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SX-3228

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
SX-3228
Clinical data
Other names5,6,7,8-tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)-6-(phenylmethyl)-1,6-naphthyridin-2(1H)-one
Identifiers
  • (3E)-6-benzyl-3-(5-methoxy-1,3,4-oxadiazol-2(3H)-ylidene)-5,6,7,8-tetrahydro-1,6-naphthyridin-2(3H)-one
CAS Number
PubChemCID
ChemSpider
UNII
Chemical and physical data
FormulaC18H18N4O3
Molar mass338.367 g·mol−1
3D model (JSmol)
  • COc1nnc(o1)C/3=C/C=4CN(Cc2ccccc2)CCC=4NC\3=O
  • InChI=1S/C18H18N4O3/c1-24-18-21-20-17(25-18)14-9-13-11-22(8-7-15(13)19-16(14)23)10-12-5-3-2-4-6-12/h2-6,9H,7-8,10-11H2,1H3,(H,19,23) checkY
  • Key:BZLLVTYOOJNQIF-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

SX-3228 is asedative andhypnotic drug used in scientific research. It has similar effects to sedative-hypnoticbenzodiazepine drugs, but is structurally distinct and so is classed as anonbenzodiazepine hypnotic.

SX-3228 is a subtype-selectiveGABAApositive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such aszolpidem andzaleplon in animal studies.[1][2] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limitedanxiolytic effects which appear only at doses that also produce significant sedation.[3][4]

References

[edit]
  1. ^Sanger DJ (August 1997). "The effects of new hypnotic drugs in rats trained to discriminate ethanol".Behavioural Pharmacology.8 (4):287–92.doi:10.1097/00008877-199708000-00002.PMID 9832988.S2CID 42758930.
  2. ^Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ (September 1999). "Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands".Behavioural Pharmacology.10 (5):483–95.doi:10.1097/00008877-199909000-00007.PMID 10780255.
  3. ^Griebel G, Perrault G, Sanger DJ (1998). "Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents".Journal of Psychopharmacology.12 (4):356–65.doi:10.1177/026988119801200405.PMID 10065909.S2CID 269304.
  4. ^Alvariño F, Monti JM, Jantos H, Monti D (August 1999)."Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat".Brazilian Journal of Medical and Biological Research.32 (8):1007–14.doi:10.1590/s0100-879x1999000800011.PMID 10454763.
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