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SNF1LK2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SIK2
Identifiers
AliasesSIK2, LOH11CR1I, QIK, SNF1LK2, SIK-2, salt inducible kinase 2
External IDsOMIM:608973;MGI:2445031;HomoloGene:22875;GeneCards:SIK2;OMA:SIK2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SIK2
Genomic location for SIK2
Band11q23.1Start111,602,449bp[1]
End111,730,855bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for SIK2
Genomic location for SIK2
Band9|9 A5.3Start50,804,101bp[2]
End50,920,373bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Epithelium of choroid plexus

  • cardia

  • germinal epithelium

  • adipose tissue

  • lower lobe of lung

  • hair follicle

  • subcutaneous adipose tissue

  • stromal cell of endometrium

  • Skeletal muscle tissue of biceps brachii

  • synovial joint
Top expressed in
  • brown adipose tissue

  • otic vesicle

  • white adipose tissue

  • mammary gland

  • subcutaneous adipose tissue

  • ascending aorta

  • muscle of thigh

  • neural layer of retina

  • genital tubercle

  • aortic valve
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23235

235344

Ensembl

ENSG00000170145

ENSMUSG00000037112

UniProt

Q9H0K1

Q8CFH6

RefSeq (mRNA)

NM_015191

NM_178710

RefSeq (protein)

NP_056006

NP_848825
NP_001391943
NP_001391944

Location (UCSC)Chr 11: 111.6 – 111.73 MbChr 9: 50.8 – 50.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase SIK2 is anenzyme that in humans is encoded by theSIK2gene.[5][6]

Interactions

[edit]

SNF1LK2 has been shown tointeract withCRTC2.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000170145Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000037112Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Katoh M, Katoh M (May 2004). "Identification and characterization of human FOXN5 and rat Foxn5 genes in silico".International Journal of Oncology.24 (5):1339–44.doi:10.3892/ijo.24.5.1339.PMID 15067358.
  6. ^"Entrez Gene: SNF1LK2 SNF1-like kinase 2".
  7. ^Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004)."The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector".Cell.119 (1):61–74.doi:10.1016/j.cell.2004.09.015.PMID 15454081.S2CID 18616459.

Further reading

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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