SMC may refer to:

• IEEE Systems, Man, and Cybernetics Society
• Special Metals Corporation, an alloy manufacturer
• Supreme Muslim Council, former organization in Mandatory Palestine
• San Miguel Corporation, a Philippine conglomerate
• Samsung Medical Center, a hospital in South Korea
• Salmaniya Medical Complex, a hospital in Bahrain
• Shanghai Municipal Council, a government in Shanghai during late 19th to early 20th century
• SMC Corporation, a Japanese industrial automation company
• Social Marketing Company, a Bangladeshi non-profit organisation
• Suzuki Motor Corporation, a Japanese multinational corporation
• Swathanthra Malayalam Computing, a software collective in India
• Scottish Mountaineering Club
• Sufi Muslim Council, UK
• Singapore Mediation Centre
• Satyrs Motorcycle Club
• The Singing Machine Company, akaraoke equipment provider

• St. Michael's College, Iligan City, Philippines
• Santa Monica College, California, US
• Sargodha Medical College, Punjab, Pakistan
• Senior Military College, any of six US colleges that offer ROTC programs
• Southwestern Michigan College, US
• Spartanburg Methodist College, South Carolina, US
• Stanley Medical College, Chennai, India
• Stewart's Melville College, Edinburgh, Scotland
• Swiss Management Center, a university in Switzerland

• Science Media Centre, UK press office
• Space and Missile Systems Center, the research and development command of the United States Space Force
• Surat Municipal Corporation, Gujarat, India
• Supreme Military Council (Ghana), ruling Ghana from 1975–1979
• Modern Centre Party (Stranka modernega centra), a Slovenian political party

• Seattle Men's Chorus, Washington, US
• SMC Recordings, San Francisco, California, US

• Shaw Multicultural Channel, a cable television channel in Vancouver, British Columbia, Canada
• Southern Media Corporation, a Cantonese television network in Guangdong, China

• Secret Maryo Chronicles, a video game

• Seasonal malaria chemoprevention
• Sheet moulding compound or sheet moulding composite, a reinforced polyester material
• Small Magellanic Cloud, a galaxy near the Milky Way
• SMC protein (Structural Maintenance of Chromosomes)
• Supplementary motor cortex, a part of the sensorimotor cortex
• Smooth muscle cell, a cell of involuntary non-striated muscle
• Symmetric monoidal category, a mathematical structure involving serial and parallel composition

• Sound and music computing
• Apple SMC, a video codec
• Secure multi-party computation, a cryptography problem
• Sequential Monte Carlo method, a set of algorithms
• Self-modifying code, code which modifies itself at load or runtime
• Sliding mode control, in control theory
• SMC connector, used in radio-frequency circuits
• Surface-mount component, in electronics
• .smc, a file format used for Super Nintendo Entertainment System ROM images
• System Management Controller, on Apple computers
• DO-214AB, a variant ofDO-214 semiconductor package

• Semarang Poncol railway station, Semarang, Indonesia (station code: SMC)
• Serbia and Montenegro Cup
• Senior Mathematical Challenge, for students run by theUnited Kingdom Mathematics Trust
• Single-member constituency
• Speak Mandarin Campaign, Singapore
• Stade Malherbe Caen, a French football club

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