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Bile salt sulfotransferase

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From Wikipedia, the free encyclopedia

(Redirected fromSULT2A1)

Protein-coding gene in the species Homo sapiens

SULT2A1

Available structures

PDB

Human UniProt search:PDBe RCSB

List of PDB id codes
1EFH,1J99,1OV4,2QP3,2QP4,3F3Y,4IFB

Identifiers

Aliases

SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3

External IDs

OMIM:125263;MGI:3645854;HomoloGene:37741;GeneCards:SULT2A1;OMA:SULT2A1 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	47,870,467bp^[1]
Band	19q13.33	End	47,886,315bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 A1	Start	13,643,601bp^[2]
Band	7\|7 A1	End	13,723,532bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right adrenal cortex

jejunal mucosa

right lobe of liver

left adrenal cortex

duodenum

gonad

buccal mucosa cell

seminal vesicula

cardia

mucosa of ileum

Top expressed in

primary oocyte

zygote

secondary oocyte

spermatocyte

spermatid

gonad

testicle

liver

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity sulfotransferase activity protein binding estrone sulfotransferase activity aryl sulfotransferase activity steroid sulfotransferase activity bile-salt sulfotransferase activity
Cellular component	cytoplasm cytosol
Biological process	lipid catabolic process bile acid catabolic process sulfation lipid metabolism ethanol catabolic process regulation of lipid metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process steroid metabolic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


6822


434121

Ensembl


ENSG00000105398


ENSMUSG00000074377

UniProt


Q06520


n/a

RefSeq (mRNA)


NM_003167


NM_001101534

RefSeq (protein)


NP_003158


n/a

Location (UCSC)

Chr 19: 47.87 – 47.89 Mb

Chr 7: 13.64 – 13.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Bile salt sulfotransferase also known ashydroxysteroid sulfotransferase (HST) orsulfotransferase 2A1 (ST2A1) is anenzyme that in humans is encoded by theSULT2A1gene.^[5]^[6]^[7]

Function

[edit]

Sulfotransferase enzymes catalyze thesulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000105398 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000074377 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".
^Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992)."Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA".Mol. Pharmacol.41 (5):865–72.doi:10.1016/S0026-895X(25)09136-9.PMID 1588921.
^Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995)."Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3".Cytogenet. Cell Genet.70 (1–2):45–7.doi:10.1159/000133988.PMID 7736787.

External links

[edit]

alcohol+sulfotransferase at the U.S. National Library of MedicineMedical Subject Headings (MeSH)
HumanSULT2A1 genome location andSULT2A1 gene details page in theUCSC Genome Browser.

v t e PDB gallery
1efh: CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP 1j99: CRYSTAL STRUCTURE OF HUMAN DEHYDROEPIANDROSTERONE SULFOTRANSFERASE IN COMPLEX WITH SUBSTRATE 1ov4: Crystal structure of human DHEA-ST complexed with androsterone

v t e Transferases:sulfur-containing group (EC 2.8)
2.8.1:Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase lipoyl synthase molybdenum cofactor sulfurtransferase thiazole synthase molybdopterin synthase sulfurtransferase molybdopterin synthase tRNA-uridine 2-sulfurtransferase () tRNA-5-taurinomethyluridine 2-sulfurtransferase () tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase () L-aspartate semialdehyde sulfurtransferase ()
2.8.2:Sulfotransferases	aryl sulfotransferase amine sulfotransferase estrone sulfotransferase chondroitin 4-sulfotransferase choline sulfotransferase UDP-N-acetylgalactosamine-4-sulfate sulfotransferase heparan sulfate-glucosamine N-sulfotransferase tyrosine-ester sulfotransferase Renilla-luciferin sulfotransferase galactosylceramide sulfotransferase psychosine sulfotransferase bile salt sulfotransferase steroid sulfotransferase thiol sulfotransferase chondroitin 6-sulfotransferase cortisol sulfotransferase triglucosylalkylacylglycerol sulfotransferase protein-tyrosine sulfotransferase keratan sulfotransferase aryl-sulfate sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 1 desulfoglucosinolate sulfotransferase flavonol 3-sulfotransferase quercetin-3-sulfate 3′-sulfotransferase quercetin-3-sulfate 4′-sulfotransferase quercetin-3,3′-bissulfate 7-sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 2 (heparan sulfate)-glucosamine 3-sulfotransferase 3 petromyzonol sulfotransferase scymnol sulfotransferase N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase glycochenodeoxycholate sulfotransferase dermatan 4-sulfotransferase desulfo-A47934 sulfotransferase () trehalose 2-sulfotransferase () aliphatic desulfoglucosinolate sulfotransferase () hydroxyjasmonate sulfotransferase () ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*) Alcohol sulfotransferase Tyrosylprotein sulfotransferase
2.8.3:CoA-transferases	Propionate CoA-transferase oxalate CoA-transferase malonate CoA-transferase 3-oxoacid CoA-transferase 3-oxoadipate CoA-transferase succinyl-CoA—Dcitramalate CoA-transferase acetate CoA-transferase butyrate—acetoacetate CoA-transferase citrate CoA-transferase citramalate CoA-transferase glutaconate CoA-transferase succinate—hydroxymethylglutarate CoA-transferase 5-hydroxypentanoate CoA-transferase succinyl-CoA:(R)-benzylsuccinate CoA-transferase formyl-CoA transferase cinnamoyl-CoA:phenyllactate CoA-transferase succinyl-CoA:acetate CoA-transferase () CoA:oxalate CoA-transferase () succinyl-CoA—D-citramalate CoA-transferase () L-carnitine CoA-transferase () succinyl-CoA—L-malate CoA-transferase () caffeate CoA-transferase () (R)-2-hydroxy-4-methylpentanoate CoA-transferase () bile acid CoA-transferase () succinyl-CoA:mesaconate CoA transferase (*)
2.8.4: Alkylthio	2.8.4: Coenzyme-B sulfoethylthiotransferase arsenate-mycothiol transferase tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase () [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase () tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase (*)
2.8.5:	2.8.5: S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) () L-cysteineS-thiosulfotransferase ()