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SYT4

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SYT4
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1UGK

Identifiers
AliasesSYT4, HsT1192, synaptotagmin 4
External IDsOMIM:600103;MGI:101759;HomoloGene:7559;GeneCards:SYT4;OMA:SYT4 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for SYT4
Genomic location for SYT4
Band18q12.3Start43,267,892bp[1]
End43,277,535bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for SYT4
Genomic location for SYT4
Band18 B1|18 17.75 cMStart31,570,861bp[2]
End31,580,459bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • endothelial cell

  • cerebellar hemisphere

  • Brodmann area 23

  • right hemisphere of cerebellum

  • Brodmann area 46

  • middle temporal gyrus

  • superior frontal gyrus

  • superior vestibular nucleus

  • islet of Langerhans
Top expressed in
  • lobe of cerebellum

  • cerebellar vermis

  • ventral tegmental area

  • pineal gland

  • dorsomedial hypothalamic nucleus

  • habenula

  • anterior amygdaloid area

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus

  • lateral hypothalamus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6860

20983

Ensembl

ENSG00000132872

ENSMUSG00000024261

UniProt

Q9H2B2

P40749

RefSeq (mRNA)

NM_020783

NM_009308

RefSeq (protein)

NP_065834

NP_033334

Location (UCSC)Chr 18: 43.27 – 43.28 MbChr 18: 31.57 – 31.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-4 is aprotein that in humans is encoded by theSYT4gene.[5][6]


References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000132872 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024261 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Hilbush BS, Morgan JI (Sep 1994)."A third synaptotagmin gene, Syt3, in the mouse".Proc Natl Acad Sci U S A.91 (17):8195–9.Bibcode:1994PNAS...91.8195H.doi:10.1073/pnas.91.17.8195.PMC 44572.PMID 8058779.
  6. ^"Entrez Gene: SYT4 synaptotagmin IV".

Further reading

[edit]

External links

[edit]
  • Overview of all the structural information available in thePDB forUniProt:Q9H2B2 (Human Synaptotagmin-4) at thePDBe-KB.
PDB gallery
  • 1ugk: Solution structure of the first C2 domain of synaptotagmin IV from human fetal brain (KIAA1342)
    1ugk: Solution structure of the first C2 domain of synaptotagmin IV from human fetal brain (KIAA1342)
  • 1w15: RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE PRESENCE OF CALCIUM
    1w15: RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE PRESENCE OF CALCIUM
  • 1w16: RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE ABSENCE OF CALCIUM
    1w16: RAT SYNAPTOTAGMIN 4 C2B DOMAIN IN THE ABSENCE OF CALCIUM
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPI
COPII
RME/Clathrin
Caveolae
Other/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other


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