ZNF280D
Identifiers
Aliases	ZNF280D, SUHW4, ZNF634, zinc finger protein 280D
External IDs	MGI:2384583;HomoloGene:17151;GeneCards:ZNF280D;OMA:ZNF280D - orthologs
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9|9 D Start 72,182,142bp[1] End 72,271,059bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in genital tubercle tail of embryo zygote thymus Rostral migratory stream pineal gland ganglionic eminence secondary oocyte superior cervical ganglion anterior amygdaloid area BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 54816 235469 Ensembl ENSG00000137871 ENSMUSG00000038535 UniProt Q6N043 Q68FE8 RefSeq (mRNA) NM_001002843 NM_001002844 NM_001288588 NM_001288589 NM_017661 NM_146224 NM_001311105 RefSeq (protein) NP_001002843 NP_001002844 NP_001275517 NP_001275518 NP_060131 NP_001298034 NP_666336 Location (UCSC) n/a Chr 9: 72.18 – 72.27 Mb PubMed search [2] [3]
Wikidata
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Zinc finger protein 280D, also known as Suppressor Of Hairy Wing Homolog 4, SUWH4, Zinc Finger Protein 634, ZNF634, or KIAA1584, is aprotein that in humans is encoded by theZNF280Dgene located on chromosome 15q21.3.^[4][5]

There are a total of 24 possibleexons in any variant of the ZNF280D gene.^[6] ZNF280D is oriented on the minus strand ofChromosome 15 and spans 288.396 kb.^[7]Surrounding genes at the same locus includeTEX9,HMGB1P33,MNS1,LOC645877, andLOC145783.^[8]

At least 24 spliced variants have been identified.^[9] There are 7 probable alternativepromoters. The mRNAs appear to differ by truncation of the5' end, truncation of the3' end, presence or absence of 12 cassette exons, overlapping exons with different boundaries, splicing versus retention of 5introns.^[9] The longest splice form contains 4428 bp.^[10]

The ZNF280D protein is 979amino acids in length.^[11]The protein contains adomain of unknown function (DUF4195) spanning from amino acid 45 to amino acid 230.^[11]DUF4195 (pfam13826) is a family that is found at theN-terminus ofmetazoan proteins that carry PHD-likezinc-finger domains; the function is unknown.^[12]ZNF280D protein also contains five highly conserved Cys2His2-typezinc finger domains.^[13]Zinc fingers have the ability to bind DNA, which supports the speculative role of ZNF280D as atranscription factor.^[14]The protein has a weight of approximately 109.3 kdal.^[15]Charge cluster analysis reveals a negative charge cluster near the N-terminus from amino acids 16-43.^[15]Charge clusters are associated with functional domains of cellular transcription factors, providing further support for ZNF280D as a possible transcription factor.^[16]

ZNF280D has been experimentally determined to interact withCBX5 andCBX3 proteins.^[17]These proteins both play a role in the formation ofheterochromatin, which presents a possible functional role of ZNF280D as a transcriptionalrepressor.^[18][19]

There are a number ofSNPs that have been observed in the human population.^[20] The image below lists some of the most frequently occurring.

A number oftranscription factors are predicted to bind to the predicted promoter region.^[21]

ZNF280D protein contains 66 serine, 17 threonine, and 6 tyrosine residues all of which are potentialphosphorylation sites.^[22]

The glycine residue at position 2 is a probable candidate for N-terminalacetylation.^[23]There are seven probablesumoylation sites.^[24]

ZNF280D isubiquitously expressed at relatively low levels throughout almost all tissues in the human body.^[25]

In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. The results show that expression was significantly higher in cord blood. This supports a possible involvement of ZNF280D in embryonic development or cell differentiation.^[26]

A number oforthologs and distanthomologs have been identified for the human ZNF280D protein. There are also fourparalogs to ZNF280D in the human genome.^[27]

• Human genes

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