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SSH3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SSH3

Identifiers

Aliases

SSH3, SSH3L, slingshot protein phosphatase 3

External IDs

OMIM:606780;MGI:2683546;HomoloGene:32372;GeneCards:SSH3;OMA:SSH3 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.2	Start	67,303,478bp^[1]
Band	11q13.2	End	67,312,607bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 A	Start	4,311,696bp^[2]
Band	19\|19 A	End	4,319,208bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

right hemisphere of cerebellum

minor salivary glands

right uterine tube

mucosa of transverse colon

vagina

skin of leg

ectocervix

skin of abdomen

gastric mucosa

Top expressed in

granulocyte

esophagus

primary visual cortex

superior frontal gyrus

cerebellar cortex

stomach

colon

neural layer of retina

duodenum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein tyrosine phosphatase activity phosphatase activity actin binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity
Cellular component	cytoplasm cytoskeleton nucleus
Biological process	regulation of lamellipodium assembly regulation of axonogenesis regulation of actin polymerization or depolymerization protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation cell morphogenesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


54961


245857

Ensembl


ENSG00000172830


ENSMUSG00000034616

UniProt


Q8TE77


Q8K330

RefSeq (mRNA)


NM_017857 NM_018276


NM_198113 NM_001356620 NM_001374687

RefSeq (protein)


NP_060327


NP_932781 NP_001343549

Location (UCSC)

Chr 11: 67.3 – 67.31 Mb

Chr 19: 4.31 – 4.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein phosphatase Slingshot homolog 3 is anenzyme that in humans is encoded by theSSH3gene.^[5]^[6]

Function

[edit]

TheADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators ofactin dynamics. ADF/cofilinproteins are inactivated bykinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000172830 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000034616 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002)."Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin".Cell.108 (2):233–46.doi:10.1016/S0092-8674(01)00638-9.PMID 11832213.S2CID 5576208.
^^a ^b"Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".

Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007)."The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes".The Journal of Biological Chemistry.282 (44):32520–8.doi:10.1074/jbc.M707041200.PMC 2754063.PMID 17848544.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".Nature Biotechnology.24 (10):1285–92.doi:10.1038/nbt1240.PMID 16964243.S2CID 14294292.
Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005)."Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin".The EMBO Journal.24 (3):473–86.doi:10.1038/sj.emboj.7600543.PMC 548651.PMID 15660133.
Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin".Genes to Cells.8 (10):811–24.doi:10.1046/j.1365-2443.2003.00678.x.PMID 14531860.S2CID 24247372.

Esterase:protein tyrosine phosphatases (EC 3.1.3.48)

Class I

Classical PTPs

Receptor type PTPs	PTPRA PTPRB PTPRC PTPRD PTPRE PTPRF PTPRG PTPRH PTPRJ PTPRK PTPRM PTPRN PTPRN2 PTPRO PTPRQ PTPRR PTPRS PTPRT PTPRU PTPRZ1 PTPRZ2
Non receptor type PTPs	PTPN1 PTPN2 PTPN3 PTPN4 PTPN5 PTPN6 PTPN7 PTPN9 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN20 PTPN21 PTPN22 PTPN23

VH1-like or
dual specific
phosphatases
(DSPs)

MAPK phosphatases (MKPs)	DUSP1 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 DUSP10 DUSP16 MK-STYX
Slingshots	SSH1 SSH2 SSH3
PRLs	PTP4A1 PTP4A2 PTP4A3
CDC14s	CDC14A CDC14B CDKN3 PTP9Q22
Atypical DSPs	DUSP3 DUSP11 DUSP12 DUSP13A DUSP13B DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP22 DUSP23 DUSP24 DUSP25 DUSP26 DUSP27 EMP2A RNGTT STYX
Phosphatase and tensin homologs (PTENs)	PTEN TPIP TPTE TNS TENC1
Myotubularins	MTM1 MTMR2 MTMR3 MTMR4 MTMR5 MTMR6 MTMR7 MTMR8 MTMR9 MTMR10 MTMR11 MTMR12 MTMR13 MTMR14 MTMR15