Movatterモバイル変換

[0]ホーム

Jump to content

STX16

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

STX16

Identifiers

Aliases

STX16, SYN16, syntaxin 16, SYN-16

External IDs

OMIM:603666;MGI:1923396;HomoloGene:2791;GeneCards:STX16;OMA:STX16 - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.32	Start	58,651,253bp^[1]
Band	20q13.32	End	58,679,526bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 H4	Start	173,918,101bp^[2]
Band	2\|2 H4	End	173,941,564bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

sural nerve

corpus callosum

superficial temporal artery

pituitary gland

right hemisphere of cerebellum

body of uterus

C1 segment

right ovary

anterior pituitary

Top expressed in

hand

neural layer of retina

otolith organ

utricle

thymus

lens

cerebellar cortex

primary visual cortex

yolk sac

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	SNAP receptor activity protein binding syntaxin binding SNARE binding
Cellular component	cytoplasm integral component of membrane Golgi apparatus membrane intracellular membrane-bounded organelle Golgi cisterna focal adhesion trans-Golgi network SNARE complex endoplasmic reticulum perinuclear region of cytoplasm cytosol trans-Golgi network membrane Golgi membrane endomembrane system integral component of synaptic vesicle membrane
Biological process	vesicle docking retrograde transport, endosome to Golgi protein transport intracellular protein transport vesicle fusion Golgi ribbon formation vesicle-mediated transport transport
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


8675


228960

Ensembl


ENSG00000124222


ENSMUSG00000027522

UniProt


O14662


Q8BVI5

RefSeq (mRNA)

NM_001001433 NM_001001434 NM_001134772 NM_001134773 NM_001204868
NM_003763

NM_001102423 NM_001102424 NM_001102425 NM_172675 NM_001363029
NM_001363030 NM_001363031

RefSeq (protein)


NP_001001433 NP_001128244 NP_001128245 NP_001191797 NP_003754

NP_001095893 NP_001095894 NP_001095895 NP_766263 NP_001349958
NP_001349959 NP_001349960

Location (UCSC)

Chr 20: 58.65 – 58.68 Mb

Chr 2: 173.92 – 173.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Syntaxin-16 is aprotein that in humans is encoded by theSTX16gene.^[5]^[6]^[7]^[8]

It has been associated withpseudohypoparathyroidism type Ib. Losing this gene causes loss of methylation atGNAS1 exon A/B.^[7]

Interactions

[edit]

STX16 has been shown tointeract withVAMP4.^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000124222 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000027522 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tang BL, Low DY, Lee SS, Tan AE, Hong W (January 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins".Biochemical and Biophysical Research Communications.242 (3):673–679.Bibcode:1998BBRC..242..673T.doi:10.1006/bbrc.1997.8029.PMID 9464276.
^Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (March 1998). "Syntaxin-16, a putative Golgi t-SNARE".European Journal of Cell Biology.75 (3):223–231.doi:10.1016/S0171-9335(98)80116-7.PMID 9587053.
^^a ^bLinglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005)."A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS".American Journal of Human Genetics.76 (5):804–814.doi:10.1086/429932.PMC 1199370.PMID 15800843.
^"Entrez Gene: STX16 syntaxin 16".
^Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, et al. (February 2002)."Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform".The Journal of Cell Biology.156 (4):653–664.doi:10.1083/jcb.200110081.PMC 2174079.PMID 11839770.

Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, et al. (August 2001)."Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs".Genome Research.11 (8):1392–1403.doi:10.1101/gr.175501.PMC 311073.PMID 11483580.
Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, et al. (February 2002)."Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform".The Journal of Cell Biology.156 (4):653–664.doi:10.1083/jcb.200110081.PMC 2174079.PMID 11839770.
Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, et al. (July 2002)."How Tlg2p/syntaxin 16 'snares' Vps45".The EMBO Journal.21 (14):3620–3631.doi:10.1093/emboj/cdf381.PMC 126126.PMID 12110575.
Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, et al. (December 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios".Science.302 (5652):1960–1963.Bibcode:2003Sci...302.1960C.doi:10.1126/science.1088821.PMID 14671302.S2CID 6682593.
Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, et al. (September 2004)."Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network".Molecular Biology of the Cell.15 (9):4011–4022.doi:10.1091/mbc.E03-12-0876.PMC 515336.PMID 15215310.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004)."Functional proteomics mapping of a human signaling pathway".Genome Research.14 (7):1324–1332.doi:10.1101/gr.2334104.PMC 442148.PMID 15231748.
Amessou M, Fradagrada A, Falguières T, Lord JM, Smith DC, Roberts LM, et al. (April 2007)."Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins".Journal of Cell Science.120 (Pt 8):1457–1468.doi:10.1242/jcs.03436.PMC 1863825.PMID 17389686.

Membrane protein:vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18:STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP:VAMP1 VAMP2 VAMP3

Synaptotagmin

Other

Small GTPase:RAB3A

COPI

Coatomer

Small GTPase:ARF

COPII

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase:SAR1A

RME/Clathrin

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47