Suppressor of cytokine signaling 2 is aprotein that in humans is encoded by theSOCS2gene.[5][6][7]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known assuppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, includingerythropoietin,GM-CSF,IL10 andinterferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain ofinsulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[8]Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[7][9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, et al. (October 1997). "Cloning and characterization of novel CIS family genes".Biochemical and Biophysical Research Communications.239 (2):439–446.doi:10.1006/bbrc.1997.7484.PMID9344848.
^Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, et al. (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3".Biochemical and Biophysical Research Communications.237 (1):79–83.doi:10.1006/bbrc.1997.7080.PMID9266833.
^Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J (December 2001). "Design and application of a cytokine-receptor-based interaction trap".Nature Cell Biology.3 (12):1114–1119.doi:10.1038/ncb1201-1114.PMID11781573.S2CID10228882.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation".Trends in Biochemical Sciences.27 (5):235–241.doi:10.1016/S0968-0004(02)02085-6.PMID12076535.
Pezet A, Buteau H, Kelly PA, Edery M (May 1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor".Molecular and Cellular Endocrinology.129 (2):199–208.doi:10.1016/S0303-7207(97)00063-4.PMID9202403.S2CID10606236.
Yandava CN, Pillari A, Drazen JM (October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively".Genomics.61 (1):108–111.doi:10.1006/geno.1999.5937.PMID10512686.
Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J (December 2001). "Design and application of a cytokine-receptor-based interaction trap".Nature Cell Biology.3 (12):1114–1119.doi:10.1038/ncb1201-1114.PMID11781573.S2CID10228882.
Biener E, Maurice S, Sandowski Y, Cohen Y, Gusakowsky EE, Hooghe R, et al. (July 2002). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization".Protein Expression and Purification.25 (2):305–312.doi:10.1016/S1046-5928(02)00013-X.PMID12135564.
