. who lives in London) and Salvador Ernesto (1972–1982). On 5 April 1998, in London, he marriedPrincess Marie-Esméralda of Belgium. They have two children, Alexandra Leopoldine (born in London on 4 August 1998) and Leopoldo Daniel (born in London on 21 May 2001), and two grandchildren.
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