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SNF1LK2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

SIK2

Identifiers

Aliases

SIK2, LOH11CR1I, QIK, SNF1LK2, SIK-2, salt inducible kinase 2

External IDs

OMIM:608973;MGI:2445031;HomoloGene:22875;GeneCards:SIK2;OMA:SIK2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q23.1	Start	111,602,449bp^[1]
Band	11q23.1	End	111,730,855bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A5.3	Start	50,804,101bp^[2]
Band	9\|9 A5.3	End	50,920,373bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Epithelium of choroid plexus

cardia

germinal epithelium

adipose tissue

lower lobe of lung

hair follicle

subcutaneous adipose tissue

stromal cell of endometrium

Skeletal muscle tissue of biceps brachii

synovial joint

Top expressed in

brown adipose tissue

otic vesicle

white adipose tissue

mammary gland

subcutaneous adipose tissue

ascending aorta

muscle of thigh

neural layer of retina

genital tubercle

aortic valve

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding metal ion binding kinase activity
Cellular component	cytoplasm nucleus nucleotide-activated protein kinase complex
Biological process	protein autophosphorylation protein phosphorylation intracellular signal transduction phosphorylation regulation of insulin receptor signaling pathway cellular response to hormone stimulus negative regulation of TOR signaling cellular response to glucose starvation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


23235


235344

Ensembl


ENSG00000170145


ENSMUSG00000037112

UniProt


Q9H0K1


Q8CFH6

RefSeq (mRNA)


NM_015191


NM_178710

RefSeq (protein)


NP_056006


NP_848825 NP_001391943 NP_001391944

Location (UCSC)

Chr 11: 111.6 – 111.73 Mb

Chr 9: 50.8 – 50.92 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase SIK2 is anenzyme that in humans is encoded by theSIK2gene.^[5]^[6]

Interactions

[edit]

SNF1LK2 has been shown tointeract withCRTC2.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000170145 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000037112 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico".International Journal of Oncology.24 (5):1339–44.doi:10.3892/ijo.24.5.1339.PMID 15067358.
^"Entrez Gene: SNF1LK2 SNF1-like kinase 2".
^Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004)."The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector".Cell.119 (1):61–74.doi:10.1016/j.cell.2004.09.015.PMID 15454081.S2CID 18616459.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones".DNA Research.9 (3):99–106.CiteSeerX 10.1.1.500.923.doi:10.1093/dnares/9.3.99.PMID 12168954.
Bonaldo MF, Lennon G, Soares MB (Sep 1996)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Research.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998)."Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Research.5 (5):277–86.doi:10.1093/dnares/5.5.277.PMID 9872452.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001)."Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs".Genome Research.11 (3):422–35.doi:10.1101/gr.GR1547R.PMC 311072.PMID 11230166.
Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (May 2003)."Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2".The Journal of Biological Chemistry.278 (20):18440–7.doi:10.1074/jbc.M211770200.PMID 12624099.
Katoh M, Katoh M (Nov 2003). "Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats".International Journal of Oncology.23 (5):1471–6.doi:10.3892/ijo.23.5.1471.PMID 14532992.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (Feb 2004)."LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1".The EMBO Journal.23 (4):833–43.doi:10.1038/sj.emboj.7600110.PMC 381014.PMID 14976552.
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004)."The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector".Cell.119 (1):61–74.doi:10.1016/j.cell.2004.09.015.PMID 15454081.S2CID 18616459.
Katoh Y, Takemori H, Min L, Muraoka M, Doi J, Horike N, Okamoto M (Nov 2004)."Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm".European Journal of Biochemistry.271 (21):4307–19.doi:10.1111/j.1432-1033.2004.04372.x.PMID 15511237.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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